Publications by authors named "Caitlyn McLoughlin"
Opioid overdose deaths are an evolving public health emergency in the United States. Recent advancements in drug conjugate vaccine design and adjuvantation technologies have re-ignited interest in the potential clinical utility of opioid vaccination. Here we present the concept of fentanyl vaccination as a complementary strategy for opioid overdose prevention with a focus on vaccine safety, efficacy, and considerations for vaccine development and testing in early phase human clinical trials.
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- 2-Hydroxyethyl mercapturic acid (2HEMA) is a compound found in urine that signals exposure to certain harmful substances in cigarette smoke, including acrylonitrile and ethylene oxide.
- Researchers analyzed urine samples from over 7,400 participants to evaluate the relationship between smoking and 2HEMA levels, using factors like age, race, diet, and cigarettes smoked per day.
- The findings revealed that 85% of exclusive smokers had detectable 2HEMA, with higher smoking intensity correlating with increased levels; those smoking more than 19 cigarettes per day had 61% higher 2HEMA concentrations compared to lighter smokers.