The study focused on developing two questionnaires to assess the signs and symptoms of eosinophilic esophagitis (EoE) in children ages 1 to less than 12 years, taking into account that younger patients may struggle to self-report their symptoms.
Researchers conducted literature reviews, expert meetings, and interviews with children and their caregivers to identify relevant symptoms and ensure the questionnaires were understandable and comprehensive.
The result was the Pediatric Eosinophilic Esophagitis Sign/Symptom Questionnaire for self-reporting in older children (PESQ-P) and a caregiver-reported version (PESQ-C), which both showed strong content validity for use in clinical trials.