Publications by authors named "Caitlyn B Gries"
Front Med (Lausanne)
April 2023
Article Synopsis
- The research explores the use of a novel ferret tracheal injury and cell engraftment model to study airway biology, highlighting a gap in the use of such models compared to traditional animal models.
- The study introduces a whole-mount staining protocol that reveals detailed structural anatomy of the airway epithelium and submucosal glands, offering advantages over traditional 2D tissue sections.
- A novel 3D-printed culture chamber facilitates live imaging and cell differentiation at an air-liquid interface, aiming to improve cell-based therapies for pulmonary diseases.
Article Synopsis
- Keratin expression in airway basal cells changes after lung injury, affecting their behavior, but the specific impacts have not been fully understood.
- In a study related to bronchiolitis obliterans (an issue post-lung transplant), a shift from keratin15 (Krt15) to keratin14 (Krt14) was linked to reduced cell division ability (clonogenicity) in these cells.
- Using genetic techniques, the research found that Krt14 promotes more cell growth but hinders differentiation, while Krt15 supports differentiation but decreases growth, highlighting their distinct roles in cell behavior, especially in chronic diseases like bronchiolitis obliterans.
