Evaluation of preoperative intraperitoneal injection of bupivacaine for intraoperative antinociception in cats undergoing ovariohysterectomy: A randomized clinical trial.

Objective: To determine if preoperative intraperitoneal bupivacaine can minimize intra- and postoperative nociception/pain in cats undergoing ovariohysterectomy.

Study Design: Prospective, randomized, investigator-blinded, placebo-controlled clinical trial.

Animals: Forty-seven, intact female cats.

Ultrasound-guided ventral approach to the brachial plexus block in barred owls (Strix varia): a cadaveric study.

Objective: To develop an ultrasound (US)-guided ventral approach to the brachial plexus (BP) and evaluate nerve anatomy and staining in barred owl cadavers.

Study Design: Prospective, cadaveric study.

Animals: Eleven adult male and female barred owl cadavers with a body mass of 0.

Evaluation of preoperative rectus sheath block with bupivacaine for analgesia in cats undergoing ovariohysterectomy: a cadaveric and randomized clinical study.

Objective: Phase 1: to determine the feasibility of desensitizing ventral branches of spinal nerves within the rectus sheath using an ultrasound-guided rectus sheath block (USRSB). Phase 2: to determine the effect of preoperative USRSB on intraoperative responses to surgical stimulation and postoperative pain.

Study Design: Cadaveric study and prospective, randomized, blinded, parallel-arm clinical trial.

Ultrasound-guided sciatic nerve block injections in barred owl (Strix varia) cadavers.

Objective: To describe an ultrasound-guided approach to the sciatic nerve and the distribution of nerve staining using two injectate volumes of dye in barred owls.

Study Design: Descriptive, randomized, assessor-blinded, cadaveric study.

Animals: Twelve barred owl cadavers.

A case of epiglottic entrapment in a cat.

Objective: The objective of this study was to describe a case of epiglottic entrapment in a cat.

Case Summary: A 5-month-old male neutered Russian Blue cat was evaluated for progressive stertorous upper airway sounds, acute onset vestibulopathy and abnormal laryngeal anatomy. Endotracheal intubation was only able to be achieved using videoscopic guidance and identified concern for severe nasopharyngeal stenosis.

Effect of the reverse Trendelenburg position on the incidence of gastroesophageal reflux in dogs anesthetized for elective stifle surgery.

Objective: To determine if a 15° reverse Trendelenburg position decreases the incidence of gastroesophageal reflux (GER) compared with a horizontal position in dogs anesthetized for stifle surgery.

Study Design: Prospective, randomized parallel-arm study.

Animals: A total of 44 healthy client-owned dogs were enrolled and data from 36 dogs were analyzed.

Species Differences in Metabolism of Soluble Epoxide Hydrolase Inhibitor, EC1728, Highlight the Importance of Clinically Relevant Screening Mechanisms in Drug Development.

There are few novel therapeutic options available for companion animals, and medications rely heavily on repurposed drugs developed for other species. Considering the diversity of species and breeds in companion animal medicine, comprehensive PK exposures in the companion animal patient is often lacking. The purpose of this paper was to assess the pharmacokinetics after oral and intravenous dosing in domesticated animal species (dogs, cats, and horses) of a novel soluble epoxide hydrolase inhibitor, EC1728, being developed for the treatment of pain in animals.

Comparison between the effects of postanesthetic xylazine and dexmedetomidine on characteristics of recovery from sevoflurane anesthesia in horses.

Objective: To compare postanesthetic xylazine and dexmedetomidine on recovery characteristics from sevoflurane anesthesia in horses.

Study Design: Randomized, crossover study.

Animals: Six geldings, mean±standard deviation (SD) (range), 17±4 (11-24) years and 527±80 (420-660) kg.

Cardiovascular, respiratory and metabolic responses to apnea induced by atlanto-occipital intrathecal lidocaine injection in anesthetized horses.

Objective: To determine physiologic responses to apnea-induced severe hypoxemia in anesthetized horses.

Study Design: Prospective experimental study.

Animals: Six university-owned horses with a median (range) body weight of 500 (220-510) kg and aged 13.

Cardiovascular effects of equipotent doses of isoflurane alone and isoflurane plus fentanyl in New Zealand White rabbits (Oryctolagus cuniculus).

OBJECTIVE To determine effects of equipotent concentrations of fentanyl and isoflurane, compared with isoflurane alone, on cardiovascular variables in New Zealand White rabbits (Oryctolagus cuniculus). ANIMALS 6 adult female New Zealand White rabbits. PROCEDURES Rabbits were anesthetized with isoflurane, and lungs were mechanically ventilated.

Evaluation of trends in marijuana toxicosis in dogs living in a state with legalized medical marijuana: 125 dogs (2005-2010).

Objective: To report a correlation between the increased number of medical marijuana licenses and marijuana toxicosis in dogs in a state with legalized marijuana for medical use.

Design: Retrospective case series from January 1, 2005 to October 1, 2010.

Setting: Private specialty referral hospital and a university teaching hospital.

Ultrasound-guided transversus abdominis plane block in the dog: an anatomical evaluation.

Objective: To describe the ultrasound-guided technique to the transversus abdominis plane (TAP) block in the dog and evaluate the spread of a local anesthetic/methylene blue solution.

Study Design: Prospective experimental trial.

Animals: Ten adult Beagle cadavers weighing 11.