Publications by authors named "Caitlin Sannes"
Article Synopsis
- T cells are crucial in the development of systemic lupus erythematosus (SLE), and chronic signaling can lead to T cell exhaustion, reducing their tissue damage capacity.
- Researchers tested an anti-TCRβ monoclonal antibody (mAb) in SLE mouse models, finding that it significantly increased survival rates and reduced kidney damage compared to controls.
- The treatment also altered T cell profiles, increasing regulatory T cells and inducing an exhaustion-like state in CD4 T cells, suggesting that promoting T cell exhaustion could be a beneficial therapeutic strategy for SLE.
Persistent hypoxia in bone metastases induces an immunosuppressive environment, limiting the effectiveness of immunotherapies. To address chronic hypoxia, we have developed manganese dioxide (MnO) nanoparticles with tunable oxygen production kinetics for sustained oxygenation in bone metastases lesions. Using polyethylene glycol (PEG)-stabilized MnO or poly(lactic[50]--glycolic[50] acid) (50:50 PLGA), poly(lactic[75]--glycolic[25] acid) (75:25 PLGA), and polylactic acid (PLA)-encapsulated MnO NPs, we demonstrate that polymer hydrophobicity attenuates burst oxygen production and enables tunable oxygen production kinetics.
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