Publications by authors named "Caitlin S Croft"
Many occupational therapists make home modification recommendations; however, it is unknown if sustainability considerations (i.e., economic, social, and environmental) are contemplated during this process.
View Article and Find Full Text PDFEpigenetic regulation of gene expression is in part controlled by post-translational modifications on histone proteins. Histone methylation is a key epigenetic mark that controls gene transcription and repression. There are five human polycomb paralog proteins (Cbx2/4/6/7/8) that use their chromodomains to recognize trimethylated lysine 27 on histone 3 (H3K27me3).
View Article and Find Full Text PDFArticle Synopsis
- The polycomb paralogs CBX2, CBX4, CBX6, CBX7, and CBX8 are crucial epigenetic readers that interact with methyllysine side chains using similar chromodomains, but each has unique functions.
- CBX7 is notable for being the only chromodomain without a chemical inhibition method available, prompting a study on peptidomimetics that can selectively inhibit other paralogs.
- The research revealed a set of agents that, through slight chemical modification, can switch from affecting multiple polycomb proteins to specifically inhibiting CBX6, confirmed by molecular dynamics simulations showing enhanced binding affinity due to engagement of the chromodomain's extended binding surface.