Publications by authors named "Caitlin E Ross"
Article Synopsis
- - Kisspeptin plays a crucial role in regulating gonadotropin secretion in pigs, and a study was conducted on F1 pigs from a parental line created by CRISPR/Cas9 knockout of the KISS1 gene, which eliminates the need for castration.
- - The research measured body weights, gonadotropin levels, and reproductive development in these pigs, finding that while body weight didn't differ based on genotype, KISS1-/- boars and gilts exhibited significantly reduced gonadotropin concentrations and experienced hypogonadism.
- - The results suggest that only one functional KISS1 allele is necessary for normal gonadal function and hormone secretion, and that the knockout of KISS1 does
The pig represents the only livestock mammal capable of producing a functional protein for the second mammalian form of gonadotropin-releasing hormone (GnRH-II) and its receptor (GnRHR-II). To examine the role of GnRH-II and its receptor in pig reproduction, we produced a unique swine line with ubiquitous knockdown of endogenous GnRHR-II levels (GnRHR-II knockdown [KD]), which is largely the focus of this review. In mature GnRHR-II KD males, circulating testosterone concentrations were 82% lower than littermate control boars, despite similar luteinizing hormone (LH) levels.
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