Fucoxanthin Induces Ferroptosis in Cancer Cells via Downregulation of the Nrf2/HO-1/GPX4 Pathway.

This study investigated the mechanism by which fucoxanthin acts as a novel ferroptosis inducer to inhibit tongue cancer. The MTT assay was used to detect the inhibitory effects of fucoxanthin on SCC-25 human tongue squamous carcinoma cells. The levels of reactive oxygen species (ROS), mitochondrial membrane potential (MMP), glutathione (GSH), superoxide dismutase (SOD), malondialdehyde (MDA), and total iron were measured.

Anti-Leukemia Activity of Polysaccharide from via the PI3K/AKT/BAD Pathway In Vivo and In Vitro.

Studies have shown that and its extracts are effective herbal treatments for leukemia. We previously found that a polysaccharide from , SFP 2205, stimulated apoptosis in human erythroleukemia (HEL) cells. However, the structural characterization and antitumoral mechanisms of SFP 2205 remain uncertain.

Protein from protects MRC-5 cells against hydrogen peroxide (HO)-induced damage.

The cytoprotective and potential molecular mechanisms of protein (RFPP) were investigated on the hydrogen peroxide (HO)-triggered damage in normal human embryonic lung (MRC-5) cells. An MTT assay was conducted to assess the MRC-5 cell viability after exposure to HO or RFPP. Cell cycle distribution and apoptosis were explored via flow cytometry.

Allergic rhinitis, allergic contact dermatitis and disease comorbidity belong to separate entities with distinct composition of T-cell subsets, cytokines, immunoglobulins and autoantibodies.

Background: Allergic rhinitis (AR) and allergic contact dermatitis (ACD) are prevalent allergic diseases and have significant impacts on patients' daily life. Despite many studies on AR or ACD have been conducted separately, little is known about the immune responses in patients of AR combined with ACD and the interplay between AR and ACD. Our study compared various aspects of immune elements in patients with AR or/and ACD, aiming to characterize the immune responses in AR, ACD, and AR combined with ACD.

Transcriptomic profile of human erythroleukemia cells in response to Sargassum fusiforme polysaccharide and its structure analysis.

Sargassum fusiforme (S. fusiforme) has been used as an ingredient in Chinese herbal medicine for thousands of years. However, there are a limited number of studies concerning its therapeutic mechanism.

Effect of Sargassum fusiforme polysaccharide on apoptosis and its possible mechanism in human erythroleukemia cells.

This study aimed to investigate the effects of Sargassum fusiforme polysaccharide (SFPS I, II, and III) on the apoptosis and regulation of human erythroleukemia (HEL) cells. The effect of different doses of SFPS on HEL cell growth was detected using the Cell Counting Kit-8 method, and apoptosis was detected by Hoechst staining. Cell cycle distribution and apoptosis were detected using flow cytometry.

Electrospun ZnO-SnO Composite Nanofibers and Enhanced Sensing Properties to SF Decomposition Byproduct HS.

Hydrogen sulfide (HS) is an important decomposition component of sulfur hexafluoride (SF), which has been extensively used in gas-insulated switchgear (GIS) power equipment as insulating and arc-quenching medium. In this work, electrospun ZnO-SnO composite nanofibers as a promising sensing material for SF decomposition component HS were proposed and prepared. The crystal structure and morphology of the electrospun ZnO-SnO samples were investigated by X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM), respectively.

EFFECT OF FUCOIDAN ON B16 MURINE MELANOMA CELL MELANIN FORMATION AND APOPTOSIS.

Background: Fucoidan is a complex sulfated polysaccharide extracted from brown seaweed and has a wide variety of biological activities. It not only inhibits cancer cell growth but also inhibits tyrosinase in vitro. Therefore, it is of interest to investigate the effect of fucoidan on B16 murine melanoma cells as the findings may provide new insights into the underlying mechanism regarding the inhibition of melanin formation by fucoidan.

Genotypes of the Hepatitis C Virus in Infected Patients in Hohhot, China.

We wished to identify the existing HCV genotypes in diagnosed cases of infection by the hepatitis C virus in Hohhot (China) to offer basic data for the treatment and prevention of HCV infection in this area. Outpatients and inpatients were recruited from hospitals in Hohhot from January 2014 to January 2015. In total, 149 patients with HCV infection confirmed by positive anti-HCV and HCV-RNA tests were selected.

Establishment and characterization of a cell line from the Chinese soft-shelled turtle Pelodiscus sinensis.

The establishment and partial characterization of Pelodiscus sinensis continuous cell line is described here. A novel P. sinensis fibroblast cell line, designated PSF, was established from heart tissue by the semi-digestion explant culture technique.

Effects of Sargassum fusiforme polysaccharides on antioxidant activities and intestinal functions in mice.

Sargassum fusiforme is a kind of brown algae that has been widely consumed not only as food, but also as herbal medicine for thousands of years. The purpose of this study was to investigate the antioxidant activities and intestinal functions of polysaccharides extracted from S. fusiforme (SFP) in normal and cyclophosphamide-induced immunosuppressed mice.

[Study on the application of benchmark dose and biological monitoring indexes of fluorides in drinking water].

Objective: By using Benchmark Dose (BMD) approach to explore the relations among drinking water fluoride, urine fluoride, serum fluoride and dental fluorosis; and to evaluate the significance of urine fluoride and serum fluoride in control and prevention of endemic fluorosis.

Methods: 512 children (290 in Xinhuai Village, 222 in Wamiao Village) aged 8-13 years were recruited in the study. Epidemiological methods were used to investigate the prevalence of dental fluorosis, and the levels of urine fluoride, serum fluoride, and drinking water fluoride in superficial well.