Influence of circadian rhythm on effects induced by mechanical strain in periodontal ligament cells.

Purpose: The aim of this study was to investigate the influence of mechanical strain on clock gene function in periodontal ligament (PDL) cells. Furthermore, we wanted to analyze whether effects induced by mechanical stress vary in relation to the circadian rhythm.

Methods: Human PDL fibroblasts were synchronized in their circadian rhythm with dexamethasone and stretched over 24 h.