Publications by authors named "Caio Cesar de Lima Silva"
Inhibition of L-Threonine Dehydrogenase from Trypanosoma cruzi reduces glycine and acetate production and interferes with parasite growth and viability.
J Biol Chem
December 2024
Article Synopsis
- Trypanosoma cruzi is the protozoan responsible for Chagas Disease, which lacks effective diagnostic and treatment options, prompting a study of its metabolism and adaptation to different environments.
- Recent research shows T. cruzi can utilize various carbon sources, including threonine, during growth and starvation, leading to the discovery of a pathway for threonine degradation.
- The study identified a compound (TCMDC-143160) that inhibits a key enzyme (TcTDH) involved in threonine catabolism, providing insights into potential therapeutic targets for Chagas Disease.
Salicylic acid (SA) and its methyl ester, methyl salicylate (MeSA) are well known inducers of local and systemic plant defense responses, respectively. MeSA is a major mediator of systemic acquired resistance (SAR) and its conversion back into SA is thought to be required for SAR. In many plant species, conversion of MeSA into SA is mediated by MeSA esterases of the SABP2 family.
View Article and Find Full Text PDFMitogen-activated protein kinases (MAPK) play crucial roles in plant immunity. We previously identified a citrus MAPK (CsMAPK1) as a differentially expressed protein in response to infection by Xanthomonas aurantifolii, a bacterium that causes citrus canker in Mexican lime but a hypersensitive reaction in sweet oranges. Here, we confirm that, in sweet orange, CsMAPK1 is rapidly and preferentially induced by X.
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