Strong electronic interaction enhanced electrocatalysis of copper phthalocyanine decorated Co-MOF-74 toward highly efficient oxygen evolution reaction.

Metal-organic frameworks (MOFs) have been identified as promising electrocatalysts for the oxygen evolution reaction (OER). However, most of the reported MOFs have low electrical conductivity and poor stability, and therefore addressing these problems is crucial for achieving higher electrocatalytic performance. Meanwhile, direct observations of the electrocatalytic behavior, which is of great significance to the understanding of the electrocatalytic mechanism, remain highly challenging.

Alterations in maternal-fetal gut and amniotic fluid microbiota associated with fetal growth restriction.

Background: Fetal growth restriction (FGR) is typically characterised as the fetus' inability to reach its inherent growth potential. A growing body of evidence points to the important role of the maternal gut microbiota in FGR development. However, comprehensive research on changes in maternal-fetal gut and intrauterine microbiota related to FGR is lacking.

Unconventional hcp/fcc Nickel Heteronanocrystal with Asymmetric Convex Sites Boosts Hydrogen Oxidation.

Developing non-platinum group metal catalysts for the sluggish hydrogen oxidation reaction (HOR) is critical for alkaline fuel cells. To date, Ni-based materials are the most promising candidates but still suffer from insufficient performance. Herein, we report an unconventional hcp/fcc Ni (u-hcp/fcc Ni) heteronanocrystal with multiple epitaxial hcp/fcc heterointerfaces and coherent twin boundaries, generating rugged surfaces with plenty of asymmetric convex sites.

Ru-Doped NiFe-MIL-53 with Facilitated Reconstruction and Active Hydrogen Supplement for Enhanced Nitrate Reduction.

The Electrochemical reduction of nitrate to ammonia (NH) is a process of great significance to energy utilization and environmental protection. However, it suffers from sluggish multielectron/proton-involved steps involving coupling reactions between different reaction intermediates and active hydrogen species (H) produced by water decomposition. In this study, a Ru-doped NiFe-MIL-53 (NiFeRu-MIL-53) supported on Ni foam (NF) has been designed for the nitrate reduction reaction (NORR).

CircTHBS1 promotes trophoblast cell migration and invasion and inhibits trophoblast apoptosis by regulating miR-136-3p/IGF2R axis.

The precise molecular mechanism behind fetal growth restriction (FGR) is still unclear, although there is a strong connection between placental dysfunction, inadequate trophoblast invasion, and its etiology and pathogenesis. As a new type of non-coding RNA, circRNA has been shown to play a crucial role in the development of FGR. This investigation identified the downregulation of hsa_circ_0034533 (circTHBS1) in FGR placentas through high-sequencing analysis and confirmed this finding in 25 clinical placenta samples using qRT-PCR.

CO-Tolerant Hydrogen Oxidation Electrocatalysts for Low-Temperature Hydrogen Fuel Cells.

The severe performance degradation of low-temperature hydrogen fuel cells upon exposure to trace amounts of carbon monoxide (CO) impurities in reformate hydrogen fuels is one of the challenges that hinders their commercialization. Despite significant efforts that have been made, the CO-tolerance performance of electrocatalysts for the hydrogen oxidation reaction (HOR) is still unsatisfactory. This Perspective discusses the path forward for the rational design of CO-tolerant HOR electrocatalysts.

A large deletion in TSC2 causes tuberous sclerosis complex by dysregulating PI3K/AKT/mTOR signaling pathway.

Background/aim: Tuberous sclerosis complex (TSC) is a multi-system syndrome caused by loss-of-function mutation in TSC1 or TSC2. Most TSC patients present with cardiac rhabdomyoma or cortical tubers during fetal life, and the symptoms are not uniform as their age. The gene products of TSC1/2 are components of the TSC protein complex and are important role in the PI3K/AKT/mTOR (PAM) signaling pathway.

Ru-Doped Ultrasmall Cu Nanoparticles Decorated with Carbon for Electroreduction of Nitrate to Ammonia.

Electrocatalytic nitrate reduction reaction offers a sustainable approach to treating wastewater and synthesizing high-value ammonia under ambient conditions. However, electrocatalysts with low faradaic efficiency and selectivity severely hinder the development of nitrate-to-ammonia conversion. Herein, Ru-doped ultrasmall copper nanoparticles loaded on a carbon substrate (Cu-Ru@C) were fabricated by the pyrolysis of Cu-BTC metal-organic frameworks (MOFs).

Structure and Defect Engineering Synergistically Boost High Solar-to-Chemical Conversion Efficiency of Cerium oxide/Au Hollow Nanomushrooms for Nitrogen Photofixation.

Photocatalytic nitrogen fixation using solar illumination under ambient conditions is a promising strategy for production of the indispensable chemical NH . However, due to the catalyst's limitations in solar energy utilization, loss of hot electrons during transfer, and low nitrogen adsorption and activation capacity, the unsatisfactory solar-to-chemical conversion (SCC) efficiencies of most photocatalysts limit their practical applications. Herein, cerium oxide nanosheets with abundant strain-V defects were anchored on Au hollow nanomushroom through atomically sharp interfaces to construct a novel semiconductor/plasmonic metal hollow nanomushroom-like heterostructure (denoted cerium oxide-AD/Au).

Powerful Orbital Hybridization of Copper-Silver Bimetallic Nanosheets for Electrocatalytic Nitrogen Reduction to Ammonia.

Electrochemical nitrogen reduction (eNRR) is a promising strategy to replace the energy- and capital-intensive Haber-Bosch process. Unfortunately, the low selectivity of the eNRR process impedes the industrial application of this approach. In this work, a highly efficient and stable NRR electrocatalyst is obtained via coreduction of Cu and Ag precursors using the holly leaves as reducing agents.

Selenite-Decorated Polycrystalline NiO Nanosheets Generated from Cathodic Reconstruction for Electrocatalytic Hydrogen Production.

Precatalyst reconstruction in alkaline hydrogen evolution reaction (HER) usually leads to changes in the morphology, composition, and structure, thus improving the catalytic activity, which recently receives intensive attention. However, the design strategies of cathodic reconstruction and the structural features of reconstruction products have not achieved a profound understanding. Here, from the point of thermodynamic stability, metastable nickel selenite dihydrate (NiSeO·2HO) is deliberately fabricated as a precatalyst to comprehensively study the reconstruction dynamics in alkaline HER.

Increased Oxygen Vacancies in CeO for Improved Electrocatalytic Nitrogen Reduction Performance.

Electrochemical nitrogen fixation is a sustainable and economical strategy to produce ammonia. However, fabricating efficient electrocatalysts for nitrogen fixation is still challenging. Theoretical predictions prove that the oxygen vacancy is able to modulate the electronic state of CeO and enhance its electrical conductivity, thus promoting the electrochemical nitrogen reduction reaction (NRR) process.

Performance of whole-genome promoter nucleosome profiling of maternal plasma cell-free DNA for prenatal noninvasive prediction of fetal macrosomia: a retrospective nested case-control study in mainland China.

Background: Fetal macrosomia is common occurrence in pregnancy, which is associated with several adverse prognosis both of maternal and neonatal. While, the accuracy of prediction of fetal macrosomia is poor. The aim of this study was to develop a reliable noninvasive prediction classifier of fetal macrosomia.

A Novel Mutation in ATRX Causes Alpha-Thalassemia X-Linked Intellectual Disability Syndrome in a Han Chinese Family.

Objective: To analyze genetic mutations in a Chinese pedigree affected with Alpha-thalassemia X-linked intellectual disability syndrome, providing a precise diagnosis and genetic counseling.

Methods: Clinical data was collected. A novel alternative splicing variant detected by whole-exome sequencing was validated by Sanger sequencing.

MOF-Derived CuP nanoparticles coated with N-doped carbon for nitrogen fixation.

Electrochemical nitrogen reduction is a significant alternative route for synthesizing ammonia, but constructing efficient catalysts for electrochemical nitrogen fixation still faces tough challenges. In this work, CuP@NC (NC: nitrogen-doped carbon) nanosheets were prepared the low-temperature pyrolysis-phosphating of Cu-MOFs. When applied to the nitrogen reduction reaction, CuP@NC exhibited a high ammonia yield rate of 10.

Transcriptomic Analysis Reveals Competitive Growth Advantage of Non-pigmented Mutants.

is a common bacterium well-known for the red secondary metabolite prodigiosin. However, color mutants have long been described. Non-pigmented strains can be found to exist both naturally and under laboratory conditions.

Amorphous ReS decorated TiO nanowire arrays for highly-efficient nitrogen reduction.

Herein, we constructed amorphous ReS nanosheets anchored on TiO nanowires by delicately forming Ti-O-Re bonds, which exhibited considerable average ammonia yield and faradaic efficiency as high as 5.3 μg h cm. and 49.

Complete Genome Sequence of the Red-Pigmented Strain Serratia marcescens SCQ1 and Its Four Spontaneous Pigment Mutants.

SCQ1 is a red-pigmented bacterium isolated from silkworm larva with septicemia. Pigment-deficient spontaneous mutants arise when SCQ1 is incubated under relatively stable laboratory conditions for a long time. Here, we present the complete genome sequence of SCQ1 and the resequenced genomes of four spontaneous pigment mutants.

In vitro transcriptomes analysis identifies some special genes involved in pathogenicity difference of the Beauveria bassiana against different insect hosts.

Typical entomopathogenic filamentous fungi such as Beauveria bassiana infect susceptible hosts via penetration of insect cuticle. The pathogenicity of B. bassiana strain to diverse insect hosts is different.

Bonding interface boosts the intrinsic activity and durability of NiSe@FeO heterogeneous electrocatalyst for water oxidation.

The intrinsic activity and durability of oxygen evolution reaction (OER) electrocatalysts are mainly dominated by the surface and interface properties of active materials. Herein, a core-shell heterogeneous structure (NF/NiSe@FeO) is fabricated via two-step hydrothermal method, which exhibits a low overpotential of 220 mV (or 282 mV) at 10 mA/cm (or 200 mA/cm), a small Tafel slope of 36.9 mV/dec, and long-term stability (~230 h) in 1 mol/L KOH for OER.

Whole-Genome Promoter Profiling of Plasma DNA Exhibits Diagnostic Value for Placenta-Origin Pregnancy Complications.

Placenta-origin pregnancy complications, including preeclampsia (PE), gestational diabetes mellitus (GDM), fetal growth restriction (FGR), and macrosomia (MA) are common occurrences in pregnancy, resulting in significant morbidity and mortality for both mother and fetus. However, despite their frequency, there are no reliable methods for the early diagnosis of these complications. Since cfDNA is mainly derived from placental trophoblasts and maternal hematopoietic cells, it might have information for gene expression which can be used for disease prediction.

Engineering the valence state of ZIF-67 by CuO for efficient nonenzymatic glucose detection.

The valence state regulation of Co-based electrocatalysts is extremely important and greatly challenging to enhance the electrochemical performance toward glucose oxidation. Herein, Cu2O@ZIF-67 composites with fine-tuned valence states were rationally constructed for boosting glucose oxidation. X-ray photoelectron spectroscopy (XPS) and cyclic voltammetry (CV) analysis confirm that the content of the high valence state Co (Co3+) in Cu2O@ZIF-67 is much higher than that in the individual ZIF-67 due to the synergistic effects between ZIF-67 and Cu2O.