Publications by authors named "Cailing Wan"
Article Synopsis
- The study investigates the mechanisms of resistance to ceftazidime-avibactam (CZA) in a hypervirulent strain of Klebsiella pneumoniae known as CRE146, which carries the bla gene.
- Researchers isolated twelve carbapenem-resistant Klebsiella pneumoniae strains from a single patient, employing whole genome sequencing and various pathogenicity tests to understand the virulence factors and resistance development.
- Findings revealed that the resistance was linked to drug exposure and involved specific genetic mutations in carbapenemase (KPC-228), with CRE146 showing high resistance to CZA while being more susceptible to other antibiotics like meropenem and imipenem.
() is an opportunistic pathogen that could cause life-threatening bloodstream infections. The objective of this study was to identify potential diagnostic biomarkers of bloodstream infection. Gene expression dataset GSE33341 was optimized as the discovery dataset, which contained samples from human and mice.
View Article and Find Full Text PDFThe ability to form robust biofilms and secrete a diverse array of virulence factors are key pathogenic determinants of , causing a wide range of infectious diseases. Here, we characterized as a VraR-regulated gene encoding a cell wall inhibition-responsive protein (CwrA) using electrophoretic mobility shift assays. We constructed deletion mutants in the genetic background of methicillin-resistant (MRSA) and methicillin-sensitive (MSSA) strains.
View Article and Find Full Text PDFUnlabelled: The widespread prevalence and dissemination of antibiotic-resistant bacteria, coupled with the diminishing supply of new antibiotics, emphasize the pressing necessity for the exploration of innovative antibacterial agents. Previously, we detailed the impact of the small-molecule compound CY-158-11 on biofilm. By hindering adhesion and PIA-mediated biofilm formation, subinhibitory concentrations of CY-158-11 exhibit antibiofilm activity toward .
View Article and Find Full Text PDFMethicillin-resistant (MRSA) sequence type 630 (ST630) is a rarely reported lineage worldwide. This study aimed to trace the dissemination of the emerging MRSA ST630 clones in China and investigate their virulence potential. We collected 22 ST630-MRSA isolates from across China and performed whole-genome sequencing analysis and virulence characterization on these isolates.
View Article and Find Full Text PDFBackground: Carbapenem-resistant (CRKP) infections are a great threat to public health worldwide. Ceftazidime-avibactam (CZA) is an effective -lactam/-lactamase inhibitors against CRKP. However, reports of resistance to CZA, mainly caused by carbapenemase (KPC) variants, have increased in recent years.
View Article and Find Full Text PDFArticle Synopsis
- A new compound called YH7 was developed, showing strong antimicrobial effects against both methicillin-resistant (MRSA) and methicillin-susceptible (MSSA) staphylococci, with a minimum inhibitory concentration (MIC) of 16 µg/mL.
- YH7 effectively inhibits biofilm formation and bacterial adherence, as evidenced by lab tests, and it also demonstrated a reduction in bacterial colonization in mouse nasal tissue.
- The compound works by disrupting the synthesis of a key component necessary for biofilms, proving to be biocompatible and unlikely to cause drug resistance, making it a promising candidate for treating persistent biofilm-related infections.