Topical application of a BCL-2 inhibitor ameliorates imiquimod-induced psoriasiform dermatitis by eliminating senescent cells.

Background: Psoriasis is an inflammatory skin disease with unclear pathogenesis and unmet therapeutic needs.

Objective: To investigate the role of senescent CD4 T cells in psoriatic lesion formation and explore the application of senolytics in treating psoriasis.

Methods: We explored the expression levels of p16 and p21, classical markers of cellular senescence, in CD4 T cells from human psoriatic lesions and imiquimod (IMQ)-induced psoriatic lesions.

Immune repertoire analysis of normal Chinese donors at different ages.

Objectives: This study investigated the characteristics of the immune repertoire in normal Chinese individuals of different ages.

Materials And Methods: In this study, all seven receptor chains from both B and T cells in peripheral blood of 16 normal Chinese individuals from two age groups were analyzed using high-throughput sequencing and dimer-avoided multiplex PCR amplification. Normal in this study is defined as no chronic, infectious or autoimmune disease within 6 months prior to blood draw.

Rational design of a cobalt sulfide nanoparticle-embedded flexible carbon nanofiber membrane electrocatalyst for advanced lithium-sulfur batteries.

Both the sluggish redox kinetics and severe polysulfide shuttling behavior hinders the commercialization of lithium-sulfur (Li-S) battery. To solve these obstacles, we design a cobalt sulfide nanoparticle-embedded flexible carbon nanofiber membrane (denoted as CoS@NCF) as sulfiphilic functional interlayer materials. The hierarchically porous structure of carbon nanofiber is conducive to immobilizing sulfur species and facilitating lithium-ion penetration.

Prussian blue analogs derived Fe-Ni-P@nitrogen-doped carbon composites as sulfur host for high-performance lithium-sulfur batteries.

Lithium-sulfur (Li-S) batteries have drawn a lot of attention owing to the high theoretical capacity of 1675 mAh g, environmental friendliness and relative abundance of sulfur. Nevertheless, the severe dissolution and migration of lithium polysulfides (LiPSs) and poor conductivity of sulfur greatly hinder the practical application of Li-S batteries. In this work, Fe-Ni-P@nitrogen-doped carbon (named as Fe-Ni-P@NC) derived from Fe-Ni Prussian blue analog (Fe-Ni PBA) was used as highly efficient sulfur host for Li-S batteries.

Development of an Enzyme-Linked Immunosorbent Assay Based on Fusion VP2332-452 Antigen for Detecting Antibodies against Aleutian Mink Disease Virus.

For detection of Aleutian mink disease virus (AMDV) antibodies, an enzyme-linked immunosorbent assay (ELISA) was developed using the recombinant VP2332-452 protein as an antigen. Counterimmunoelectrophoresis (CIEP) was used as a reference test to compare the results of the ELISA and Western blotting (WB); the specificity and sensitivity of the VP2332-452 ELISA were 97.9% and 97.