Publications by authors named "Cailin T Collins"
Article Synopsis
- Research on genetic mutations in human cancers seeks to understand their role in initiating and maintaining cancer, specifically focusing on acute myeloid leukemia (AML).
- In this study, CRISPR methods were used to correct mutations in AML cells from patients, revealing that while mutations are crucial for starting the disease, they are not needed for its ongoing maintenance.
- These findings suggest that the roles of initiating oncogenes differ significantly from those that sustain cancer, which could influence future cancer treatments and our understanding of cancer progression.
Purpose Of Review: HOXA9 is a homeodomain transcription factor that plays an essential role in normal hematopoiesis and acute leukemia, in which its overexpression is strongly correlated with poor prognosis. The present review highlights recent advances in the understanding of genetic alterations leading to deregulation of HOXA9 and the downstream mechanisms of HOXA9-mediated transformation.
Recent Findings: A variety of genetic alterations including MLL translocations, NUP98-fusions, NPM1 mutations, CDX deregulation, and MOZ-fusions lead to high-level HOXA9 expression in acute leukemias.