Dissemination of Driven by Horizontal Transfer of IncFIA Plasmid Between and Co-Isolated from a Patient's Ascitic Fluid.

Purpose: Understanding the horizontal transfer of resistance genes, such as , is pivotal in developing strategies to control the spread of resistance. In this study, we isolated two bacterial strains, (designated GYB01) and (designated GYB02), from a single patient. The aim of our research is to explore the biological characteristics of these strains and to investigate the interspecies horizontal transfer of .

Characterization of linezolid- and methicillin-resistant coagulase-negative staphylococci in a tertiary hospital in China.

Background: Recently, linezolid-resistant staphylococci have become an emerging problem worldwide. Understanding the mechanisms of resistance, molecular epidemiology and transmission of linezolid-resistant CoNS in hospitals is very important.

Methods: The antimicrobial susceptibilities of all isolates were determined by the microdilution method.

Difference analysis and characteristics of incompatibility group plasmid replicons in gram-negative bacteria with different antimicrobial phenotypes in Henan, China.

Background: Multi-drug-resistant organisms (MDROs) in gram-negative bacteria have caused a global epidemic, especially the bacterial resistance to carbapenem agents. Plasmid is the common vehicle for carrying antimicrobial resistance genes (ARGs), and the transmission of plasmids is also one of the important reasons for the emergence of MDROs. Different incompatibility group plasmid replicons are highly correlated with the acquisition, dissemination, and evolution of resistance genes.

Trends in antimicrobial resistance in bloodstream infections at a large tertiary-care hospital in China: a 10-year retrospective study (2010-2019).

Objectives: Bloodstream infections (BSIs) are a major cause of morbidity and mortality worldwide. This study aimed to explore the distribution and antimicrobial resistance of BSI pathogens at a tertiary-care hospital in China.

Methods: Surveillance blood cultures were routinely taken from patients with fever or suspected sepsis from 2010-2019 at the First Affiliated Hospital of Zhengzhou University.

The emergence of Staphylococcus epidermidis simultaneously nonsusceptible to linezolid and teicoplanin in China.

Two linezolid-resistant and teicoplanin-intermediate Staphylococcus epidermidis strains were isolated from blood cultures in China. The 2 S. epidermidis strains were methicillin-resistant and showed multidrug-resistance patterns; in addition, population analysis profiling/area under the curve (PAP/AUC) result showed heterogeneous resistant to vancomycin.

Increase in Candidemia in Cancer Patients.

This study aimed to identify the risk factors of candidemia and asses possible clinically significant differences between and other in a Chinese tertiary cancer center over six years. A total of 323 cancer patients were enrolled and analyzed from 2012 to 2018. Among the isolates, the species most frequently isolated was (37.

Nanoparticles Patterned Ceramsites Showing Super-Hydrophobicity and Low Crushing Rate: The Promising Proppant for Gas and Oil Well Fracturing.

An ideal proppant showing super-hydrophobicity and enough strength to bear high closure stress is revolutionary for the effective exploration of gas or oil in shale. Here, the ideal proppants were obtained by wrapping specially treated phenol formaldehyde resins around the cover of the traditional ceramsites. The resin coating is patterned with innumerable fluorine-modified silica nanoparticles, whose thickness is controllable.

Mechanism for carbapenem resistance of clinical Enterobacteriaceae isolates.

Carbapenemase-producing 'super bacteria', particularly NDM-1 and its variants, have become a major public health concern worldwide. The present study aimed to explore the molecular mechanism for carbapenem resistance of clinical Enterobacteriaceae isolates. Seventy-eight non-repeated Enterobacteriaceae strains resistant to any carbapenem were screened at the First Affiliated Hospital of Zhengzhou University (Zhengzhou, China) between December 2011 and December 2015.

Characterization of Teicoplanin Nonsusceptible Staphylococcus epidermidis Clinical Isolates Belonging Predominantly to ST267.

Staphylococcus epidermidis is the main cause of bacteremia and infections of indwelling catheters, glycopeptide antibiotics are often considered as the choice of empirical drugs for the treatment of staphylococcal infections. In the present study, 12 teicoplanin nonsusceptible S. epidermidis isolates were collected between January and October 2013.

Molecular correlates and prognostic value of tmTNF-α expression in colorectal cancer of 5-Fluorouracil-Based Adjuvant Therapy.

Transmembrane tumor necrosis factor-α (tmTNF-α) is known to induce the activation of NF-κB to protect tumor cells. Upregulation of tmTNF-α leads to resistance to apoptosis and induces drug resistance in breast cancer. However, the expression of tmTNF-α in colorectal cancer (CRC) and its association with clinical outcome in CRC have remained unclear.

New Delhi Metallo-β-Lactamase 1(NDM-1), the Dominant Carbapenemase Detected in Carbapenem-Resistant Enterobacter cloacae from Henan Province, China.

The emergence of New Delhi metallo-β-lactamase 1 (NDM-1) has become established as a major public health threat and represents a new challenge in the treatment of infectious diseases. In this study, we report a high incidence and endemic spread of NDM-1-producing carbapenem-resistant Enterobacter cloacae isolates in Henan province, China. Eight (72.

Vancomycin intermediate-resistant Staphylococcus aureus (VISA) isolated from a patient who never received vancomycin treatment.

Background: With the abuse of antibiotics, the methicillin-resistant Staphylococcus aureus (MRSA) strain became prevalent. Furthermore, Staphylococcus aureus with a character of vancomycin intermediate-resistance (VISA) has been found globally since the first report in Japan. The main objectives of this study were to report a case of VISA isolated from a Chinese patient who had never undergone Vancomycin treatment, and to determine its molecular character.

inhibits the growth of pathogenic fungi: and studies.

The aim of the present study was to investigate the inhibitory effect of (PA) on pathogenic fungi, including (CA), (CT), (CG), (CP) and (CK), and . In total, 24 PA strains were collected from clinical specimens and identified by Gram staining, oxidase production and the API 20NE system. Cross-streak, disk diffusion and co-culture methods were used to observe the inhibitory effect of PA.

Molecular characteristics and virulence factors in methicillin-susceptible, resistant, and heterogeneous vancomycin-intermediate Staphylococcus aureus from central-southern China.

Background: Staphylococcus aureus is a leading cause of nosocomial infections. The purpose of this study was to evaluate the prevalence of methicillin-resistant S. aureus (MRSA) and heterogeneous vancomycin-intermediate S.

The impact of mgrA on progression of Staphylococcus aureus sepsis.

Sepsis induced by Staphylococcus aureus has worse outcome with the appearance of methicillin-resistant Staphylococcus aureus (MRSA) because of multi-resistance to a large group of antibiotics, which may lead to death from septic shock. Pathogenesis of S. aureus infections are involved in the production of a wide variety of virulence factors.

Blocking TREM-1 signaling prolongs survival of mice with Pseudomonas aeruginosa induced sepsis.

TREM-1 is a recently discovered receptor expressed on neutrophils and macrophages. Blocking of TREM-1 signaling improves the survival of mice with bacterial sepsis. However, the precise mechanism by which TREM-1 modulates the inflammatory responses is poorly defined.

Tim-3 ligand galectin-9 reduces IL-17 level and accelerates Klebsiella pneumoniae infection.

T cell immunoglobulin and mucin domain (Tim)-3 is expressed on activated CD4(+) and CD8(+) T cells. Identification of galectin-9 as a ligand for Tim-3 has now firmly established the Tim-3/galectin-9 pathway, which results in apoptosis of effector CD4(+) and CD8(+) T cells. Moreover, Th17 cells are a recently discovered CD4(+) effector T cell, which are important in antimicrobial immunity.