A Bait-and-Hook Hydrogel for Net Tumor Cells to Enhance Chemotherapy and Mitigate Metastatic Dissemination.

: Lung cancer is an aggressive disease with rapid progression and a high rate of metastasis, leading to a significantly poor prognosis for many patients. While chemotherapy continues to serve as a cornerstone treatment for a large proportion of lung cancer patients, expanding preclinical and clinical evidence indicates that chemotherapy may promote tumor metastasis and cause side effects. : We develop an injectable bait-and-hook hydrogel (BH-gel) for targeted tumor cell eradication, which embedded doxorubicin liposomes as cytotoxic agents and CXCL12 as a chemoattractant to capture and kill tumor cells.

Routing and scheduling co-design for holistic software-defined deterministic network.

As a result of the growing complexity of industrial Internet applications, traditional hardware-based network designs are encountering challenges in terms of programmability and dynamic adaptability as they struggle to meet the real-time, high-reliability transmission requirements for the vast quantities of data generated in industrial environments. This paper proposes a holistic software-defined deterministic network (HSDDN) design solution. This solution uses a centralized controller to implement a comprehensive software definition, ranging from the network layer down to the physical layer.

CBLL1 promotes endometrial stromal cell senescence via inhibiting PTEN in recurrent spontaneous abortion.

Recurrent spontaneous abortion (RSA) is a common pregnancy-related disorder. Cbl proto-oncogene like 1 (CBLL1) is an E3 ubiquitin ligase, which has been reported to vary with the menstrual cycle in the endometrium. However, whether CBLL1 is involved in the occurrence and development of RSA remains unclear.

Bearing Rigidity-Based Flocking Control of AUVs via Semi-Supervised Incremental Broad Learning.

Flocking control of autonomous underwater vehicles (AUVs) has been regarded as the basis of many sophisticated marine coordination missions. However, there is still a research gap on the flocking of AUVs in weak communication and complex marine environment. This article attempts to fill up the above research gap from graph theory and intelligent learning perspectives.

Decreased thrombospondin-1 impairs endometrial stromal decidualization in unexplained recurrent spontaneous abortion†.

Inappropriate endometrial stromal decidualization has been implied as an important reason of many pregnancy-related complications, such as unexplained recurrent spontaneous abortion, preeclampsia, and intrauterine growth restriction. Here, we observed that thrombospondin-1, an adhesive glycoprotein, was significantly downregulated in endometrial decidual cells from patients with unexplained recurrent spontaneous abortion. The immortalized human endometrial stromal cell line was used to investigate the possible THBS1-mediated regulation of decidualization.

Effect of maternal serum albumin level on birthweight and gestational age: an analysis of 39200 singleton newborns.

Background: Serum albumin plays a pivotal role in regulating plasma oncotic pressure and modulating fluid distribution among various body compartments. Previous research examining the association between maternal serum albumin levels and fetal growth yielded limited and inconclusive findings. Therefore, the specific influence of serum albumin on fetal growth remains poorly understood and warrants further investigation.

PDE12 disrupts mitochondrial oxidative phosphorylation and mediates mitochondrial dysfunction to induce oral mucosal epithelial barrier damage in oral submucous fibrosis.

Oral submucous fibrosis (OSF) is a chronic oral mucosal disease. The pathological changes of OSF include epithelial damage and subepithelial matrix fibrosis. This study aimed to reveal the epithelial injury mechanism of OSF.

Epigenetic drug screening for trophoblast syncytialization reveals a novel role for MLL1 in regulating fetoplacental growth.

Background: Abnormal placental development is a significant factor contributing to perinatal morbidity and mortality, affecting approximately 5-7% of pregnant women. Trophoblast syncytialization plays a pivotal role in the establishment and maturation of the placenta, and its dysregulation is closely associated with several pregnancy-related disorders, including preeclampsia and intrauterine growth restriction. However, the underlying mechanisms and genetic determinants of syncytialization are largely unknown.

Bearing-Based Robust Formation Tracking Control of Underactuated AUVs With Optimal Parameter Tuning.

This article investigates the control problem of bearing-based formation tracking for underactuated autonomous underwater vehicles (AUVs) considering actuator constraints and unknown disturbances. A leader-follower structure is adopted, where the leaders move with an unknown reference velocity. For the followers, an integrated strategy is proposed, which includes i) a bearing-based control method composed of a reference velocity estimator, a virtual velocity for achieving the desired formation, and an adaptive robust formation controller to track the virtual velocity under disturbances; and ii) a parameter tuning method based on control parameterization approaches and heuristic algorithms.

CD8 T cells in fetal membranes display a unique phenotype, and their activation is involved in the pathophysiology of spontaneous preterm birth.

Preterm labor/birth is the leading cause of perinatal mortality and morbidity worldwide. Previous studies demonstrated that T cells were crucial for maintaining maternal-fetal immune tolerance during the first trimester of pregnancy; however, their phenotypes and functions in labor and delivery remain largely unknown. We recruited three cohorts of women at delivery for T-cell immunophenotyping in the placentas, fetal membranes, umbilical cord blood, and maternal peripheral blood.

DOCK1 insufficiency disrupts trophoblast function and pregnancy outcomes via DUSP4-ERK pathway.

Abnormal trophoblast function is associated with diseases such as recurrent spontaneous abortion, pre-eclampsia, and preterm birth, and endangers maternal and fetal health. However, the underlying regulatory mechanisms remain unclear. In this study, we found DOCK1 expression is decreased in the placental villi of patients with recurrent spontaneous abortion, and that its expression determined the invasive properties of extravillous trophoblasts (EVTs), highlighting a previously unknown role of DOCK1 in regulating EVT function.

An automatic progressive chromosome segmentation approach using deep learning with traditional image processing.

The fully automatic chromosome analysis system plays an important role in the detection of genetic diseases, which in turn can reduce the diagnosis burden for cytogenetic experts. Chromosome segmentation is a critical step for such a system. However, due to the non-rigid structure of chromosomes, chromosomes may curve in any direction, and two or more chromosomes may touch or overlap to form unpredictable chromosome clusters in metaphase chromosome images, leading to automatic chromosome segmentation as a challenge.

Adverse obstetric and perinatal outcomes of patients with history of recurrent miscarriage: a retrospective cohort study.

Objective: To examine the associations between a history of recurrent miscarriage (RM) and adverse obstetric and perinatal outcomes in the subsequent pregnancy that progressed beyond 24 weeks.

Design: Retrospective cohort study.

Setting: A large tertiary maternity hospital.

Communication-Efficient and Collision-Free Motion Planning of Underwater Vehicles via Integral Reinforcement Learning.

Motion planning of underwater vehicles is regarded as a promising technique to make up the flexibility deficiency of underwater sensor networks (USNs). Nonetheless, the unique characteristics of underwater channel and environment make it challenging to achieve the above mission. This article is concerned with a communication-efficient and collision-free motion planning issue for underwater vehicles in fading channel and obstacle environment.

Peroxiredoxin2 regulates trophoblast proliferation and migration through SPIB-HDAC2 pathway.

Adequate proliferation and migration of placental trophoblasts is the prerequisite of a successful pregnancy. Peroxiredoxin2 (Prdx2) is a multi-functional gene involved in various signal events to maintain essential biological functions and normal cellular homeostasis. In this study, substantially lower Prdx2 levels were found in the first trimester cytotrophoblasts of women who suffered from recurrent miscarriage (RM).

Bearing-Based Formation Tracking Control With Time-Varying Velocity Estimation.

This article studies the bearing-based formation tracking control problem of multiple double-integrator agents. A leader-following structure, where the leader moves with the reference dynamics, is adopted. Different from the existing methods, which require complete information of the time-varying reference velocity, in this article, only the time-varying reference orientation information is known by part of the followers and the amplitude of the reference velocity is unknown.

Edge Sensing and Control Co-Design for Industrial Cyber-Physical Systems: Observability Guaranteed Method.

The new generation of the industrial cyber-physical system (ICPS) supported by the edge computing technology facilitates the deep integration of sensing and control. System observability is the key factor to characterize the internal relationship of them. In most existing works, the observability is regarded as the assumption for subsequent sensing and control.

Energy-Efficient Optimal Sensor Scheduling for State Estimation Over Multihop Sensor Networks.

In this article, we consider the power scheduling problem of the multihop transmission with limited power resources. For a discrete-time linear time-invariant process, we consider a more practical scenario where the forward-error-correcting (FEC) coding scheme is utilized. An approximate communication model is introduced to formulate the nonanalytical relationship between the consumption of power and the successful-decoding-probability.

Sensor scheduling for relay-assisted wireless control systems with limited power resources.

In this paper, we investigate the transmission scheduling problem for wireless control systems (WCSs) with limited power resources. Different from the existing works, for a discrete-time linear process, we consider a more practical WCS, where a relay is introduced into the framework for remote transmission and control. To achieve the best control performance of the system, we propose a global optimal offline scheduling algorithm.

A Secure Scheme for Distributed Consensus Estimation against Data Falsification in Heterogeneous Wireless Sensor Networks.

Heterogeneous wireless sensor networks (HWSNs) can achieve more tasks and prolong the network lifetime. However, they are vulnerable to attacks from the environment or malicious nodes. This paper is concerned with the issues of a consensus secure scheme in HWSNs consisting of two types of sensor nodes.

Balancing energy consumption with hybrid clustering and routing strategy in wireless sensor networks.

Multi-hop data collection in wireless sensor networks (WSNs) is a challenge issue due to the limited energy resource and transmission range of wireless sensors. The hybrid clustering and routing (HCR) strategy has provided an effective solution, which can generate a connected and efficient cluster-based topology for multi-hop data collection in WSNs. However, it suffers from imbalanced energy consumption, which results in the poor performance of the network lifetime.

An energy-efficient underground localization system based on heterogeneous wireless networks.

A precision positioning system with energy efficiency is of great necessity for guaranteeing personnel safety in underground mines. The location information of the miners' should be transmitted to the control center timely and reliably; therefore, a heterogeneous network with the backbone based on high speed Industrial Ethernet is deployed. Since the mobile wireless nodes are working in an irregular tunnel, a specific wireless propagation model cannot fit all situations.

Advanced glycation end products induce glomerular endothelial cell hyperpermeability by upregulating matrix metalloproteinase activity.

The present study aimed to investigate the effects of advanced glycation end‑products (AGEs) on the permeability of glomerular endothelial cells (GEnCs) and determine whether enhanced permeability was due to degradation of tight junction (TJ) complexes by matrix metalloproteinases (MMPs). Cultured monolayers of GEnCs were exposed to AGEs at different doses and treatment durations in the presence or absence of the organic MMP‑2/9 inhibitor (2R)‑2‑((4‑biphenyl sulfony‑l)amino)‑3‑phenylproprionic acid) (BiPs). Expression of the TJ proteins occludin and claudin‑5 was determined by western blot analysis and immunofluorescence, while the permeability of the GEnCs was measured using transendothelial electrical resistance and by diffusion of 4 kDa fluorescein isothiocyanate (FITC)‑dextran.

Distributed optimal consensus filter for target tracking in heterogeneous sensor networks.

This paper is concerned with the problem of filter design for target tracking over sensor networks. Different from most existing works on sensor networks, we consider the heterogeneous sensor networks with two types of sensors different on processing abilities (denoted as type-I and type-II sensors, respectively). However, questions of how to deal with the heterogeneity of sensors and how to design a filter for target tracking over such kind of networks remain largely unexplored.