Publications by authors named "Caili Gou"
Article Synopsis
- The study focused on the impact of low-dose esketamine on postoperative delirium (POD) in elderly patients undergoing major surgeries like hip or knee arthroplasties, which can lead to increased health complications.
- Two hundred and sixty patients were randomly assigned to receive either esketamine or a placebo, with the main goal of assessing POD incidence and various related outcomes, such as pain levels and anesthesia effects.
- Results showed no significant difference in POD rates between the esketamine and placebo groups, although the esketamine group experienced more stable hemodynamics and lower pain scores initially, but reported higher rates of postoperative dizziness.
The primary aim of this research was to explore the functions of Wtap and Ythdf1 in regulating neuronal Lipocalin-2 (Lcn2) through m6A modification in traumatic brain injury (TBI). By employing transcriptome sequencing and enrichment analysis, we identified the Wtap/Ythdf1-mediated Lcn2 m6A modification pathway as crucial in TBI. In our in vitro experiments using primary cortical neurons, knockout of Wtap and Ythdf1 led to the inhibition of Lcn2 m6A modification, resulting in reduced neuronal death and inflammation.
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