Publications by authors named "Caihong Yi"
Article Synopsis
- The study focuses on anti-melanoma differentiation-associated gene 5 (Anti-MDA5)-positive dermatomyositis (DM), a serious autoimmune disorder linked to severe lung disease, and highlights the need for better understanding its causes for improved treatments.
- Researchers used single-cell RNA sequencing to analyze blood samples from DM patients and healthy individuals, discovering an increase in certain immune cell types among patients.
- Key findings include a strong type I interferon response and a specific subset of CD14+ monocytes associated with viral infection, suggesting a new, viral-related origin of anti-MDA5 DM and potential targets for future therapies.
Vitamin D-dependent rickets (VDDR) type 1A is a rare autosomal recessive disorder caused by cytochrome P450 family 27 subfamily B member 1 (CYP27B1) mutations and can lead to deficiencies in 1α-hydroxylase activity. The present study describes the case of a 39-year-old male patient who presented with rickets and deformities of limbs. Blood biochemical analysis revealed hypocalcemia and high serum parathyroid hormone (PTH) levels.
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- Acute intermittent porphyria (AIP) is a genetic disorder that affects heme production in the liver and can lead to severe abdominal pain attacks that are hard to manage for some patients.* -
- A 20-year-old woman with recurrent AIP attacks did not improve with standard treatments, but showed significant relief after receiving a year-long treatment with gonadotropin-releasing hormone analogues and estrogen.* -
- The treatment resulted in the woman not experiencing any acute attacks and achieving long-term remission, suggesting this combination could be effective for menstrual-related AIP cases.*
RNA-binding proteins (RBPs) function as master regulators of gene expression. Alterations in their levels are often observed in tumors with numerous oncogenic RBPs identified in recent years. Musashi1 (Msi1) is an RBP and stem cell gene that controls the balance between self-renewal and differentiation.
View Article and Find Full Text PDFBackground: Classic homocystinuria is caused by cystathionine beta synthase deficiency owing to genetic mutations. The most common symptoms are ectopia lentis, osteoporosis, thrombosis, and mental retardation. This disease is prone to misdiagnosis and delayed diagnosis.
View Article and Find Full Text PDFBackground: RNA-binding proteins (RBPs) function as master regulators of gene expression. Alterations in RBP expression and function are often observed in cancer and influence critical pathways implicated in tumor initiation and growth. Identification and characterization of oncogenic RBPs and their regulatory networks provide new opportunities for targeted therapy.
View Article and Find Full Text PDFRNA binding proteins have emerged as critical oncogenic factors and potential targets in cancer therapy. In this study, we evaluated Musashi1 (Msi1) targeting as a strategy to treat glioblastoma (GBM); the most aggressive brain tumor type. Msi1 expression levels are often high in GBMs and other tumor types and correlate with poor clinical outcome.
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