Publications by authors named "Caifeng Zheng"
Although tyrosine kinase inhibitor (TKI) therapy has markedly improved the survival of people with chronic-phase chronic myeloid leukemia (CML), 20% to 30% of people still experienced therapy failure. Data from 1955 consecutive patients with chronic-phase CML diagnosed by the European LeukemiaNet recommendations from 1 center receiving initial imatinib or a second-generation (2G) TKI therapy were interrogated to develop a clinical prediction model for TKI-therapy failure. This model was subsequently validated in 3454 patients from 76 other centers.
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- A study was conducted to compare therapy responses and outcomes among four medications (nilotinib, dasatinib, flumatinib, and imatinib) for newly diagnosed chronic myeloid leukemia (CML) in a practical setting.
- Data from 2,496 patients across 77 centers in China were analyzed, and results showed that the newer treatments had similar effectiveness in terms of overall survival and progression-free survival, but better initial responses and failure-free survival compared to imatinib.
- The findings suggest that while nilotinib, dasatinib, and flumatinib are more effective in achieving early treatment responses, all four medications ultimately offer comparable long-term survival outcomes, which can help
Introduction: Chronic myeloid leukemia (CML) is a chronic disease with treatment-free remission (TFR) increasingly regarded as a feasible goal of treatment. However, various factors may influence adherence to international guidelines for CML management. This study aimed to compare the reporting of care between patients with CML and their treating doctors.
View Article and Find Full Text PDFObjective: To investigate the effect and mechanism of artesunate (ARTS) combined with cytarabine(Ara-C) and/or daunorubicin (DNR) on the proliferation and apoptosis of MV4-11 human mixed-lineage leukemia rearranged（MLL-r） acute myeloid leukemia (AML) cell line.
Methods: CCK-8 assay was used to detect the proliferation effect of individual or in combination of ARTS, DNR, Ara-C on MV4-11 cells. The IC of ARTS, DNR and Ara-C was calculated separately.
The 8p11 myeloproliferative syndrome [EMS] is a rare myeloproliferative disorder which usually develops rapidly with chromosomal translocation of the fibroblast growth factor receptor 1 gene. The gene has 15 fusion partners, including the breakpoint cluster region (BCR) gene on chromosome 22. Of all the tests available, chromosome karyotype determination is the most important for the diagnosis of EMS.
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- The study aimed to enhance the effectiveness of F-FDG PET/CT scans for diagnosing fever of unknown origin (FUO) and inflammation of unknown origin (IUO) in Chinese patients by integrating clinical parameters.
- A total of 253 FUO/IUO patients were analyzed, revealing that specific clinical parameters significantly improved the accuracy of diagnoses, particularly in groups with local uptake lesions and non-specific uptake.
- The combination of clinical factors increased diagnostic accuracy for malignancy and infection predictions, showcasing the importance of integrating clinical data with imaging results.
Article Synopsis
- * A diagnostic tool was developed through analysis of FUO patients in three Chinese hospitals, using logistic regression to create a scoring system based on clinical and lab evaluations.
- * This tool showed promising results with an AUC of 0.83 for distinguishing causes of FUO, indicating it can reliably help predict whether the fever is due to infection or another reason.
Article Synopsis
- The study focused on identifying factors that indicate pathogen invasion to create a model that distinguishes infectious from non-infectious causes of fever of unknown origin (FUO).
- Researchers enrolled 431 patients from January 2014 to September 2017 and identified 26 variables across four categories: host, epidemiological, behavioral, and iatrogenic factors.
- A predictive model was developed using multivariate logistic regression, achieving an AUC of 0.72, with a sensitivity of 0.71 and specificity of 0.63, proving to be useful for screening FUO causes.
For nearly two decades, immunization against the β-amyloid peptide (Aβ) has been investigated as a potential treatment for Alzheimer's disease (AD). Despite some disappointing results in clinic trials, greater significance has been attached by some researchers to exploring the immune effects on pathological and cognitive changes in AD or producing new vaccines of AD. In the previous study, we have made a virus-like particles (Aβ-HBc VLPs) as Aβ vaccine candidate.
View Article and Find Full Text PDFAlzheimer's disease (AD), the most common neurodegenerative disorder that gradually destroys memory and cognitive abilities in the elderly, makes a huge emotional and economic burden on the patients and their families. The presence of senile plaques and the loss of cholinergic neurons in the brain are two neuropathological hallmarks of AD. Maternal separation (MS) is an animal paradigm designed to make early life stress.
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