Publications by authors named "CaiXia Liu"

The accumulation of intermediate products on the catalyst surface caused by insufficient oxygen activity is an important reason for the poor activity of catalysts towards oxygenated volatile organic compounds (OVOCs). CoMnO@MnO heterogeneous catalysts were fabricated to decipher the interfacial oxygen activation mechanism for efficient acetone oxidation. Experimental and theoretical explorations revealed that oxygen vacancies were easily formed at the interface.

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Biomolecular condensates (BCs) are crucial membraneless organelles formed through the process of liquid-liquid phase separation (LLPS) involving proteins and nucleic acids. These LLPS processes are tightly linked with essential cellular activities. Stress granules (SGs), functioning as cytoplasmic BCs, play indispensable roles in maintaining cellular homeostasis and are implicated in diseases like cancers and neurodegenerative disorders.

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Objective: This study aims to investigate the pathogenic role of TBX20 gene mutations in congenital heart disease (CHD), evaluate their impact on cardiac development and function, and quantify the association between TBX20 gene mutations and CHD risk through meta-analysis.

Methods: Genetic screening of 353 CHD patients and 350 healthy children was conducted using high-throughput sequencing technology to identify TBX20 gene mutations. Homology modeling and molecular dynamics simulations were employed to assess the mutations' effects on the structure and function of the TBX20 protein.

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Article Synopsis
  • Ibrutinib, a drug commonly used for B-cell lymphoma, has shown great effectiveness but is linked to serious heart issues like atrial fibrillation and ventricular arrhythmias, raising concerns in both cardio-oncology and hematology.
  • While atrial fibrillation caused by ibritunib is well understood, the mechanisms behind ventricular arrhythmias are still being researched, leading to variability in their reported incidence due to factors like under-recognition.
  • The article aims to provide a thorough overview of the epidemiology, mechanisms, and clinical implications of ibritunib-induced ventricular arrhythmias, suggesting management strategies for patients on this treatment.
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Background: In the context of global population aging and the rapid development of information technology, the demand for Internet Plus Home Care Nursing (Internet+ HCN) services have been on the rise, especially in China. Internet+ HCN services have the potential to maximize existing human resources to counter the shortage of medical healthcare services. However, at present, Internet+ HCN services are difficult to scale due to the lack of standardized service quality governance.

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  • - The study focuses on improving callus induction methods to derive a doubled haploid (DH) callus line from poplar anthers, addressing gaps in the previously sequenced genomes.
  • - Using long-read sequencing, researchers successfully assembled a nearly complete genome of 412.13 Mb with only seven gaps, significantly improving the reference genome for poplars by annotating 34,953 protein-coding genes.
  • - This new telomere-to-telomere (T2T) genome assembly enhances understanding of poplar genetics and evolutionary studies, particularly through the identification of centromeric regions and their high-order repeats.
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Climate change has exacerbated outbreaks of forest pests worldwide. In recent years, bark beetles have caused significant damage to coniferous forests of the Northern Hemisphere. bark beetles are widely distributed secondary pests.

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Background: Type A acute aortic dissection, an aggressive and highly fatal disease, is particularly common among pregnant women and foetuses. This disease often occurs during the third trimester of pregnancy and the postpartum period.

Case Report: This case involves a female who was 20 weeks pregnant with type A acute aortic dissection.

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  • A study assesses the current misuse of drugs for treating hypoproteinemia and evaluates 12 types of amino acid injections to identify the most effective options for therapy.
  • The research compared the effectiveness of different amino acid compositions against human serum albumin and established benchmarks, highlighting variations in synthetic values and similarities to whole egg protein and FAO/WHO standards.
  • The findings recommend specific amino acid injections based on patients' liver and kidney function: normal-function patients should use compound balanced injections, those with liver abnormalities should opt for 3AA, patients with renal issues should select 9AA, and trauma cases should use 18AA-VII.
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  • The study investigates the genetic relationship between human gut microbiota, osteoarthritis (OA), and the impact of OA-related medications, utilizing bidirectional Mendelian randomization (MR) techniques.
  • By analyzing data from large-scale genome-wide association studies, the research identifies significant genetic associations indicating certain gut microbiota taxa increase or decrease the risk of hip and knee OA.
  • Results demonstrate that the associations remain robust even after adjusting for medication use, suggesting a potential causal link between gut microbiome composition and the risk of developing osteoarthritis.
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Background: As dementia progresses, patients exhibit various psychological and behavioral symptoms, imposing a significant burden on families and society, including behavioral and psychological symptoms of dementia. However, caregivers lack professional care knowledge and skills, making it difficult for them to effectively cope with the diverse challenges of caregiving. Therefore, it is necessary to provide caregivers with professional knowledge and skills guidance.

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Ischemic heart disease refers to the imbalance between the supply and demand of myocardial blood; it has various causes and results in a class of clinical diseases characterized by myocardial ischemia (MI). In recent years, the incidence of cardiovascular disease has become higher and higher, and the number of patients with ischemic heart disease has also increased year by year. Traditional treatment methods include drug therapy and surgical treatment, both of which have limitations.

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  • The study aimed to assess the caring behavior of nurses in Sierra Leone and identify factors influencing it, addressing a gap in existing research.
  • Conducted from October to December 2022, the research involved 360 nurses across 12 hospitals and utilized various scales to measure caring behavior, resilience, job satisfaction, and anxiety.
  • The findings revealed a moderate level of caring behavior, positively linked to job satisfaction and resilience, while negatively associated with anxiety; it highlighted the need for improved working conditions to enhance nurses' caring behavior.
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The current research was designed to investigate the impact of whole-process high-quality nursing on acute pancreatitis (AP) patients' quality of life as well as the mechanism of miR-126-5p/HOXC8 axis promoting AP progression. One hundred AP patients admitted to our hospital were chosen and separated into control group (CG, n=50) and study group (SG, n=50). The CG took the routine nursing, while the SG adopted the whole-process high-quality nursing.

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Mountainous regions are vital biodiversity hotspots with high heterogeneity, providing essential refugia for vegetation. However, climate change threatens this diversity with the potential homogenization of the distinct environmental conditions at different elevations. Here, we used a time-series (1985-2023) of Normalized Difference Vegetation Index (NDVI) from Landsat archives (30 m) to quantify vegetation changes across an elevation gradient on Himalaya Mountain.

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Distal third tibial fractures associated with anterior soft tissue compromise are a predictor of more complications and poor prognosis. The study aimed to introduce the treatment of such fractures through the posterolateral approach. From March 2020 and January 2022, 32 patients with distal third tibial fractures were plated through the posterolateral approach due to concurrent closed anterior soft tissue compromise.

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Drought stress is a critical environmental factor that significantly impacts plant growth and productivity. However, the transcriptome analysis of differentially expressed genes in response to drought stress in Abel. is still unclear.

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Prior research on cascading failures within interdependent networks has predominantly emphasized the coupling of nodes. Nevertheless, in practical networks, interactions often exist not just through the nodes themselves but also via the connections (edges) linking them, a configuration referred to as edge-coupled interdependent networks. Past research has shown that introducing a certain percentage of reinforced nodes or connecting edges can prevent catastrophic network collapses.

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With the development of organic electrochemical synthesis, a series of notable achievements have been made in electrochemical Ritter amination reactions, which have enriched the methods available for constructing C-N bonds. In this review, electrochemical Ritter amination reactions are introduced based on the classification of reaction substrates, including olefins, aromatics, alkylbenzenes, and the less reported carboxylic acids, ketones, sulfides, and alkanes. The application of electrochemical technology to Ritter reactions has improved the harsh conditions of the traditional reactions, and extended the substrate scope and the structural diversity of the products.

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In reality, pairwise interactions are no longer sufficient to describe the higher-order interactions between nodes, such as brain networks, social networks, etc., which often contain groups of three or more nodes. Since the failure of one node in a high-order network can lead to the failure of all simplices in which it is located and quickly propagates to the whole system through the interdependencies between networks, multilayered high-order interdependent networks are challenged with high vulnerability risks.

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Listeria monocytogenes () is a foodborne pathogen that causes listeriosis in humans and other animals. Surface proteins with the LPXTG motif have important roles in the virulence of . Lmo0159 is one such protein, but little is known about its role in virulence, motility, and biofilm formation.

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To explore the role of the membrane permease ⅡB (EⅡB) gene of pathogenicity island 4 (LIPI-4) in the virulence of , both an EⅡB deletion strain (∆EⅡB) and a complemented strain were constructed. In vitro experiments demonstrated that EⅡB deletion affected the biofilm formation ability of the wild-type strain (Lm928). Moreover, this deletion decreased the intracellular proliferation abilities of .

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Article Synopsis
  • The airway epithelium acts as a barrier between the body and the environment, frequently facing harmful stimuli that can trigger inflammation and lead to various lung diseases.
  • This study focused on Chloride intracellular channel 4 (CLIC4), which is highly present in epithelial cells, to explore its role in regulating the inflammatory response caused by lipopolysaccharide (LPS).
  • Findings revealed that LPS lowers CLIC4 levels and, when CLIC4 was silenced, inflammation increased; however, overexpressing CLIC4 alongside LPS reduced inflammation, suggesting that CLIC4 helps manage this response through the regulation of intracellular chloride ions.
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