Patients with malignant tumors have significantly lower levels of Protein Z (PZ) and higher levels of coagulation factors FXII:C, FX:C, and FX:Ag compared to healthy individuals, suggesting a hypercoagulable state.
* The study involved analyzing plasma levels of PZ and various coagulation factors in both tumor patients and healthy controls, revealing a clear correlation between PZ levels and coagulation abnormalities.
* Lower PZ levels were particularly noted in more advanced cancer stages (III-IV), indicating its potential role as a clinical marker for tumor progression and coagulation risk.
The study aimed to investigate how protein Z (PZ) levels change in patients with cardio-cerebral thrombotic diseases and their relationship with factor X (FX) levels.
Results showed that PZ levels were significantly lower in patients with acute ischemic stroke (AIS) and acute myocardial infarction (AMI) compared to healthy individuals, while FX levels were elevated in these patient groups.
The decrease in PZ was linked to the severity and recurrence of the diseases, with age also playing a role in PZ levels, but no significant correlation was found with gender.