Publications by authors named "Cai-Xia Cao"
Background: Hyperglycemia exacerbates brain damage caused by cerebral ischemia. Neuroinflammation may play a role in mediating such enhanced damage. The objectives of this study were to examine the mRNA and protein levels and cell type distribution of ICAM-1 after cerebral ischemia in normo-and diabetic hyperglycemic rats.
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- This study aimed to compare the effectiveness of continuous subcutaneous insulin aspart infusion (CSII) versus multiple daily injections (MDI) using long-acting insulin analogues (glargine or detemir) for poorly controlled type 2 diabetes patients.
- 119 patients were randomly divided into three groups: CSII (Group A), glargine-based MDI (Group B), and detemir-based MDI (Group C).
- Results showed that Group A achieved better blood glucose control in a shorter time with lower insulin doses compared to Groups B and C, with no significant differences between the glargine and detemir groups.
Aim: To evaluate the correlation between nonalcoholic fatty liver disease (NAFLD) and microvascular complications in type 2 diabetes mellitus (T2DM).
Methods: Data were obtained from 1217 inpatients with T2DM (757 females, 460 males; aged 63.39 ± 12.
Metformin appears to be involved in altering energy expenditure and thermogenesis, and could affect hypothalamic feeding circuits. However, it is not clear whether metformin is able to cross the blood-brain barrier (BBB) to reach the hypothalamus and exert a direct effect on the central nervous system. Here we show the presence of metformin in cerebrospinal fluid (CSF) of diabetic rats administered orally with metformin which was confirmed by detecting the concentration of metformin with liquid chromatography-tandem mass spectrometry.
View Article and Find Full Text PDFObjective: To compare the mRNA, protein expression of long leptin receptor (Ob-Rb) in human adrenal tissues and tumors and observe the plasma level of leptin in primary aldosteronism (PA), cortisol-secreting tumors (CS) and pheochromocytomas (PHEO).
Methods: Total RNA and protein were extracted from 6 normal human adrenal glands, 10 CS, 20 PHEO; and 14 aldosterone-producing adenomas (APA) (RNA), 10 APA (protein); plasma samples were drawn from 20 controls, 15 PHEO, 29 PA and 11 CS.
Results: The mRNA and protein of Ob-Rb were widely expressed in human adrenal glands and tumors.
Objective: To investigate the clinical and genetic features of a Chinese family with von Hippel-Lindau (VHL) disease revealed by bilateral pheochromocytoma.
Methods: The proband and other members in a Chinese family with familial pheochromocytoma were clinically evaluated and followed up. Genomic DNA extracted from the peripheral blood of 8 family members (including 3 patients) was amplified by polymerase chain reaction (PCR) and the PCR products were directly sequenced.