Publications by authors named "Cai-Tao Chen"
Studies in murine experimental models have made significant contributions to the understanding of asthma pathophysiology and the discovery of innovative therapeutic approaches. Nonetheless, there is a plethora of options available for selecting mouse strains, sensitization methods, challenge routes and doses, as well as approaches to evaluating host response in murine asthma model protocols. Due to the diversity of models employed, comparing results across different studies proves exceedingly challenging.
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- Aerobic training is key for helping COPD patients recover respiratory function, but the specifics of how it works are still unclear; using transcriptomics may help reveal these mechanisms.
- A study involved mice subjected to cigarette smoke followed by exercise, finding that exercise improved some lung functions, but had limited effects on severely damaged lung areas.
- While the exercise linked to numerous gene changes related to inflammation and metabolism, more research is needed to establish a direct cause-and-effect connection with improvements in lung function.
Discovery of zolinium TSG1180 as a novel agonist of transgelin-2 for treating asthma.
Biomed Pharmacother
November 2023
Article Synopsis
- Asthma is a complicated respiratory disease that significantly impacts individuals and society, often not fully controllable with existing medications like β-agonists.
- Researchers identified a zolinium compound, TSG1180, which strongly interacts with Transgelin-2, a potential target for alleviating asthma symptoms, demonstrating effective results in various assays.
- TSG1180 not only relaxed airway smooth muscle cells in vitro but also significantly reduced pulmonary resistance in a mouse model, indicating its potential as a new treatment option for asthma that works specifically through Transgelin-2.
Objective: Asthma is a highly prevalent respiratory disease that remains difficult to control. Acupuncture, as an important alternative therapeutic modality in preventing and treating asthma, is widely used in the world due to its promising efficacy and safety. Although acupoint selection and combinations are critical to therapeutic effects of acupuncture, its fundamental rules for asthma have not been fully understood.
View Article and Find Full Text PDFPurpose: Cyclophilin A (CypA) inhibits CD4 T cell signal transduction via interleukin-2-inducible T-cell kinase (Itk), a tyrosine kinase required for T helper (Th) 2 cells function. Furthermore, mice with CypA silencing developed allergic diseases associated with increased Th2 cytokines production. CD4 T cells with a Th2-cytokine pattern have been demonstrated to have a pivotal role in the pathogenesis of asthma.
View Article and Find Full Text PDFBackground: Acupuncture is widely used for the treatment of chronic pain. Different protocols of acupuncture practice exist and lack agreement on the optimal schedule of acupuncture treatment.
Objective: To review the appropriate acupuncture treatment schedule for chronic pain.