Publications by authors named "Cai-Shi Liao"
Article Synopsis
- Developmental and epileptic encephalopathy (DEE) shows genetic diversity, and this study focused on three cases linked to biallelic variants in the SZT2 gene, known as DEE18.
- Analysis included trio-whole exome sequencing and simulations, revealing that the identified variants could structurally affect the SZT2 protein, potentially leading to increased mTORC1 signaling and seizures.
- The research highlights the correlation between the severity of developmental disorders and the type of SZT2 variants, underscoring the importance of genetic testing for better diagnosis and individualized treatment options for DEE patients.
[Effects of bacterial lysates and all trans-retinoic acid on airway inflammation in asthmatic mice].
Zhongguo Dang Dai Er Ke Za Zhi
June 2018
Objective: To observe the effects of bacterial lysates (OM-85BV) and all trans-retinoic acid (ATRA) on airway inflammation in asthmatic mice, and to investigate the immunoregulatory mechanism of OM-85BV and ATRA for airway inflammation in asthmatic mice.
Methods: Forty female BALB/c mice were randomly divided into five groups: normal control, model, OM-85BV, ATRA, and OM-85BV+ATRA. A bronchial asthma model was established by intraperitoneal injection of ovalbumin (OVA) for sensitization and aerosol challenge in all mice except those in the normal control group.