Regulation of candidalysin underlies Candida albicans persistence in intravascular catheters by modulating NETosis.

Candida albicans is a leading cause of intravascular catheter-related infections. The capacity for biofilm formation has been proposed to contribute to the persistence of this fungal pathogen on catheter surfaces. While efforts have been devoted to identifying microbial factors that modulate C.

Convergent and divergent roles of the glucose-responsive kinase SNF4 in .

The sucrose non-fermenting 1 () complex is a heterotrimeric protein kinase complex that is an ortholog of the mammalian AMPK complex and is evolutionally conserved in most eukaryotes. This complex contains a catalytic subunit (Snf1), a regulatory subunit (Snf4) and a scaffolding subunit (Sip1/Sip2/Gal73) in budding yeast. Although the function of AMPK has been well studied in and , the role of AMPK in has never been investigated.

Antimicrobial Actions and Applications of Chitosan.

Chitosan is a naturally originating product that can be applied in many areas due to its biocompatibility, biodegradability, and nontoxic properties. The broad-spectrum antimicrobial activity of chitosan offers great commercial potential for this product. Nevertheless, the antimicrobial activity of chitosan varies, because this activity is associated with its physicochemical characteristics and depends on the type of microorganism.

maintains mitochondrial function and is required for chitosan resistance, invasive growth, biofilm formation and virulence in .

is the most prevalent fungal pathogen in humans, particularly in immunocompromised patients. In this study, by screening a mutant library, we first identified that the gene, an ortholog of required for mitochondrial respiration, mediates chitosan resistance. Upon treatment with 0.

Evaluation of Biofilm Formation in Using a Silicone-Based Platform with Synthetic Urine Medium.

Molecular mechanisms of biofilm formation in and current methods for biofilm analyses in this fungal pathogen are limited. (2) Methods: Biofilm biomass and crystal violet staining of the wild-type and each gene mutant strain of were evaluated on silicone under synthetic urine culture conditions. (3) Results: Seven media were tested to compare the effects on biofilm growth with or without silicone.