Publications by authors named "Cai-Li Han"
[Molecular mechanism of resveratrol combined with irinotecan in treatment of colorectal cancer].
Zhongguo Zhong Yao Za Zhi
April 2023
Article Synopsis
- - The study explored how resveratrol (RES) combined with irinotecan (IRI) impacts colorectal cancer (CRC) using various scientific analyses, including target identification and protein interaction networks.
- - Analysis revealed 63 potential targets for the combined treatment, focusing on mechanisms like protein phosphorylation and involvement in key signaling pathways related to cancer metabolism.
- - Key findings identified PIK3CA, EGFR, and IGF1R as core targets, with positive correlations to immune response in CRC, and in vitro results showed a significant reduction in cell proliferation with the combination treatment.
In recent years, the clinical treatment of colorectal cancer(CRC) has made great progress, but chemoresistance is still one of the main reasons for reducing the survival rate of patients with colorectal cancer. Therefore, ameliorating chemotherapy resis-tance is an urgent problem to be solved. The purpose of this study was to investigate the regulatory role and related molecular mechanisms of hydroxysafflor yellow A(HSYA) in colorectal cancer cell proliferation, migration, and 5-fluorouracil(5-FU) chemoresistance.
View Article and Find Full Text PDFBackground: The goal of this study was to investigate whether ceftriaxone combination therapy is associated with better clinical outcomes than respiratory fluoroquinolone monotherapy for adults with community-acquired pneumonia (CAP). We conducted a meta-analysis of published studies.
Methods: Using the PubMed, EMBASE, and Cochrane Library databases, we performed a literature search of available randomized controlled trials (RCTs) published as original articles before September 2017.
Aim: To investigate the effects of a new derivative of bisphosphonates, [2-(6-aminopurine-9-yl)-1-hydroxy-phosphine acyl ethyl] phosphonic acid (CP), on human gastric cancer.
Methods: Human gastric cancer cell lines (SGC-7901, BGC-823, MKN-45, and MKN-28) and human colon carcinoma cell lines (LoVo and HT-29) were tested. Cell growth was determined using the MTT assay.
Objective: To investigate the expression of cyclooxygenase-2 (COX-2), human mut-l homologue 1 (hMLH1) and human mut-s homologue 2 (hMSH2) proteins in human paired gastric carcinoma (GC) and adjacent normal mucosa, and analyze their relationship with microsatellite instability (MSI).
Methods: The protein expressions were examined by western blotting. Five MSI loci were assessed by PCR.