[Hsa-let-7b-5p Inhibits Proliferation of Human Leukemia THP-1 Cells via FTO/mA/MYC Signaling Pathway].

Objective: To investigate the down-regulation effect of let-7b-5p on the expression of FTO in acute myeloid leukemia cell line THP-1 and inhibitory effect on THP-1 proliferation via mA/MYC signaling pathway.

Methods: The acute myeloid leukemia cell line THP-1 and the normal human peripheral blood mononuclear cells (PBMNC) were selected as subjects. The expression of let-7b-5p and FTO mRNA in those cells was detected by qPCR, further the expression of FTO protein in those cells was detected by Western blot.