Electrochemical Ni-Catalyzed Decarboxylative C(sp )-N Cross-Electrophile Coupling.

A new electrochemical transformation is presented that enables chemists to couple simple alkyl carboxylic acid derivatives with an electrophilic amine reagent to construct C(sp )-N bond. The success of this reaction hinges on the merging of cooperative electrochemical reduction with nickel catalysis. The chemistry exhibits a high degree of practicality, showcasing its wide applicability with 1°, 2°, 3° carboxylic acids and remarkable compatibility with diverse functional groups, even in the realm of late-stage functionalization.

Multi-Type Missing Imputation of Time-Series Power Equipment Monitoring Data Based on Moving Average Filter-Asymmetric Denoising Autoencoder.

Supervisory control and data acquisition (SCADA) systems are widely utilized in power equipment for condition monitoring. For the collected data, there generally exists a problem-missing data of different types and patterns. This leads to the poor quality and utilization difficulties of the collected data.

The prevalence and effects of treatments of rapidly progressive interstitial lung disease of dermatomyositis/polymyositis adults: A systematic review and meta-analysis.

Rapidly progressive interstitial lung disease (RP-ILD) clearly harms the prognoses of dermatomyositis/polymyositis (DM/PM) patients, however there is a dearth of numerical prevalence and therapy comparison in this field. Therefore, the purpose of this study was to determine the prevalence of RP-ILD in DM/PM patients and compare prognoses, including remission rate and survival data, between treatments. Studies with reports of RP-ILD in DM/PM patients and studies with definite remission and/or survival data of DM/PM-RP-ILD were included in the study.

Enantioselective Deaminative Alkylation of Amino Acid Derivatives with Unactivated Olefins.

Herein, we report the first Ni-catalyzed enantioselective deaminative alkylation of amino acid and peptide derivatives with unactivated olefins. Key for success was the discovery of a new sterically encumbered bis(oxazoline) ligand backbone, thus offering a de novo technology for accessing enantioenriched - linkages via C-N functionalization. Our protocol is distinguished by its broad scope and generality across a wide number of counterparts, even in the context of late-stage functionalization.

Clinical remission of rheumatoid arthritis in a multicenter real-world study in Asia-Pacific region.

Background: Clinical remission is an attainable goal for Rheumatoid Arthritis (RA). However, data on RA remission rates from multinational studies in the Asia-Pacific region are limited. We conducted a cross-sectional multicentric study to evaluate the clinical remission status and the related factors in RA patients in the Asia-Pacific region.

Effect of sustained intensive therapy with disease modifying anti-rheumatic drugs in rheumatoid arthritis: a 5-year real-world consecutive study.

Background: Intensive therapy with disease modifying anti-rheumatic drugs (DMARDs) has been reported to improve the outcomes of rheumatoid arthritis (RA). However, real-world study on the effect of intensive therapy on RA sustained remission is still lacking. This study aimed to investigate the outcome of sustained intensive DMARD therapy (SUIT) for RA in a real-world 5-year consecutive cohort.

Photoinduced Hydroxylation of Organic Halides under Mild Conditions.

Presented in this paper is photoinduced hydroxylation of organic halides, providing a mild access to a range of functionalized phenols and aliphatic alcohols. These reactions generally proceed under mild reaction conditions with no need for a photocatalyst or a strong base and show a wide substrate scope as well as excellent functional group tolerance. This work highlights the unique role of NaI that allows a challenging transformation to proceed under mild reaction conditions.

On the Performance of Random Cognitive mmWave Sensor Networks.

This paper investigates the secrecy performance of a cognitive millimeter wave (mmWave) wiretap sensor network, where the secondary transmitter (SU-Tx) intends to communicate with a secondary sensor node under the interference temperature constraint of the primary sensor node. We consider that the random-location eavesdroppers may reside in the signal beam of the secondary network, so that confidential information can still be intercepted. Also, the interference to the primary network is one of the critical issues when the signal beam of the secondary network is aligned with the primary sensor node.

Secure Transmission in mmWave Wiretap Channels: On Sector Guard Zone and Blockages.

Millimeter-wave (mmWave) communication is one of the key enabling technologies for fifth generation (5G) mobile networks. In this paper, we study the problem of secure communication in a mmWave wiretap network, where directional beamforming and link blockages are taken into account. For the secure transmission in the presence of spatially random eavesdroppers, an adaptive transmission scheme is adopted, for which sector secrecy guard zone and artificial noise (AN) are employed to enhance secrecy performance.

The deubiquitinase OTUD5 regulates Ku80 stability and non-homologous end joining.

The ability of cells to repair DNA double-strand breaks (DSBs) is important for maintaining genome stability and eliminating oncogenic DNA lesions. Two distinct and complementary pathways, non-homologous end joining (NHEJ) and homologous recombination (HR), are employed by mammalian cells to repair DNA DSBs. Each pathway is tightly controlled in response to increased DSBs.

Clinical deep remission and related factors in a large cohort of patients with rheumatoid arthritis.

Background: Clinical remission is the treatment target in rheumatoid arthritis (RA). This study aimed to investigate clinical remission and related factors in a large cohort of patients with RA.

Methods: This study composed of 342 patients with RA.

Analyzing Power Beacon Assisted Transmission with Imperfect CSI in Wireless Powered Sensor Networks.

This paper proposes the maximal ratio transmission (MRT) and maximal ratio combining (MRC) protocols for the power beacon (PB) assisted wireless powered sensor networks and analyzes the impact of the imperfect channel state information (CSI) on the performance using the Markov chain theory. The wireless powered sensor chooses to transmit information to the destination or harvest energy from the PB when its energy can or cannot supply a transmission, respectively. The energy arrival and departure of the sensor is characterized, and the analytical expressions of the network transmit probability, and effective and overall ergodic capacities are formulated and derived.

Secure Transmission for Simultaneous Wireless Information and Power Transfer in AF Untrusted Relay Networks.

This paper investigates secure communications of energy harvesting untrusted relay networks, where the destination assists jamming signal to prevent the untrusted relay from eavesdropping and to improve the forwarding ability of the energy constrained relay. Firstly, the source and the destination transmit the signals to the relay with maximal ratio transmission (MRT) technique or transmit antenna selection (TAS) technique. Then, the destination utilizes maximal ratio combining (MRC) technique or receive antenna selection (RAS) technique to receive the forwarded information.

Loss of Smad7 Promotes Inflammation in Rheumatoid Arthritis.

Smad7 is an inhibitory Smad and plays a protective role in many inflammatory diseases. However, the roles of Smad7 in rheumatoid arthritis (RA) remain unexplored, which were investigated in this study. The activation of TGF-β/Smad signaling was examined in synovial tissues of patients with RA.

Secure Transmission of Cooperative Zero-Forcing Jamming for Two-User SWIPT Sensor Networks.

In this paper, the secrecy performance of the two-user simultaneous wireless information and power transfer (SWIPT) sensor networks is studied and a novel secure transmission scheme of cooperative zero-forcing (ZF) jamming is proposed. The two sensors opportunistically conduct the SWIPT and cooperative ZF jamming, respectively, where the energy required for jamming the eavesdropper is provided by the SWIPT operation so as to keep the energy balance at the sensors in the long run. By deriving the exact closed-form expressions of the secrecy outage probability and the secrecy throughout, we provide an effective approach to precisely assess the impacts of key parameters on the secrecy performance of the system.

Association of OPG gene polymorphism with susceptibility to rheumatoid arthrits in Chinese Han.

Aim: To investigate the association of osteoproterin (OPG) gene polymorphisms 163A/G (rs3102735), 245T/G (rs3134069) with susceptibility to rheumatoid arthritis (RA) in Chinese Han population.

Objective: To study the correlation between the disease of rheumatoid arthritis (RA) in Chinese Han group and the association of osteoproterin (OPG) gene polymorphisms 163A/G(rs3102735) and 245T/G (rs3134069). Approaches: 205 RA patients and 171 healthy control subjects were participated into this study.

[Expression of transforming growth factor beta 1 and conection tissue growth factor in ankylosing spondylitis].

Objective: To investigate the expressions of transforming growth factor beta 1(TGF-β1) /smad, connective tissue growth factor (CTGF), collagen I and collagen III in ankylosing spondylitis (AS).

Methods: Thirty patients with AS were included in the study. All the patients were performed with computed tomography-guided needle biopsy in sacroiiliac joint.

[Preliminary study on single nucleotide polymorphisms and linkage disequilibrium in promoter region of fibrinogen B beta gene].

Objective: To investigate the distribution characters and linkage disequilibrium of single nucleotide polymorphisms (SNPs) -148C/T, -455G/A and -854G/A in the promoter region of fibrinogen B(FGB) beta gene.

Methods: Genotype and allele frequencies of FGB beta gene were examined by polymerase chain reaction-restriction fragment length polymorphism and nucleotide sequencing methods in 377 Chinese southern Han individuals. Three FGB beta SNPs Hardy-Weinberg equilibrium and linkage disequilibrium were analyzed with population genetics methods.