Publications by authors named "Cai Y"

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  • The study focused on creating a pharmacokinetic model for the antibiotic linezolid in premature neonates to optimize its administration.
  • Blood concentration data were collected from 54 premature neonates using LC-MS/MS, and a population pharmacokinetic model was developed using nonlinear mixed effects modeling.
  • The findings indicated that the ideal dosing regimen varies based on the neonates' body surface area, with specific mg/kg dosages recommended for achieving effective therapeutic levels.
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Diffusive gradients in thin films (DGT) technique is renowned for passive sampling but not for rapid analysis, whereas surface-enhanced Raman spectroscopy (SERS) excels in ultrasensitive detection but is limited by substrate contamination from complex matrices. Here, a hierarchical nanostructure of silver (Ag) mirror-supported large Ag nanoparticles (∼120 nm) was grown in polyacrylamide hydrogel with a restricted pore size (PAM/Ag mirror/AgNPs) to serve as both the DGT binding phase and the SERS substrate. The substrate exhibited a maximum electric field enhancement factor of 9.

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Apportioning pollution sources under compound pollution conditions is challenging in river pollution source analysis. The positive matrix factorization (PMF) model is widely used to analyze river pollution sources. However, the identification of pollutants in this model relies primarily on the subjective experience of the researchers, leading to ineffective identification of different contaminants from similar sources.

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  • Danlou tablets (DLTs) are commonly used in China for treating coronary heart disease, but their effectiveness for patients with acute coronary syndrome (ACS) undergoing PCI needs more research.
  • This study was a multicenter trial with 936 patients from 40 centers in China, comparing those who took DLTs with those who received conventional medicine over 36 months.
  • Results showed no significant difference in key health outcomes (like cardiac death or rehospitalization) between the DLT group and the conventional medicine group.
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  • Scientists found that tiny germs called microbiota inside tumors can affect how our immune system fights cancer.
  • They created a tool called MicroEpitope that collects and studies information about these germ proteins in 24 types of cancer.
  • This tool helps researchers learn more about how these proteins work and could lead to better ways to treat cancer.
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Cocatalyst is of paramount significance to provide fruitful active sites for suppressing the spatial charge recombination toward boosted photocatalysis. Up to date, exploration of robust and stable cocatalysts is remained challenging. Inspired by the intrinsic merits of single-atom catalysts (SACs), such as distinctive electronic structure and high atomic utilization efficiency, single-atom/transition metal chalcogenides (TMCs) is utilized as a model to synthesize CdS-Pd single-atom catalyst (CdS-PdSA) heterostructures.

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Acute coronary syndromes, such as myocardial infarction (MI), lack effective therapies beyond heart transplantation, which is often hindered by donor scarcity and postoperative complications. Human induced pluripotent stem cells (hiPSCs) offer the possibility of myocardial regeneration by differentiating into cardiomyocytes. However, hiPSC-derived cardiomyocytes (hiPSC-cardiomyocytes) exhibit fetal-like calcium flux and energy metabolism, which inhibits their engraftment.

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  • Organic matter (OM) significantly influences biogeochemical cycles, particularly in geothermal environments, but its molecular composition and effects on microbial communities were previously unclear.
  • The study identified a diverse range of OM components in geothermal water and sediment, revealing thousands of unique compounds and highlighting the prevalence of sulfur-containing organic compounds in these ecosystems.
  • Findings indicated that various OM fractions affect microbial community structure, with notable connections to specific microbial groups, underscoring OM's role in carbon cycling and potential implications for global climate change.
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Microbial aerosol contamination is a common problem in poultry farms, posing potential health risks to poultry and their caretakers. Exploring the distribution and diversity of the microbial community in poultry farm aerosols is crucial for effective mitigation strategies. The composition of bacterial and fungal aerosols is poorly understood, particularly the prevalence of potential pathogenic microorganisms in fine particulate matter (PM) in various types of poultry houses.

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Large cyanobacterial colonies as visible particles floating on the water surface provide different microbial niches from small particles suspended in the water column in eutrophic freshwaters. However, functional potential differences among microbes colonizing on these contrasting particles are not well understood. Here, the metatranscriptome of microbes inhabiting these two kinds of particles during cyanobacterial bloom (dominated by Microcystis spp.

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Background: High myopia is a common cause of vision loss. Age is an important factor in the development of high myopia. However, the effect of age on aqueous humor proteins in the context of high myopia is unknown.

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Purpose: Employees within organizations actively pursue and maintain their workplace well-being. Although there are current studies that have examined the linking inclusive leadership to employee workplace well-being, the underlying intrinsic link between the two remains unclear. On the basis of self-determination theory, this research examined the relationship between inclusive leadership, vigor, supervisor developmental feedback, and workplace well-being.

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  • - The study investigates whether atypical chronic myeloid leukemia (aCML) and chronic neutrophilic leukemia (CNL) should be classified as the same disease, examining 36 aCML and 18 CNL cases.
  • - Findings show significant differences in blood counts, genetics, and clinical outcomes between the two leukemias, including lower hemoglobin and platelet levels in aCML, and a higher prevalence of abnormal karyotypes.
  • - The overall survival rate for aCML patients was notably lower (7.3 months) compared to CNL patients, supporting the idea that these two conditions are distinct and require separate classifications.
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  • A trapezoidal cage (1) was developed, allowing it to selectively recognize fluoride ions (F) even in the presence of many other anions.
  • The selectivity for fluoride is reported to be greater than 1000 times ( > 1000).
  • Various analytical methods, including NMR, fluorescence, UV-vis, and HRMS, were used to study the binding characteristics and affinity of the cage with fluoride, demonstrating a binding affinity of around ∼10 M.
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  • The study focuses on using echocardiographic parameters to predict left atrial low-voltage areas (LA-LVAs) in patients with non-valvular atrial fibrillation (NVAF), which are important for treatment and prognosis.
  • Out of 190 patients, 42.6% showed LA-LVAs, with a higher prevalence in persistent atrial fibrillation cases; the LA-LVAs group had significant differences in age, heart rate, and echocardiographic metrics compared to the non-LVAs group.
  • The findings suggest that automatically assessed left atrial volume index (LAVi) and left atrial reservoir strain (LASr) can effectively
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Submandibular gland (SMG) excision via axillary is a brand new technique and we presented its own unique advantages compared with retroauricular and transoral approaches. The single-port (SP) robotic system offers improved visualization of the view and enhanced flexibility of instruments, ensuring optimal stability and dissection in this surgery. We reported the first case of transaxillary SMG excision using single-port robotic system made in China.

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Hypoglycemia is a common complication which occurs during the treatment of diabetes, closely associated with cardiovascular events. A sudden decrease in blood glucose increases the risk of arrhythmia, which can lead to sudden cardiac death. This event is usually accompanied by abnormal electrophysiological activities in cardiomyocytes.

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  • Oral squamous cell carcinoma (OSCC) is a deadly form of head and neck cancer, with unclear mechanisms behind its development, but studies indicate that saliva from OSCC patients accelerates cancer progression in rat models.
  • Metabolomic analyses show that patients with OSCC have higher levels of kynurenic acid (KYNA) in their saliva and tumor tissues, which is correlated with the presence of Streptococcus mutans bacteria that contribute to KYNA production.
  • The increased KYNA promotes a tumor microenvironment that enhances immune suppression, leading to poorer outcomes in OSCC patients and suggesting that targeting oral microbiota may offer new prevention and treatment strategies for this type of cancer.
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Mycobacterium tuberculosis (Mtb) infection induces a marked influx of neutrophils into the lungs, which intensifies the severity of tuberculosis (TB). The metabolic state of neutrophils significantly influences their functional response during inflammation and interaction with bacterial pathogens. However, the effect of Mtb infection on neutrophil metabolism and its consequent role in TB pathogenesis remain unclear.

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  • Total knee arthroplasty (TKA) is a common surgery for knee osteoarthritis, and the patellar component is crucial for knee function and recovery outcomes.
  • A study analyzed the relationship between various radiological measurements of patellar height and clinical outcomes in 330 TKA patients, revealing significant correlations.
  • Results indicated that specific radiological indices could predict postoperative satisfaction and complications, underscoring their importance in pre-surgical planning and patient evaluations.
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  • - The study estimates the economic and health burden of healthcare-associated infections (HAIs) in New Zealand public hospitals, revealing a 4.74% incidence rate which led to 24,191 HAIs in 2021, resulting in substantial health impacts including 76,861 lost bed days and 699 deaths.
  • - The total economic burden of HAIs in 2021 reached NZ$955 million, broken down into costs for lost bed days (NZ$121 million), years of life lost (NZ$792 million), and Accident Compensation Commission claims (NZ$43 million).
  • - The findings highlight the significant impact of HAIs on patients and the health system, suggesting a need for a strategic plan to implement preventive
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  • The text discusses the importance of using deep learning for semantic segmentation of ultrasound images in medical diagnostics but notes limitations due to the scarcity of data and a focus on single organs.* -
  • To tackle these issues, the authors introduce the Multi-Organ FOundation (MOFO) model, which analyzes multiple organs together, enhancing segmentation by recognizing correlations and utilizing a larger dataset of 7039 images from 10 different organs.* -
  • Results show that the MOFO model outperforms existing single-organ models in key metrics, indicating a significant advancement in ultrasound image segmentation by integrating anatomical insights and improving overall diagnostic accuracy.*
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In this study, NiTi shape memory alloy was prepared by double-wire + arc additive manufacturing plus heat treatment using TA1 and ER-Ni welding wires as the raw materials. The results show that the microstructural evolution from the bottom to top is NiTi + NiTi → NiTi + NiTi + NiTi → NiTi + NiTi + NiTi + NiTi + α-Ti. Complex thermal cycles led to the precipitation of NiTi, which improves the hardness of the matrix (B2), and the average hardness value of the top region reaches 550.

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JOURNAL/nrgr/04.03/01300535-202508000-00027/figure1/v/2024-09-30T120553Z/r/image-tiff Several promising plasma biomarker proteins, such as amyloid-β (Aβ), tau, neurofilament light chain, and glial fibrillary acidic protein, are widely used for the diagnosis of neurodegenerative diseases. However, little is known about the long-term stability of these biomarker proteins in plasma samples stored at -80°C.

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