Clinical and biochemical characteristics, and outcome in 33 patients with ceftriaxone-induced liver injury.

Purpose: To summarize the clinical and biochemical characteristics of patients with ceftriaxone-induced liver injury and guide the selection of safe medication.

Methods: Retrieved domestic and foreign databases from inception to October 2023, collected case data conforming to ceftriaxone-induced liver injury, and statistically analyzed the data.

Results: A total of 617 articles were retrieved, and 16 articles with 33 cases (10 children, 23 adults) were included.

Screening for Wilson's disease in acute liver failure: A new scoring system in children.

Background: Wilson's disease (WD) is a rare cause of acute liver failure (ALF) and has a high fatality rate. Rapid and accurate diagnosis is important for ALF because of WD (ALF-WD). Our objective was to establish a simple, rapid, and accurate diagnostic test to distinguish ALF-WD from non-WD ALF (NWDALF) in children.

Differentially expressed gene profile and relevant pathways of the traditional Chinese medicine cinobufotalin on MCF‑7 breast cancer cells.

Cinobufotalin is a chemical compound extracted from the skin of dried bufo toads that may have curative potential for certain malignancies through different mechanisms; however, these mechanisms remain unexplored in breast cancer. The aim of the present study was to investigate the antitumor mechanism of cinobufotalin in breast cancer by using microarray data and in silico analysis. The microarray data set GSE85871, in which cinobufotalin exerted influences on the MCF‑7 breast cancer cells, was acquired from the Gene Expression Omnibus database, and the differentially expressed genes (DEGs) were analyzed.

Upregulated miR‑203a‑3p and its potential molecular mechanism in breast cancer: A study based on bioinformatics analyses and a comprehensive meta‑analysis.

Breast cancer (BC) has been identified as the leading malignancy in women worldwide. However, the potential molecular mechanism of microRNA (miR)‑203a‑3p in BC remains to be elucidated. The present study evaluated the expression of miR‑203a‑3p in BC and adjacent normal tissue in several publically available datasets.

In vitro-activated tumor-bearing host T cells and the effectiveness of tumor vaccine immunotherapy.

Background And Objective: Vaccination during periods of lymphopenia may facilitate immune responses to weak self-antigens and enhance antitumor immunity. The objective of this study was to determine the effectiveness of tumor vaccine immunotherapy combined with immune reconstruction using tumor-bearing host immune cells in lymphopenia, and to investigate the role of tumor-bearing host T cells activated in vitro during immunotherapy.

Design And Setting: Animal study conducted in the First Affiliated Hospital of Xi'an Jiaotong University from January 2009 to January 2010.

Influences of sodium carbonate on physicochemical properties of lansoprazole in designed multiple coating pellets.

Lansoprazole (LSP), a proton-pump inhibitor, belongs to class II drug. It is especially instable to heat, light, and acidic media, indicating that fabrication of a formulation stabilizing the drug is difficult. The addition of alkaline stabilizer is the most powerful method to protect the drug in solid formulations under detrimental environment.

[Evaluation of immune reconstitution with in vitro-activated T cells from a tumor-bearing host].

Aim: To evaluate the reconstituted immune system with in vitro-activated T cells from tumor-bearing rats coupled with ovarian cancer vaccination.

Methods: Fischer 344 female rats were injected with cyclophosphamide (CY) as a lymphopenia (LP) model. The immune systems of the rats were reconstituted with in vitro-activated T cells from the same individuals.

[Animal experiments of immunotherapy with ovarian tumor vaccine during lymphopenia induced by chemotherapy.].

Objective: To explore the mechanisms and effects of adoptive immunotherapy with ovarian cancer vaccine modified by GM-CSF gene which was used after immunologic reconstitution during lymphopenia induced by chemotherapy.

Methods: Lymphopenia was induced by chemotherapy with cyclophosphamide. The immune reconstituted model was built in rats.

[The clinical observation on acupuncture at Xuanzhong (GB 39) and Ashi points for treatment of orthopedic postoperative pain].

Objective: To compare the therapeutic effects between acupuncture and Bezoxazocine injection in treatment of orthopedic postoperative pain.

Methods: Sixty patients were randomly divided into an acupuncture group and a medication group, 30 cases in each group. The patients in the acupuncture group were treated by acupuncture at Xuanzhong (GB 39) as main point and Ashi points for 30 minutes; the medication group were treated by intramuscular injection of Bezoxazocine injection, 20 mg once, three times per day.