Assembly of Four Ternary Polyoxometalate Aggregates by Integrating Presynthesized {XWNbO} (X = Si/Ge) Units Using Molybdenum-Oxo Clusters.

Polyoxometalates (POMs) have good potential for applications in different fields, including conducting materials, optics, and electrocatalysis. Of particular significance is the synthesis and development of addendum POMs. Molybdenum-oxo clusters, which are renowned for their diverse structures and electronic properties, were utilized to facilitate the synthesis of innovative materials.

Polyoxotungstate Featuring Zinc-Ion-Triggered Structural Transformation as An Efficient Electrolyte Additive for Aqueous Zinc-Ion Batteries.

It is promising but still challenging for the widespread application of aqueous zinc batteries due to the poor reversibility of the zinc anode caused by prevalent dendrite growth and pronounced interfacial side reactions. Herein, we report a rare soluble and water-stable high-nuclearity {NdSiW} polyoxotungstate. Interestingly, upon encountering Zn ions, the discrete {NdSiW} nanocluster undergoes a structural transformation to form an infinitely extended cluster-based {[Zn(HO)][NdSiW]} two-dimensional honeycomb layer, with which atomic-level Zn ion effects in reconstructing the layer are determined.

Thiostrepton: multifaceted biological activities and its applications in treatment of inflammatory diseases.

Thiostrepton (TST) is a naturally occurring oligopeptide antibiotic with a demonstrated capacity to antagonize a broad spectrum of Gram-positive bacteria. It has been utilized as a safe antimicrobial agent in veterinary medicine. Despite its therapeutic potential, the clinical application of TST has been constrained by its poor solubility and bioavailability.

Site differentiation strategy for selective strontium uptake and elution within an all-inorganic polyoxoniobate framework.

Selective uptake and elution of trace amounts of hazardous radioactive Sr from large-scale high-level liquid waste (HLW) is crucial for sustainable development. Here, we propose a site differentiation strategy, based on the presence of distinct selective metal capture sites (concavity site and tweezer site) within the giant polyoxoniobate (PONb) nanoclusters of an all-inorganic PONb framework (FZU-1). Through this strategy, FZU-1 can not only effectively remove 98.

Comprehensive characterization of cytopenia after chimeric antigen receptor-T cell infusion in patients with relapsed or refractory multiple myeloma.

Background: Many studies have demonstrated the effectiveness of chimeric antigen receptor-T (CAR-T) cell therapy for relapsed or refractory multiple myeloma (RRMM), but the hematologic toxicity has not been well characterized.

Methods: A total of 111 adults with RRMM who received BCMA CAR-T cells, BCMA + CD19 CAR-T cells or tandem BCMA/CD19 dual-target (BC19) CAR-T cells infusion were enrolled. We characterized cytopenia and hematologic recovery at different time points after CAR-T-cell therapy, analyzed the effect of cytopenia on prognosis and identified the risk factors.

Indium-Assisted Construction of {SiNbO}-Based Aggregates and Their Assembly into Extended Polyoxoniobate Architectures.

In this research, indium ions were introduced into polyoxoniobates (PONbs) reaction systems to facilitate the construction of different {SiNbO}-based aggregates, including an {In(en){SiNbO}} (en = ethylenediamine) dimer, an {[InO][In(en)O]{SiNbO}} trimer, and an {[In(en)][InO][In(en)O]{SiNbO}} tetramer. Interestingly, these aggregates were further assembled into three uncommon extended PONb architectures in the presence of [Cu(en)] complexes, namely, H[Cu(en)(HO)][Cu(en)][Cu(en)]{[In(en)][K{SiNbO}(HO)]}·1.5en·16HO, H{[Cu(en)]{[Cu(en)][Cu(en)(HO)][In(HO)][In(en)(HO)(OH)]{SiNbO}}·5en·29HO, and H[Cu(en)][Cu(en)(HO)]{[Cu(en)]{[Cu(en)][Cu(en)(HO)][K(HO)][In(HO)][In(en)][In(OH)(en)]{SiNbO}}·7en·39HO.

[Efficacy and Safety of Reduced Dose Azacitidine in the Treatment of Elderly Patients with Myelodysplastic Syndromes].

Objective: To analyze the efficacy and safety of low-dose azacitidine in the treatment of senile myelodysplastic syndromes (MDS).

Methods: A total of 92 elderly MDS patients who were initially diagnosed in the Huaibei Miners General Hospital and the Affiliated Hospital of Xuzhou Medical University from January 2018 to June 2022 were randomly divided into the observation group and the control group with 46 patients in each group. The observation group received a low dose of azacitidine 100 mg/d, d1-7, 28 days as a course of treatment, 6 courses in total, and the control group received a standard dose of azacitidine 75 mg(m·d), d1-7, 28 days as a course of treatment, a total of 6 courses of treatment.

A Palladium-Containing Polyoxotungstate with Anisotropic Proton Conductivity.

Here, a case of bilayer heterojunction Pd-containing polyoxotungstate (POW), connecting a TePd ring and an Anderson-like TeW cluster, has been synthesized. The Anderson-like cluster is the first example in POW. The coordination of Pd in the ring with the S atom on the sulfo group breaks the traditional coordination configuration of Pd and O in polyoxometalates (POMs), enriching the structural types of Pd-containing POMs.

An organophosphate 3d-4f heterometallic polyoxoniobate nanowire.

Four different structural compositions of organophosphate, 3d transition metal, 4f lanthanide and polyoxoniobate (PONb) are unified in a system for the first time to form a new type of organophosphate 3d-4f heterometallic inorganic-organic hybrid PONb nanowire. Interesting magnetic anisotropy and slow magnetic relaxation are found in the PONb nanowire.

Development of Stable Water-Soluble Supratomic Silver Clusters Utilizing A Polyoxoniobate-Protected Strategy: Giant Core-Shell-Type Ag@Nb Fluorescent Nanocluster.

Atomically precise low-nuclearity (n<10) silver nanoclusters (AgNCs) have garnered significant interest due to their size-dependent optical properties and diverse applications. However, their synthesis has remained challenging, primarily due to their inherent instability. The present study introduces a new feasible approach for clustering silver ions utilizing highly negative and redox-inert polyoxoniobates (PONbs) as all-inorganic ligands.

An Organodiphosphate-Containing Polyoxoniobate Ring and Its Assembly into a Three-Dimensional Framework through Hydrogen Bonding.

In this work, a novel organodiphosphate-containing inorganic-organic hybrid polyoxoniobate (PONb) ring {(POCHCHPOH)NbO} () has been achieved by a one-pot hydrothermal method. The ring is constructed from a tetragonal {NbO} motif and four {POCHCHPOH} ligands. Interestingly, can be joined together via K-HO clusters {K(HO)(OH)} to form one-dimensional chains {[K(HO)(OH)]} and further linked by {Cu(en)} (en = ethylenediamine) complexes, resulting in a three-dimensional supramolecular framework {[Cu(en)][K(HO)(OH)]}·3en·HO ().

Complex association of body mass index and outcomes in patients with relapsed and refractory multiple myeloma treated with CAR-T cell immunotherapy.

Background Aims: Chimeric antigen receptor-T (CAR-T) cells have exhibited remarkable efficacy in treating refractory or relapsed multiple myeloma (R/R MM). Although obesity has a favorable value in enhancing the response to immunotherapy, less is known about its predictive value regarding the efficacy and prognosis of CAR-T cell immunotherapy.

Methods: We conducted a retrospective study of 111 patients with R/R MM who underwent CAR-T cell treatment.

Identification of Potential Hub Genes Related to Acute Pancreatitis and Chronic Pancreatitis via Integrated Bioinformatics Analysis and In Vitro Analysis.

Acute pancreatitis (AP) and chronic pancreatitis (CP) are considered to be two separate pancreatic diseases in most studies, but some clinical retrospective analyses in recent years have found some degree of correlation between the two in actual treatment, however, the exact association is not clear. In this study, bioinformatics analysis was utilized to examine microarray sequencing data in mice, with the aim of elucidating the critical signaling pathways and genes involved in the progression from AP to CP. Differential gene expression analyses on murine transcriptomes were conducted using the R programming language and the R/Bioconductor package.

The mechanism governing the formation of intermolecular charge transfer bands: a series of polyoxomolybdates as a case study.

A series of proof-of-concept models of polyoxomolybdates with different protonated disubstituted aniline counterions and the same β-MoO polyanion were synthesized to study the mechanism governing the formation of the intermolecular charge transfer (inter-CT) band.

[Novel CD19-KIRS2/Dap12-BB CAR-T Treatment for 3 Patients with Relapsed and Refractory B-Cell Tumors].

Objective: To investigate the safety and efficacy of novel CD19-KIRS2/Dap12-BB chimeric antigen receptor T cells (CAR-T cells) in the treatment of relapsed/refractory B-cell malignancy (R/R BCM).

Methods: Three patients with R/R BCM treated with novel CD19-KIRS2/Dap12-BB CAR-T cells from June 2020 to November 2020 were enrolled, including 1 case of B-cell acute lymphoblastic leukaemia (B-ALL) and 2 cases of non-Hodgkin's lymphoma (NHL), and the efficacy and adverse reactions were observed.

Results: After CAR-T cells infusion, patient with B-ALL achieved complete remission (CR) and minimal residual disease (MRD) turned negative, and 2 patients with NHL achieved partial remission (PR).

Long-term analysis of cellular immunity in patients with RRMM treated with CAR-T cell therapy.

Chimeric antigen receptor T (CAR-T) cell therapy exhibits remarkable efficacy against refractory or relapsed multiple myeloma (RRMM); however, the immune deficiency following CAR-Ts infusion has not been well studied. In this study, 126 patients who achieved remission post-CAR-Ts infusion were evaluated for cellular immunity. Following lymphodepletion (LD) chemotherapy, the absolute lymphocyte count (ALC) and absolute counts of lymphocyte subsets were significantly lower than baseline at D0.

Comparative analysis of clinicopathologic characteristics and prognosis between nasal and nonnasal extranodal NK/T-cell lymphoma.

Background: The clinicopathologic characteristics and prognosis of nasal and nonnasal extranodal natural killer T-cell lymphoma (ENKTL) are considered to be different. However, the underlying features responsible for these differences are not well clarified especially in the era of asparaginase therapy.

Methods: In total, 1007 newly diagnosed ENKTL patients from 11 medical centers were included in this study.

Photo-Activating Biomimetic Polyoxomolybdate for Boosting Oxygen Evolution in Neutral Electrolytes.

Inspired by the metal-oxo cluster structural feature and charge separation behaviour of the oxygen evolving center (OEC) in photosystem II (PS-II) under photoirradiation, a new crystalline photochromic polyoxomolybdate, MV [β-Mo O ] (1, MV=methyl viologen cation), is designed as a biomimetic oxygen evolution reaction (OER) catalyst in neutral electrolytes. After photoinduced electron transfer (PIET) with colour change from colourless to grey, it remains in an ultra-stable charge-separated state over a year under ambient conditions. The observed overpotential at 10 mA ⋅ cm and Tafel slope decrease by 49 mV and 62.

High-sensitivity fiber optic temperature sensor based on CTFBG-FPI and Vernier effect.

A novel high-sensitivity temperature sensor based on a chirped thin-core fiber Bragg grating Fabry-Perot interferometer (CTFBG-FPI) and the Vernier effect is proposed and demonstrated. With femtosecond laser direct writing technology, two CTFBG-FPIs with different interferometric cavity lengths are inscribed inside a thin-core fiber to form a Vernier effect system. The two FPIs consist of two pairs of CTFBGs with a full width at half maximum (FWHM) of 66.

Revolutionizing SARS-CoV-2 omicron variant detection: Towards faster and more reliable methods.

The emergence of the highly contagious Omicron variant of SARS-CoV-2 has inflicted significant damage during the ongoing COVID-19 pandemic. This new variant's significant sequence changes and mutations in both proteins and RNA have rendered many existing rapid detection methods ineffective in identifying it accurately. As the world races to control the spread of the virus, researchers are urgently exploring new diagnostic strategies to specifically detect Omicron variants with high accuracy and sensitivity.

Reversible Thermochromism and Stable Resistance Switching Behaviors Based on a Co(III)-Complex-Linked Polyoxoniobate.

A 3D Co(III)-complex hybrid polyoxoniobate framework Na(HO)[Co(phen)(4,4'-bipy)(NbO)]·19HO () has been constructed from [Co(phen)(4,4'-bipy)(NbO)] dimer units and 2D inorganic Na-O cluster layers. The Co(III) centers are coordinated with {NbO}, 4,4'-bipy and phen simultaneously. The [Co(phen)(4,4'-bipy)(NbO)] fragments link the Na-O cluster layers to generate a 3D metal complex-modified hybrid polyoxoniobate framework with π-π interactions between phenanthroline rings.

Effects of sources and levels of dietary supplementary manganese on growing yak's rumen fermentation.

Introduction: Manganese (Mn) is an essential trace element for livestock, but little is known about the optimal Mn source and level for yak.

Methods: To improve yak's feeding standards, a 48-h study was designed to examine the effect of supplementary Mn sources including Mn sulfate (MnSO), Mn chloride (MnCl), and Mn methionine (Met-Mn) at five Mn levels, namely 35 mg/kg, 40 mg/kg, 50 mg/kg, 60 mg/kg, and 70 mg/kg dry matter (includes Mn in substrates), on yak's rumen fermentation.

Results: Results showed that Met-Mn groups showed higher acetate ( < 0.