Direct magnetic imaging of fractional Chern insulators in twisted MoTe.

Orbital magnetization provides a sensitive probe of topology and interactions, with particularly rich phenomenology in Chern insulators in which the topological edge states carry large equilibrium currents. Here we use a nanoscale superconducting sensor to map the magnetic fringe fields in twisted bilayers of MoTe, in which transport and optical sensing experiments have revealed the formation of fractional Chern insulator (FCI) states at zero magnetic field. We observe oscillations in the local magnetic field associated with fillings ν = -1, -2/3, -3/5, -4/7 and -5/9 of the first moiré hole band, consistent with the formation of FCIs at these fillings.

Trion sensing of a zero-field composite Fermi liquid.

The half-filled lowest Landau level is a fascinating platform for researching interacting topological phases. A celebrated example is the composite Fermi liquid, a non-Fermi liquid formed by composite fermions in strong magnetic fields. Its zero-field counterpart is predicted in a twisted MoTe bilayer (tMoTe)-a recently discovered fractional Chern insulator exhibiting the fractional quantum anomalous Hall effect.

Assessment of simulated snoring sounds with artificial intelligence for the diagnosis of obstructive sleep apnea.

Background: Performing simulated snoring (SS) is a commonly used method to evaluate the source of snoring in obstructive sleep apnea (OSA). SS sounds is considered as a potential biomarker for OSA. SS sounds can be easily recorded, which is a cost-effective method for prescreening purposes.

Image-based deep learning model to predict stoma-site incisional hernia in patients with temporary ileostomy: A retrospective study.

The prophylactic implantation of biological mesh can effectively prevent the occurrence of stoma-site incisional hernia (SSIH) in patients undergoing stoma retraction. Therefore, our study prospectively established and validated a mixed model, which combined radiomics, stepwise regression, and deep learning for the prediction of SSIH in patients with temporary ileostomy. The mixed model showed good discrimination of the SSIH patients on all cohorts, which outperformed deep learning, radiomics, and clinical models alone (overall area under the curve [AUC]: 0.

Research Progress on the Antifibrotic Activity of Traditional Chinese Medicine Polysaccharides.

Fibrosis is a pathological process characterized by excessive extracellular matrix (ECM) deposition and proliferation fibrous tissue, a condition associated with various chronic diseases, such as liver cirrhosis, inflammation of the lungs, and myocarditis. Clinical treatment options for fibrotic diseases are currently limited and have poor efficacy. However, recent studies have increasingly demonstrated that polysaccharides exhibit significant antifibrotic activity by modulating cell proliferation and migration, inhibiting inflammation and oxidative stress associated fibrosis and regulating gut microbiota.

Selective Inhibition of P2Y and P2Y Receptor Signal Pathways in Platelet Aggregation in Transgenic Cell Lines and Rats by Potassium 2-(1-Hydroxypentyl)-Benzoate, Puerarin and Salvianolic Acid B.

Aim: Potassium 2-(1-hydroxypentyl)-benzoate (dl-PHPB), puerarin and salvianolic acid B are three natural products or derivatives that can inhibit platelet aggregation. However, the mechanisms of dl-PHPB, puerarin and salvianolic acid B to inhibit platelet aggregation are still not clear.

Method: Here, 2-methylthioadenosine diphosphate (2-MeSADP) was used as an inducer to confirm the effects of three drugs on platelet aggregation and illustrate the corresponding mechanisms.

9-Methylfascaplysin Prevents Neuroinflammation and Synaptic Damage via Cell-Specific Inhibition of Kinases in APP/PS1 Transgenic Mice.

Background: Alzheimer's disease (AD) is a leading neurodegenerative disorder without effective treatments. The nonlinear dynamic nature of AD pathophysiology suggested that multiple pharmacological actions of anti-AD drugs should be elucidated. 9-Methylfascaplysin (9-MF) was previously designed and synthesized as a novel anti-AD candidate.

Safety of baricitinib 24 weeks 4 mg or 2 mg for the treatment of rheumatoid arthritis: A meta-analysis of randomized controlled trials.

Backgrounds: Baricitinib, an oral selective inhibitor of Janus kinase 1 and 2, is approved for moderate and severe rheumatoid arthritis (RA) with insufficient response to conventional synthetic disease-modifying antirheumatic drugs. The study evaluated the safety of baricitinib 24 weeks 4 mg or 2 mg for the treatment of RA.

Methods: The net change (least squares mean [LSM]) of alanine aminotransferase (ALT), creatinine, low-density lipoprotein cholesterol (LDL-C) levels from baseline with the comparison of baricitinib versus placebo was pooled, respectively.

Two novel sites determine genetic relationships between CPV-2 and FPV: an epidemiological survey of canine and feline parvoviruses in Changchun, China (2020).

Canine parvovirus (CPV-2) and feline parvovirus (FPV) cause severe hemorrhagic diarrhea disease in dogs, cats, and fur-bearing and wildlife carnivores worldwide, continuing to pose significant threats. In this study, 140 rectal swabs were collected from 70 domestic dogs and 70 cats with clinical diarrhea in veterinary clinics in Changchun during 2020. A total of 64.

Deep learning model for automated diagnosis of moyamoya disease based on magnetic resonance angiography.

Background: This study explores the potential of the deep learning-based convolutional neural network (CNN) to automatically recognize MMD using MRA images from atherosclerotic disease (ASD) and normal control (NC).

Methods: In this retrospective study in China, 600 participants (200 MMD, 200 ASD and 200 NC) were collected from one institution as an internal dataset for training and 60 from another institution were collected as external testing set for validation. All participants were divided into training (N = 450) and validation sets (N = 90), internal testing set (N = 60), and external testing set (N = 60).

Genome wide identification of BjSWEET gene family and drought response analysis of BjSWEET12 and BjSWEET17 genes in Brassica juncea.

Background: Sugars Will Eventually be Exported Transporter (SWEET) gene family is a unique type of sugar transporter that plays a vital role in metabolic regulation, growth, development, and stress response in multiple species. This study aimed to systematically identify the SWEET gene family members and detect the regulation of gene expression and their potential roles of the SWEET gene family in Brassica juncea.

Results: A total of 66 BjSWEET (Brassica juncea Sugar Will Eventually be Exported Transporter) genes distributed across 17 chromosomes were identified.

ACSL5 promotes lipid deposition and lipoapoptosis in proximal tubular epithelial cells of diabetic kidney disease.

Background: Lipoapoptosis in Proximal tubular epithelial cells (PTCs) are substantial in the etiology of diabetic kidney disease (DKD), yet the underlying mechanisms warrant further investigation. Acyl-CoA synthetase long-chain family member 5 (ACSL5) facilitates the formation of acyl-CoA, however, the precise role of ACSL5 in lipoapoptosis of PTCs in DKD remains inconclusive.

Methods: Transcriptomic data analysis identified the hub gene Acsl5 associated with lipid metabolism in DKD.

Dietary Effects of Probiotic Bacteria, AV5 on Growth, Serum and Mucus Immune Response, Metabolomics, and Lipid Metabolism in Nile Tilapia ().

In the present study, we investigated the effect of dietary supplementation with the probiotic AV5 (OR647358) on the growth, serum and mucus immune responses, metabolomics, and lipid metabolism of . Fishes (27.2 ± 1.

Arming oncolytic M1 virus with gasdermin E enhances antitumor efficacy in breast cancer.

Pyroptosis, driven by the N-terminal domain of gasdermin proteins (GSDM), promotes antitumor immunity by attracting lymphocytes to the tumor microenvironment (TME). However, current pyroptosis-inducing therapies like drug injections and phototherapy are limited to localized treatments, making them unsuitable for widespread or microscopic metastatic lesions. This study engineered oncolytic M1 viruses (rM1-mGSDME_FL and rM1-mGSDME_NT) to selectively deliver GSDME to tumor cells.

Development of a streamlined NGS-based TCGA classification scheme for gastric cancer and its implications for personalized therapy.

Background: The Cancer Genome Atlas (TCGA) has identified four distinct molecular subtypes of gastric cancer (GC) with prognostic significance: Epstein-Barr virus (EBV)-positive, microsatellite instability (MSI)-high, genomically stable (GS), and chromosomal instability (CIN). Unfortunately, the complex analysis required for TCGA classification limits its practical use in clinical settings. Our study sought to devise a next-generation sequencing (NGS)-based method to classify GC more efficiently, serving as a promising biomarker for prognosis and immunotherapy efficacy.

Research on the local path planning of an orchard mower based on safe corridor and quadratic programming.

Introduction: Path planning algorithms are challenging to implement with mobile robots in orchards due to kinematic constraints and unstructured environments with narrow and irregularly distributed obstacles.

Methods: To address these challenges and ensure operational safety, a local path planning method for orchard mowers is proposed in this study. This method accounts for the structural characteristics of the mowing operation route and utilizes a path-velocity decoupling method for local planning based on following the global reference operation route, which includes two innovations.

Research on Remote and Near-Field Gas Collaborative Joint Control Technology in Coal and Gas Outburst Coal Seam.

Aiming at the time and space limitation of gas control in the first mining face of newly built outburst mine, this study takes Longfeng Coal Mine in Guizhou as the engineering background and puts forward a concept of far- and near-field gas collaborative joint control based on "orientation + general drilling". The correlation between effective extraction radius and extraction time of No. 9 coal seam is determined by establishing the mathematical model of gas migration in which stress field, diffusion field, and seepage field are coupled.

Disclosure to Whom Matters: Association Between Disclosure of Sexual Orientation and Mental Health Among Chinese LGB People.

Objective: This study aimed to explore the association between disclosure of one's sexual orientation in different social contexts and mental health outcomes among LGB individuals.

Methods: This study used a nationwide sample of 7867 LGB individuals in the mainland of China.

Results: Findings revealed that the disclosure process was associated with positive consequences in several specific contexts such as schools, workplaces, and close friendships, but not in the family context.

Dynamic factor analysis with dependent Gaussian processes for high-dimensional gene expression trajectories.

The increasing availability of high-dimensional, longitudinal measures of gene expression can facilitate understanding of biological mechanisms, as required for precision medicine. Biological knowledge suggests that it may be best to describe complex diseases at the level of underlying pathways, which may interact with one another. We propose a Bayesian approach that allows for characterizing such correlation among different pathways through dependent Gaussian processes (DGP) and mapping the observed high-dimensional gene expression trajectories into unobserved low-dimensional pathway expression trajectories via Bayesian sparse factor analysis.

Multifunctional Polysaccharide Self-Healing Wound Dressing: NIR-Responsive Carboxymethyl Chitosan / Quercetin Hydrogel.

As the misuse of antibiotics increases bacterial resistance, the treatment of infected wounds caused by bacteria encounters significant challenges. Conventional antimicrobial dressings often fall short in their ability to inhibit bacterial infections while simultaneously promoting wound healing. To address this issue, a polysaccharide self-healing hydrogel (CPP@PDA/Que3) wound dressing is successfully developed by incorporating quercetin and polydopamine nanoparticles into a carboxymethyl chitosan matrix.

Constructing Surrogate Lung Ventilation Maps From 4-Dimensional Computed Tomography-Derived Subregional Respiratory Dynamics.

Purpose: To present a 2-stage framework that robustly extracts and maps reliable lung ventilation surrogates based on subregional respiratory dynamics (SRDs) measured from 4-dimensional computed tomography (4DCT) images, with comprehensive consideration of spatial and temporal heterogeneity in the ventilation process over the respiratory cycle.

Methods And Materials: We retrospectively analyzed 3 subject cohorts from the Ventilation and Medical Pulmonary Image Registration Evaluation challenge containing 4DCT and reference ventilation imaging (RefVI) scans. Lung subregions were partitioned on the 4DCT end-of-exhale base phase using anatomically constrained simple linear iterative clustering, whereas sliding-preserved interphase image registrations were performed between the base and other phases.

PTX3 exacerbates hepatocyte pyroptosis in hepatic ischemia-reperfusion injury by promoting macrophage M1 polarization.

Backgrounds: Hepatic ischemia-reperfusion injury (IRI) triggers macrophage activation, which in turn mediates inflammatory responses and affects tissue repair and injury severity. Pentraxin 3 (PTX3) is vital in immune regulation and inflammatory processes. In this study, we aim to investigate the potential role of PTX3 in macrophage-mediated hepatic IRI.