Thermodynamic Bounds on Generalized Transport: From Single-Molecule to Bulk Observables.

We prove that the transport of any differentiable scalar observable in d-dimensional nonequilibrium systems is bounded from above by the total entropy production scaled by the amount the observation "stretches" microscopic coordinates. The result-a time-integrated generalized speed limit-reflects the thermodynamic cost of transport of observables, and places underdamped and overdamped stochastic dynamics on equal footing with deterministic motion. Our work allows for stochastic thermodynamics to make contact with bulk experiments, and fills an important gap in thermodynamic inference, since microscopic dynamics is, at least for short times, underdamped.

Direct Route to Thermodynamic Uncertainty Relations and Their Saturation.

Thermodynamic uncertainty relations (TURs) bound the dissipation in nonequilibrium systems from below by fluctuations of an observed current. Contrasting the elaborate techniques employed in existing proofs, we here prove TURs directly from the Langevin equation. This establishes the TUR as an inherent property of overdamped stochastic equations of motion.

Mathematical, Thermodynamical, and Experimental Necessity for Coarse Graining Empirical Densities and Currents in Continuous Space.

We present general results on fluctuations and spatial correlations of the coarse-grained empirical density and current of Markovian diffusion in equilibrium or nonequilibrium steady states on all timescales. We unravel a deep connection between current fluctuations and generalized time-reversal symmetry, providing new insight into time-averaged observables. We highlight the essential role of coarse graining in space from mathematical, thermodynamical, and experimental points of view.