Aggregation-Induced Electrochemiluminescence of Silica-Confined Tetraphenylethylene with Pd Nanocube-Loaded CoO Nanosheets as a Coreaction Accelerator for Sensitive Bioanalysis.

Aggregation-induced electrochemiluminescence (AIECL) provides a new approach for the development of novel electrochemiluminescence (ECL) strategies. Herein, a biosensor was constructed by incorporating 1,1,2,2-tetra(4-carboxylphenyl)ethylene (HTCPE) into a mesoporous silica nanosphere (MSN) to obtain a highly organized AIECL luminophore of (MSN-HTCPE) for signal antibody (Ab) labeling and using Pd nanocube (NC)-loaded CoO nanosheets (NSs) (PdNCs/CoONSs) as a novel coreaction accelerator. The confinement of HTCPE molecules in the MSN restricted the intramolecular rotation and thus enhanced the radiation transition of HTCPE.

Investigation of 3D Printed Self-Sensing UHPC Composites Using Graphite and Hybrid Carbon Microfibers.

This paper explores the development of 3D-printed self-sensing Ultra-High Performance Concrete (UHPC) by incorporating graphite (G) powder, milled carbon microfiber (MCMF), and chopped carbon microfiber (CCMF) as additives into the UHPC matrix to enhance piezoresistive properties while maintaining workability for 3D printing. Percolation curves were established to identify optimal filler inclusion levels, and a series of compressive tests, including quasi-static cyclic, dynamic cyclic, and monotonic compressive loading, were conducted to evaluate the piezoresistive and mechanical performance of 29 different mix designs. It was found that incorporating G powder improved the conductivity of the UHPC but decreased compressive strength for both mold-cast and 3D-printed specimens.

Local Anesthesia With 1% Lidocaine Versus General Anesthesia for Percutaneous Endoscopic Interlaminar Discectomy at L5/S1 Disc Herniation​​​: A Prospective Randomized Study.

Study Design: A prospective randomized clinical trial.

Objective: In this study, we compared local anesthesia with 1% lidocaine (LA) and general anesthesia (GA) utilized in PEID at L5/S1 disc herniation.

Summary Of Background Data: Given the anatomic characteristics of L5/S1 segment, interlaminar approach was preferred to perform endoscopic discectomy for L5/S1 disc herniation.

Risk factors and prediction model for acute ischemic stroke after off-pump coronary artery bypass grafting based on Bayesian network.

Background: This study aimed to identify the risk factors of acute ischemic stroke (AIS) occurring during hospitalization in patients following off-pump coronary artery bypass grafting (OPCABG) and utilize Bayesian network (BN) methods to establish predictive models for this disease.

Methods: Data were collected from the electronic health records of adult patients who underwent OPCABG at Beijing Anzhen Hospital from January 2018 to December 2022. Patients were allocated to the training and test sets in an 8:2 ratio according to the principle of randomness.

The effect of manipulation under anesthesia on knee kinematics in individuals with arthrofibrosis after anterior cruciate ligament reconstruction.

Background: Manipulation under anesthesia (MUA) has been recommended for refractory arthrofibrosis after anterior cruciate ligament (ACL) reconstruction. However, the effectiveness of MUA to restore normal kinematics of the arthrofibrotic knee is still unclear. The objective of this study was to evaluate tibiofemoral and patellofemoral kinematics in six degrees-of-freedom (6DOF) in patients with arthrofibrosis before and after MUA.

Miniaturized broadband high out-of-band rejection bandpass filter based on spoof surface plasmon polaritons with defected ground structure.

In this paper, a novel compact bandpass filter (BPF) with a wide out-of-band rejection is proposed. It can achieve broadband characteristics by combining hollow bowtie-type spoof surface plasmon polaritons (SSPPs) with complementary H-type defected grounded structures (DGSs) through aperture coupling. Compared with the conventional SSPP unit cells, the hollow bowtie-type structure exhibits much better slow-wave characteristics.

Unlocking Superior Hydrogen Oxidation and CO Poisoning Resistance on Pt Enabled by Tungsten Nitride-Mediated Electronic Modulation.

Enhancing the activity and CO poisoning resistance of Pt-based catalysts for the anodic hydrogen oxidation reaction (HOR) poses a significant challenge in the development of proton exchange membrane fuel cells. Herein, we leverage theoretical calculations to demonstrate that tungsten nitride (WN) can intricately modulate the electronic structure of Pt. This modulation optimizes the hydrogen adsorption, significantly boosting HOR activity, and simultaneously weakens the CO adsorption, markedly improving resistance to CO poisoning.

Effectiveness and Safety of Cefiderocol in Clinical Practice for Treatment of Patients with Gram-Negative Bacterial Infections: US Interim Results of the PROVE Study.

Purpose: The international PROVE retrospective chart-review study aims to assess the real-world effectiveness and safety of cefiderocol for treatment of patients with carbapenem-resistant Gram-negative infections.

Patients And Methods: US centers selected hospitalized patients receiving their first cefiderocol treatment for ≥72 hours for a Gram-negative bacterial infection (November 2020-March 2023). Patient demographics, clinical characteristics, hospitalization, course of infection, antibiotic use, clinical cure (excluding patients with a relapse/reinfection), clinical response at the end of treatment, microbiology, in-hospital all-cause mortality (IH-ACM) at Day 30, and safety were analyzed using descriptive statistics.

Quality and Safety Considerations for Adaptive Radiation Therapy: An ASTRO White Paper.

Purpose: Adaptive radiation therapy (ART) is the latest topic in a series of white papers published by the American Society for Radiation Oncology addressing quality processes and patient safety. ART widens the therapeutic index by improving the precision of radiation dose to targets, allowing for dose escalation and/or minimization of dose to normal tissue. ART is performed via offline or online methods; offline ART is the process of replanning a patient's treatment plan between fractions, whereas online ART involves plan adjustment with the patient on the treatment table.

Mitigating Risks in Cone Beam Computed Tomography Guided Online Adaptive Radiation Therapy: A Preventative Reference Planning Review Approach.

Purpose: Online adaptive radiation therapy (oART) treatment planning requires evaluating the temporal robustness of reference plans and anticipating the potential changes during treatment courses that may even lead to risks unique to the adaptive workflow. This study conducted a risk analysis of the cone beam computed tomography guided adaptive workflow and is the first to assess an adaptive-specific reference planning review that mitigates risk in the planning process to prevent events and treatment deficiencies during adaptation.

Methods And Materials: A quality management team of medical physicists, residents, physicians, and radiation therapists performed a fault tree analysis and failure mode and effects analysis.

The possible anti-tumor actions and mechanisms of active metabolites from Cortex Fraxini.

Cortex Fraxini is a traditional Chinese herb that is widely available, inexpensive, and has low toxicity. Modern pharmacological studies have demonstrated that the active metabolites in Cortex Fraxini, including esculin, esculetin, and fraxetin, exert anti-tumor activities by regulating genes and proteins involved in cancer cell proliferation, apoptosis, invasion, and migration. Additionally, these metabolites play a pivotal role in the regulation of several tumor-associated signaling pathways, including the PI3K/Akt, MAPK/ERK, JAK/STAT3, and Wnt/β-catenin pathways.

Association between cardiometabolic index and congestive heart failure among US adults: a cross-sectional study.

Background: The risk of congestive heart failure (CHF) is significantly affected by obesity. However, data on the association between visceral obesity and the risk of CHF remain limited. We explored the relationship between CHF and cardiometabolic index (CMI).

Long-Term Prognosis and Influencing Factors of Chinese Adolescents With Temporomandibular Disorder After Physical Therapy.

Background: Physical therapy is the preferred conservative treatment for patients with temporomandibular disorder (TMD). However, few studies have investigated the application of physical therapy in adolescents, especially follow-up studies on the long-term prognosis of these patients. This study investigated the short-term effects and long-term prognosis of physical therapy in adolescent patients with TMD and the factors influencing long-term symptoms.

A modified GLIM criteria-based nomogram for the survival prediction of gastric cancer patients undergoing surgical resection.

Background: This study aimed to develop a comprehensive model based on five GLIM variables to predict the individual survival and provide more appropriate patient counseling.

Methods: This retrospective cohort study included 301 gastric cancer (GC) patients undergoing radical resection. C-reactive protein (CRP) as an inflammatory marker was included in GLIM criteria and a nomogram for predicting 5-year overall survival (OS) in GC patients was established.

Screening of identification algorithm for rodent-induced bare patches based on the drone imagery.

Rodent-infested bald spots are crucial indicators of rodent infestation in grasslands. Leveraging Unmanned Aerial Vehicle (UAV) remote sensing technology for discerning detrimental bald spots among plateau pikas has significant implications for assessing associated ecological hazards. Based on UAV-visible light imagery, we classified and recognized the characteristics of plateau pika habitats with five supervised classification algorithms, minimum distance classification (MinD), maximum likelihood classification (ML), support vector machine classification (SVM), Mahalanobis distance classification (MD), and neural network classification (NN) .

Early Oral Feeding is Safe and Comfortable in Patients with Gastric Cancer Undergoing Radical Total Gastrectomy.

Data supporting the safety and clinical efficacy of early oral feeding (EOF) after total gastrectomy are limited. The aim of this prospective randomized controlled study was to explore the safety and clinical efficacy of two early enteral nutrition approaches for gastric cancer patients after radical total gastrectomy. The EOF group had faster postoperative recovery of intestinal function than the enteral tube feeding (ETF) group.

Progressive auto-segmentation for cone-beam computed tomography-based online adaptive radiotherapy.

Background And Purpose: Accurate and automated segmentation of targets and organs-at-risk (OARs) is crucial for the successful clinical application of online adaptive radiotherapy (ART). Current methods for cone-beam computed tomography (CBCT) auto-segmentation face challenges, resulting in segmentations often failing to reach clinical acceptability. Current approaches for CBCT auto-segmentation overlook the wealth of information available from initial planning and prior adaptive fractions that could enhance segmentation precision.

Covalently linked molecular catalysts in conjugated polymer dots boost photocatalytic alcohol oxidation in neutral condition.

As a new class of organic photocatalysts, polymer dots show a potential application in photocatalytic hydrogen peroxide production coupled with chemical oxidation such as methanol oxidation. However, the poor methanol oxidation ability by polymer dots still inhibits the overall photocatalytic reaction occurring in the neutral condition. In this work, an organic molecular catalyst 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl radical is covalently linked to a fluorene unit in a polymer skeleton, eventually enabling photocatalytic hydrogen peroxide production coupled with methanol oxidation in the neutral condition.

Impact of Concurrent Ischaemic Stroke on Unfavourable Outcomes in Men and Women with Dilated Cardiomyopathy.

Background: Growing evidence suggests that concurrent ischaemic stroke (IS) exacerbates the prognosis of patients with dilated cardiomyopathy (DCM) and that this effect may be further influenced by sex. However, the exact effect of sex remains unclear. This study aimed to explore the effects of the relevant risk factors on the prognosis of patients with DCM and concurrent IS.