Publications by authors named "Cahn B"
Acquired ichthyosis is an uncommon dermatologic disorder that presents in adulthood and is often associated with systemic conditions, including malignancies. We report the case of a 38-year-old male patient who developed diffuse scaling characterized by rhomboidal, fish-like scales predominantly affecting the trunk and limb extensors, with sparing of the flexures, palms, and soles. Initial therapeutic interventions with emollients and corticosteroids were unsuccessful.
View Article and Find Full Text PDFBackground: Heart-Smile Training (HST) is an interoceptive compassion-based behavioral intervention that in case reports has been beneficial for depression. Interoception refers to the awareness and regulation of physiological signals from inside the body. Depressed patients often have diminished interoceptive awareness and often experience disconnection from bodily needs and sensations.
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- The FDA regulates medical devices to make sure they are safe and work well before they can be sold.
- A survey was done to understand how the FDA's Medical Devices Advisory Committee makes decisions and what could be improved.
- Out of 92 panel members, most were men and white, and many thought the information from the FDA was fair and that important trials were often designed well.
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- A study was conducted to analyze how often dermatologic surgeons face challenges in identifying the locations of skin cancer tumors before surgery.
- Out of over 17,000 cases, only 0.60% involved uncertain sites, with these cases more common in older, male patients who had biopsies done over a month prior.
- Surgeons commonly used various methods to confirm tumor locations, achieving success in identifying 82% of these uncertain sites, while some surgeries were delayed, especially for non-facial tumors.
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- Smoothened inhibitors (SMOi) are effective for treating basal cell carcinoma but lack guidelines for use in Gorlin syndrome (GS).
- This review aims to evaluate how effective SMOi is for GS, offer practical advice for doctors, and highlight areas needing more research.
- It found that both intermittent and daily dosing of SMOi have similar effectiveness, but intermittent dosing may lead to better patient adherence despite potential side effects.
Therapeutic options for acne scars include subcision and suction with microdermabrasion, but these treatment modalities have not been studied in conjunction. To compare effectiveness of subcision alone versus subcision with suction for the treatment of facial acne scars. Randomized, split-faced, evaluator-blinded control trial.
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- Inconsistent reporting of outcomes in rosacea clinical trials is hindering accurate data analysis and meta-analyses, highlighting the need for standardized outcome measures.
- A core outcome set (COS) was developed through systematic literature reviews and a Delphi process, involving feedback from physicians and patients to identify essential outcomes in rosacea trials.
- The final COS includes 8 key domains, such as skin symptoms and patient satisfaction, which aim to enhance the comparability and relevance of future rosacea research and interventions.
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- Core outcome sets (COSs) for skin diseases are standardized outcomes that should be measured in clinical trials, and the number of COSs is growing globally, highlighting potential overlaps in concepts.
- The study aims to conduct a scoping review to categorize and map all outcomes related to COS initiatives for skin diseases, using databases like PubMed and Embase, and involving stakeholder input.
- The research is funded by the Department of Dermatology at Northwestern University, does not require ethical approval due to the nature of the study, and results will be shared through publications and social media.
Acquired ichthyosis (AI) is a rare, nonhereditary cutaneous disorder that has been associated with numerous neoplastic, infectious, drugs, endocrine, metabolic, autoimmune, and malabsorptive diseases. Review all demographical, clinical, histological, and therapeutic features of AI and focus on all reported associated diseases. We performed a systematic literature review in Pubmed/Medline, Embase, and Cochrane collaboration databases, searching for all articles on AI, with no limits on publication date, participant age, sex or nationality.
View Article and Find Full Text PDFBackground: Previous research has demonstrated that epigenetic changes in specific hypothalamic-pituitary-adrenal (HPA) genes may predict successful psychotherapy in post-traumatic stress disorder (PTSD). A recent Phase 3 clinical trial reported high efficacy of 3,4-methylenedioxymethamphetamine (MDMA)-assisted therapy for treating patients with severe PTSD compared to a therapy with placebo group (NCT03537014). This raises important questions regarding potential mechanisms of MDMA-assisted therapy.
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