Somatic genetic alterations of oncogenes and tumor suppressor genes in cholesteatoma.

Background: Cholesteatoma is a proliferative disease that affects the tympanic cavity and temporal bone. Despite many studies and various theories, the etiopathogenesis of cholesteatoma has not been fully elucidated. Features such as invasion, migration, uncontrolled proliferation, and lack of differentiation are observed in both cholesteatoma and neoplasia.

Analysis of potential protective effects of caffeic acid phenethyl ester against gentamicin ototoxicity: An experimental study.

Objectives: In this study, it is aimed to investigate the potential protective effect of caffeic acid phenethyl ester (CAPE) on ototoxicity caused by gentamicin in a rat model.

Materials And Methods: Thirty Wistar albino rats were divided into 3 groups. Group I was selected as the control group.

Myxoma Arising from the Middle Ear: A Case Report.

The primary head and neck myxomas are rare, generally arising from the mandible, maxilla, and oral cavity. Other anatomical areas, such as cardiac myxomas, may also have metastases to the head and neck regions. The middle ear is an extremely rare location for myxomas.

Inlay Butterfly Cartilage Tympanoplasty: Anatomic and Functional Results.

To evaluate anatomic/functional results of inlay butterfly cartilage tympanoplasty and compare those with the results of over-underlay perichondrium-cartilage island or temporalis fascia tympanoplasties. Patients who operated for primary type 1 tympanoplasty (n = 78) with inlay butterfly cartilage (n = 25), over-underlay perichondrium-cartilage island (n = 36) or over-underlay temporalis fascia (n = 17) graft from January 2005 to January 2015 were included in the study. Age, gender, pre-/postoperative otoscopy findings/audiograms, and follow-up time were obtained from the patient's file.

Endoscopy-Assisted Ear Surgery for Treatment of Chronic Otitis Media With Cholesteatoma, Adhesion, or Retraction Pockets.

The objective of this study was to analyze the results of endoscopy-assisted ear surgery for the treatment of chronic otitis media with cholesteatoma, adhesion, or retraction pockets.Fifty-one patients who underwent oto-endoscopy-assisted canal wall up tympanomastoid surgery and/or limited anterior atticotomy with tympanoplasty for chronic otitis media with cholesteatoma, adhesion, or retraction pocket from 2006 to 2013 have been included in this study. Eradication of the disease from the middle ear and mastoid air cells was achieved by combination of the oto-microscobic and oto-endoscopic approaches.

The Audiometric and Mechanical Effects of Partial Ossicular Discontinuity.

Objectives: Ossicular discontinuity may be complete, with no contact between the disconnected ends, or partial, where normal contact at an ossicular joint or along a continuous bony segment of an ossicle is replaced by soft tissue or simply by contact of opposing bones. Complete ossicular discontinuity typically results in an audiometric pattern of a large, flat conductive hearing loss. In contrast, in cases where otomicroscopy reveals a normal external ear canal and tympanic membrane, high-frequency conductive hearing loss has been proposed as an indicator of partial ossicular discontinuity.

Dermoid Cyst Arising from the Epiglottis.

Dermoid cysts arising from the head and neck region are rare, slow-growing, and well-circumscribed neoplasms. Symptoms are non-specific and usually related to the size and the location of the lesion. A dermoid cyst of the epiglottis is extremely rare.

Power reflectance as a screening tool for the diagnosis of superior semicircular canal dehiscence.

Hypothesis: Power reflectance (PR) measurements in ears with superior canal dehiscence (SCD) have a characteristic pattern, the detection of which can assist in diagnosis.

Background: The aim of this study was to determine whether PR coupled with a novel detection algorithm can perform well as a fast, noninvasive, and easy screening test for SCD. The screening test aimed to determine whether patients with various vestibular and/or auditory symptom(s) should be further considered for more expensive and invasive tests that better define the diagnosis of SCD (and other third-window lesions).

[Effect of radiofrequency thermal ablation treatment on nasal mucociliary clearance in patients with isolated inferior turbinate hypertrophy].

Objectives: This study aims to evaluate the effect of the radiofrequency thermal ablation on nasal mucociliary clearance in patients with isolated inferior concha hypertrophy.

Patients And Methods: Thirty patients (10 females, 20 males; mean age 31.0±12.

Comparisons of the mechanics of partial and total ossicular replacement prostheses with cartilage in a cadaveric temporal bone preparation.

Conclusions: Reconstruction of the ossicular chain differentially affects the motion of the tympanic membrane (TM) and the stapes.

Objectives: To determine the effect of different ossicular replacement procedures on the sound-induced motion of the TM and stapes.

Methods: A combination of digital stroboscopic holography and laser Doppler vibrometry was used to determine the sound-induced motion of the TM and stapes in cadaveric temporal bones in which the ossicular chain was reconstructed using 12 varied standard techniques.

[Lingual schwannoma].

Schwannomas are benign, slow growing, solitary and encapsulated neuroectodermal tumors arising from Schwann cells of the nerve sheath. Twenty-five percent of all extracranial schwannomas are seen in the head and neck region. Intra-oral schwannomas are rare and commonly seen at the tongue base.

[Evaluation of efficacy of radiofrequency thermal ablation technique by computed tomography and visual analog scale in treatment of isolated inferior turbinate hypertrophy].

Objectives: This study aims to evaluate the efficacy of radiofrequency thermal ablation (RFTA) technique by computed tomography (CT) and visual analog scale (VAS) in patients with isolated inferior turbinate hypertrophy.

Patients And Methods: Between May 2009 and December 2009, 30 patients (10 females, 20 males; mean age 31.0±12.

Distal superficial temporal artery to proximal posterior cerebral artery bypass by posterior oblique transzygomatic subtemporal approach.

This article investigates the possibility for the distal superficial temporal artery (STA) to proximal posterior cerebral artery (PCA) direct bypass by subtemporal oblique posterior transzygomatic approach. Five adult cadaveric specimens were dissected. Cadeveric dissection protocol was approved by the Research Ethics Committee.

[Isolated stapedius tendon ossification: a case report].

In this study, a case with bilateral isolated stapedius tendon ossification was reported, since it is a rare clinical condition. A 46-year-old female patient was admitted to our clinic with the complaint of bilateral hearing loss. Tympanic membrane was bilateral normal in color and appearance on otomicroscopic examination.

Cartilage tympanoplasty with island technique for reconstruction of tympanic membrane perforation: anatomic and audiologic results.

Objectives: The aim of this study was to evaluate anatomic/audiologic outcomes of cartilage tympanoplasty with island technique and compare the results with the results of temporalis fascia tympanoplasty.

Patients And Methods: The charts of 40 patients who underwent surgery for primary type 1 tympanoplasty either with perichondrium-cartilage (12 males, 11 females; mean age 29.7 years; range 12 to 58 years) or fascia graft (9 males, 8 females; mean age 32.

[Temporal bone transverse fracture and peripheric facial paralysis: our surgical approach and results].

Objectives: In this study, our surgical approaches in temporal bone transvers fracture cases with facial paralysis and their results were evaluated.

Patients And Methods: Five temporal bone transverse fracture cases (2 females, 3 males; mean age 32.8 years; range 4 to 62 years) with facial paralysis which were treated in our clinic between July 1998 and July 2008 were included in this study.

[Approach to the primary mass and neck in lower lip cancers: analysis of 24 cases].

Objectives: In this study, we analyzed the surgical approach which we carried out for treatment of the primary mass and neck in 24 lower lip cancer cases and its results.

Patients And Methods: 24 patients (5 females, 19 males; mean age 56.8; range 41 to 72 years) who were operated on in our clinic for lip cancer between March 1995 and March 2007 and whom we were able to long term follow-up were included in this study.

Proximal STA to proximal PCA bypass using a radial artery graft by posterior oblique transzygomatic subtemporal approach.

The aim of the present study was to investigate the use of a radial artery graft (RAG) for bypass of the proximal superficial temporal artery (STA) to proximal posterior cerebral artery (PCA) by posterior oblique transzygomatic subtemporal approach as an alternative to the external carotid artery (ECA) to PCA anastomosis. We conducted an anatomical and technical study at a university hospital. Five adult cadaveric specimens were dissected.

[Petrous bone lesions].

Objectives: We evaluated the results of treatment and follow-up of patients with petrous bone lesions.

Patients And Methods: We retrospectively evaluated 13 patients (5 females, 8 males; mean age 33.8+/-17.

Transzygomatic-Subtemporal Approach for Middle Meningeal-to-P2 Segment of the Posterior Cerebral Artery Bypass: An Anatomical and Technical Study.

We evaluated the use of a bypass between the middle meningeal artery (MMA) and P2 segment of the posterior cerebral artery (PCA) as an alternative to an external carotid artery (ECA-to-PCA) anastomosis. Five adult cadaveric heads (10 sides) were used. After a temporal craniotomy and zygomatic arch osteotomy were performed, the dura of the floor of the middle cranial fossa was separated and elevated.

Anterior atticoantrostomy for cholesteatoma surgery.

Objectives: We aimed to investigate the long-term results of anterior atticoantrostomy in adult patients with cholesteatoma.

Methods: A total of 83 ears in 78 patients were operated on by the anterior atticoantrostomy technique, supported by a periosteal flap, between 1991 and 2002.

Results: Cholesteatoma recurred in only 4 ears (4.

A modified technique to bypass the maxillary artery to supraclinoid internal carotid artery by using radial artery graft: an anatomical study.

Objective: This study aims to examine the use of a radial artery graft for bypass of the maxillary artery (MA) to the supraclinoid internal carotid artery (ICA) in treating ICA occlusions.

Study Design And Setting: This method was carried out on five adult cadaver sides. The MA was reached 1-2 cm inferior to the crista infratemporalis, following a frontotemporal craniotomy and a zygomatic arch osteotomy.

Parapharyngeal lipoma extending to skull base: a case report and review of the literature.

Lipomas in the head and neck region usually occur in the immediate subcutaneous tissue. They are extremely rare in the parapharyngeal space. A rare case of a right parapharyngeal space lipoma extending to skull base in an 18-year-old male is reported.

Iatrogenic epidermal inclusion cyst of the parapharyngeal space: unusual complication of ear surgery.

A 46-year-old man presented with a 12-month history of a slow-growing mass at the right anterior temporal and superior parotid region. He had a history of chronic otitis media and had undergone a modified radical mastoidectomy for cholesteatoma 5 years earlier. Physical examination revealed a sinus tract and diffuse soft tissue mass measuring 4 cm in diameter spread throughout the region of the right anterior temporal and superior parotid areas.