Publications by authors named "Caecilia Koestler"
Article Synopsis
- The fungal type I fatty acid synthase (FAS) is a large enzyme complex responsible for creating long acyl chains, with a key modification required for its activation.
- An important enzyme, phosphopantetheine transferase (PPT), modifies the acyl carrier domain (ACP) but is physically separated in the FAS structure, suggesting that activation must occur before the complex fully assembles.
- The study focuses on understanding the activation process and assembly pathway of FAS by examining the structure and function of the PPT in the yeast Saccharomyces cerevisiae, both as part of the larger complex and on its own.
