Publications by authors named "Cade E Sterling"
The murine hepatitis virus (MHV) is an important model system for studying coronavirus (CoV) molecular and cell biology. Despite this, few reagents for MHV are available through repositories such as ATCC or Addgene, potentially limiting the widespread adoption of MHV as a tractable model system. To overcome some challenges inherent in the existing MHV reverse genetics systems, we developed a plasmid-launched transformation-associated recombination (TAR) cloning-based system to assemble the MHV (strain A59; MHV-A59) genome.
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- Jamestown Canyon virus (JCV) is a type of bunyavirus that causes neuroinvasive diseases in the U.S., but its mechanism of infection is not well understood.
- Recent research identifies low-density lipoprotein receptor related protein 1 (Lrp1) as a key factor that enables JCV and other bunyaviruses to infect cells, particularly in the nervous system.
- Experiments show that neurons lacking Lrp1 have reduced JCV infection rates, suggesting that targeting Lrp1 could lead to new antiviral treatments for diseases caused by bunyaviruses.