[Cervical cystic lymph-node metastases from epidermoid carcinoma].

Fifty-three cases of cystic nodal neck metastasis from squamous cell carcinoma were treated at the Institut Gustave Roussy over a 30 year period. In all cases the lesion presented as a cystic neck tumor with malignant cells found in the cyst wall on pathologic examination. A detailed physical examination of the upper aerodigestive tract mucosa revealed a small tumor located in Waldeyer's ring and often in the tonsil.

Prognostic value of EBV markers in the clinical management of nasopharyngeal carcinoma (NPC): a multicenter follow-up study.

Between December 1979 and April 1982, 373 patients with untreated, undifferentiated carcinoma of the nasopharynx (NPC), 99 in Hong Kong, 120 in Tunis and 154 in Villejuif, entered a longitudinal study aimed at determining the clinical prognostic value of EBV serology after radiotherapy. A minimum of 3 years' follow-up was achieved for 319 patients (83 in Tunis, 95 in Hong Kong and 141 in Villejuif) who had regular clinical and serological testing at intervals of 6-8 months. No significant difference in initial serology (i.

Ten-year results of randomized trial comparing radiotherapy and concomitant bleomycin to radiotherapy alone in epidermoid carcinomas of the oropharynx: experience of the European Organization for Research and Treatment of Cancer.

This trial of treatment for head and neck carcinoma was initiated in 1973 by the European Organization for Research and Treatment of Cancer. Its purpose was to investigate the value of single-agent chemotherapy with bleomycin (BLM) given during the course of a conventional treatment by external radiotherapy (RT) compared to treatment by external RT alone. In this randomized study, we compared treatment results in 2 groups of patients with squamous cell carcinoma of the oropharynx (T2, T3, and T4; International Union Against Cancer classification).

Prognostic factors in cervical lymph node metastasis in upper respiratory and digestive tract carcinomas: study of 1,713 cases during a 15-year period.

A prospective study of 1,713 patients with squamous cell carcinoma of the head and neck submitted to neck dissection between 1957 and 1973 is presented. We confirm the prognostic significance of the histological analysis of the nodal metastasis. Capsular rupture is the most important factor regardless of the primary site or tumor size.

[Ligation of the common carotid. Studies of the circumstances and follow up of 42 ligations].

The authors report the results of a series, between 1969 and 1978, of 42 patients who had received ligation to the carotid arterial trunk. In 36 patients, the ligation was performed as an emergency measure, often under extemporary circumstances, because of massive hemorrhage in individuals who had received surgery after previous radiotherapy. The complications after applying these ligatures have been catastrophic for many reasons.

HLA-A, -B, and -DR antigens in North African patients with nasopharyngeal carcinoma.

Seventy-six North African patients (most from Algeria) affected with nasopharyngeal carcinoma (NPC) have been studied for their HLA-A, -B, and -DR phenotypes and compared with a control North African population. Antigens HLA-A3, HLA-B5 and HLA-Bw15 were found more frequently in the NPC group than in the control group (30.3% vs 17.

The value of combining radiotherapy with surgery in the treatment of hypopharyngeal and laryngeal cancers.

Two-hundred and six cases of hypopharyngeal and laryngeal squamous cell carcinoma treated at the Institut Gustave-Roussy were retrospectively analyzed. All of them were treated by surgery and they were divided into three therapeutic groups following the adjuvant radiotherapy: (A) Postoperative radiotherapy at doses equal to or greater than 4500 rad; (B) Postoperative radiotherapy at doses less than 4500 rad; and (C) Preoperative irradiation at doses less than 4500 rad. Group A included a greater proportion of patients with hypopharyngeal cancer and patients with advanced tumors (T3, T4; N1b, N2, N3).

Lymphoid cells in lymph nodes and peripheral blood of patients with squamous cell carcinoma of the head and neck.

Fifty-five patients with squamous cell carcinoma of the head and neck were evaluated immunologically by measuring the level of T cells (E-RFC) and high affinity subset T cells (E-29) in the peripheral blood and peritumorous lymph nodes. A significant decrease (p less than 0.05) in mean percentage of E-29 was observed in cancer patient peripheral blood.

[Combination of radiotherapy and chemotherapy in the treatment of upper respiratory and digestive tract carcinomas (author's transl)].

The authors set out in detail the conditions for which adjuvant chemotherapy is used in the treatment of carcinomas of the upper respiratory and digestive tracts. The conditions are at the same time of a theoretical (natural history as shown by cell kinetics) and of a practical (general physical state) nature. They evaluate 34 randomised therapeutic trials and 14 phase II trials: chemotherapy given either before, during or after radiotherapy.

[Muco-epidermoid carcinoma of the mandible. A case report (author's transl)].

Muco-epidermoid tumours are reviewed, and a case of a muco-epidermoid carcinoma of the mandible in a 78-year-old man reported. Radiological examination suggested the presence of an ameloblastoma, but the scanner provided evidence of a possible malignant tumour. Diagnosis of a muco-epidermoid carcinoma was confirmed by pathological examination after hemimandibulectomy.

Elective versus therapeutic radical neck dissection in epidermoid carcinoma of the oral cavity: results of a randomized clinical trial.

This study concerns 75 patients with squamous cell carcinoma of the oral cavity who were patients at the Gustave-Roussy Institute between December 1966 and July 1973. These patients were divided into two groups. The first group was comprised of 39 patients who underwent elective radical neck dissection; nodal involvement was present in 49% with capsular rupture in 13%.

[Tuberculosis of the mucosa of the naso-pharynx. A clinical study of 37 cases seen at the Gustave-Roussy Institute between 1961 and 1978 (author's transl)].

The authors report a series of 37 cases presenting with tuberculosis of the mucosa of the upper naso-pharynx. The localization broke down as: 5 cases of tuberculosis of naso-sinuses, 6 of the buccal cavity, 3 of the cavum, 10 of the oro-pharynx, 1 of the hypopharynx, and 12 of the larynx. -- The male-female ratio was unequal (2:1 M:F) -- The mean age was 52.

[Carcinomas of the nasopharynx. Relationship between histological type and anti-Epstein-Barr virus serology (author's transl)].

This study was aimed at the comparison of values of anti-Epstein-Barr virus serology in different groups of patients suffering from carcinoma of the nasopharynx (NPC), classified according to histological type defined by the new classification of the WHO. A group of patients with other tumours of the upper respiratory and digestive tract was used as a control. Antibody levels were high in patients with undifferentiated carcinomas whilst they were low in the controls.

[Intra-arterial chemotherapy for the treatment of tumors of the nasal sinuses. Results in 50 cases (author's transl)].

Fifty patients with primary epidermoid carcinomas of the nasal sinuses were treated by intra-arterial chemotherapy, alone (2 fatal iatrogenic accidents occurred) or in association with surgery and/or radiotherapy (48 cases). Adverse reactions due to chemotherapy were noted in 11 patients (22%), and two of these were fatal (4%). In eleven patients (22%) the initial curative chemotherapy was unsuccessful and all died after a mean survival period of 12 months.

Lymphoepitheliomas of the larynx (undifferentiated carcinomas of nasopharyngeal type).

Three cases of lymphoepitheliomas of the larynx are reported. This type of carcinoma--which occurs almost exclusively in nasopharynx--is very unfrequent in the larynx (0.2%).

[Surgical treatment of orostoma after oral cavity irradiation (author's transl)].

Surgery treatment of orostoma raises the problem of when operation is indicated and more particularly at what period it should be performed. The imperatives defined have to be respected, and a distant flap, such as a deltopectoral flap, has to used immediately in order to hope for the best results, though the possibility of a recurrence has to be kept in mind.