Efficacy of treatment options for complicated urinary tract infections including acute pyelonephritis: a systematic literature review and network meta-analysis.

Compared with uncomplicated urinary tract infections (UTIs), complicated UTIs (cUTIs) including acute pyelonephritis (AP) present with significant morbidity, a higher risk of treatment failure and typically require longer courses of treatment, or alternative antibiotics. The emergence of drug-resistant organisms represents a considerable challenge in the treatment of patients with cUTIs/AP and has limited antibiotic options. Carbapenems are considered the current last line of therapy, however, carbapenem resistance represents a growing problem.

Pomegranate supplementation alleviates dyslipidemia and the onset of non-alcoholic fatty liver disease in Wistar rats by shifting microbiota and producing urolithin-like microbial metabolites.

Non-alcoholic fatty liver disease (NAFLD), obesity and related chronic diseases are major non-communicable diseases with high mortality rates worldwide. While dietary sugars are known to be responsible for insulin resistance and metabolic syndrome (MetS), the underlying pathophysiological effects of sustained fructose consumption require further elucidation. We hypothesize that certain bioactive compounds ( punicalagin and ellagic acid) from dietary pomegranate could counteract the harmful effects of sustained fructose consumption in terms of obesity and liver damage.

Case report: Fatal lung hyperinflammation in a preterm newborn with SARS-CoV-2 infection.

Vertical transmission of SARS-CoV-2 from mother to fetus is widely accepted. Whereas most infected neonates present with mild symptoms or are asymptomatic, respiratory distress syndrome (RDS) and abnormal lung images are significantly more frequent in COVID-19 positive neonates than in non-infected newborns. Fatality is rare and discordant meta-analyses of case reports and series relating perinatal maternal COVID-19 status to neonatal disease severity complicate their extrapolation as prognostic indicators.

Biodegradation of Punicalagin into Ellagic Acid by Selected Probiotic Bacteria: A Study of the Underlying Mechanisms by MS-Based Proteomics.

Pomegranate ( L.) is a well-known source of bioactive phenolic compounds such as ellagitannins, anthocyanins, and flavanols. Punicalagin, one of the main constituents of pomegranate, needs to be biodegraded by bacteria to yield metabolites of medicinal interest.

[Lymphocyte-to-C-reactive protein ratio in COVID-19: an unexplored tool].

Background: COVID-19 develops severe inflammatory responses that can lead to death. It is essential in a pandemic to have accessible instruments to estimate the prognosis of the disease. The lymphocyte-to-C-reactive protein ratio (LCR) is a predictive biomarker studied in oncology, which could have some advantages in COVID-19 patients in the early stages of the disease.

A global search for novel transcription factors impacting the Neurospora crassa circadian clock.

Eukaryotic circadian oscillators share a common circuit architecture, a negative feedback loop in which a positive element activates the transcription of a negative one that then represses the action of the former, inhibiting its own expression. While studies in mammals and insects have revealed additional transcriptional inputs modulating the expression of core clock components, this has been less characterized in the model Neurospora crassa, where the participation of other transcriptional components impacting circadian clock dynamics remains rather unexplored. Thus, we sought to identify additional transcriptional regulators modulating the N.

A Heuristic to Create Prosumer Community Groups in the Social Internet of Energy.

Contrary to the rapid evolution experienced in the last decade of Information and Communication Technologies and particularly the Internet of Things, electric power distribution systems have remained exceptionally steady for a long time. Energy users are no longer passive actors; the prosumer is expected to be the primary agent in the Future Grid. Demand Side Management refers to the management of energy production and consumption at the demand side, and there seems to be an increasing concern about the scalability of Demand Side Management services.

Diet Quality, Obesity and Breast Cancer Risk: An Epidemiologic Study in Córdoba, Argentina.

Breast cancer (BC) is a multifactorial disease. Environmental factors, specifically, obesity and diet quality, have been linked with an increased risk of BC in women. This research was aimed at assessing the association of diet quality with BC risk, considering nutritional status, in Córdoba province (Argentina).

Ontology-Defined Middleware for Internet of Things Architectures.

The Internet of Things scenario is composed of an amalgamation of physical devices. Those physical devices are heterogeneous in their nature both in terms of communication protocols and in data exchange formats. The Web of Things emerged as a homogenization layer that uses well-established web technologies and semantic web technologies to exchange data.

Epidemiology of uterine myomas and clinical practice in Spain: An observational study.

Objective: Characterization of the clinical features of symptomatic uterine myomas in Spanish women visiting the gynaecologist, including impact on quality of life and possible risk factors, description of main therapeutic approaches, and evaluation of symptom and quality of life progression 6 months after inclusion in the study.

Study Design: This was an observational, epidemiological, non-interventional, multicentre study performed between June 2015 and March 2016. Data were collected at baseline and follow-up visits 6 months apart from women with a diagnosis of uterine myomas and visiting a participating gynaecologist in outpatient units of private clinics or public hospitals in Spain.

Risk of drug-related falls among noninstitutionalized older adults.

Objective: To determine the number of drugs taken per day, which represents a risk factor for falls among noninstitutionalized older adults with a history of falls in the last year.

Method: This was a descriptive study that used random sampling and the following measurement instruments: the WHO questionnaire for the study of falls in older adults, gait scale and geriatric depression scale and gait and balance. Univariate and bivariate analysis, nonparametric chi-squared test, and binary logistic regression were performed using the SPSS statistical program version 21.

Prototyping a Web-of-Energy Architecture for Smart Integration of Sensor Networks in Smart Grids Domain.

Sensor networks and the Internet of Things have driven the evolution of traditional electric power distribution networks towards a new paradigm referred to as Smart Grid. However, the different elements that compose the Information and Communication Technologies (ICTs) layer of a Smart Grid are usually conceived as isolated systems that typically result in rigid hardware architectures which are hard to interoperate, manage, and to adapt to new situations. If the Smart Grid paradigm has to be presented as a solution to the demand for distributed and intelligent energy management system, it is necessary to deploy innovative IT infrastructures to support these smart functions.

Dosimetry of Tc (DTPA, DMSA and MAG3) used in renal function studies of newborns and children.

The dose to kidneys of newborns and 1-year old children was calculated using the MIRD methodology. In order to perform renal studies radiopharmaceutical like Tc-DTPA, Tc-MAG3 and Tc-DMSA are used. Here, besides the anatomic and structure information of kidneys another data are provided in benefit of patient, however during the radioisotope decay emitted radiations delivers, totally or partially, their energy.

Observational analysis of the offensive sequences that ended in a shot by the winning team of the 2010 UEFA Futsal Championship.

This article analyses the offensive phase of the national team than won the 2010 UEFA Championship. More specifically, the observational sampling includes all plays in which the Spanish national futsal team managed to "shoot" in the competition in question. This data was obtained by adapting an observational and recording tool typically used for football to the technical specifications of futsal; the SOF-CODER (Jonsson et al.

Expression of Shigella flexneri gluQ-rs gene is linked to dksA and controlled by a transcriptional terminator.

Background: Glutamyl queuosine-tRNA(Asp) synthetase (GluQ-RS) is a paralog of the catalytic domain of glutamyl-tRNA synthetase and catalyzes the formation of glutamyl-queuosine on the wobble position of tRNA(Asp). Here we analyze the transcription of its gene in Shigella flexneri, where it is found downstream of dksA, which encodes a transcriptional regulator involved in stress responses.

Results: The genomic organization, dksA-gluQ-rs, is conserved in more than 40 bacterial species.

New biofuel integrating glycerol into its composition through the use of covalent immobilized pig pancreatic lipase.

By using 1,3-specific Pig Pancreatic lipase (EC 3.1.1.

Contribution of "modified genetic sonography" to the combined test as a screening method for chromosomal abnormalities.

Objectives: We propose to assess the contribution of "modified genetic sonography" (MGS) to the combined test (CT) as a method of stepwise sequential screening (1st step: CT, 2nd step: MGS) for chromosome abnormalities in the general population of pregnant women.

Methods: Prospective study. During a 4 year study period (July 2005-June 2009) 16,548 pregnancies underwent a CT combined with MGS (major malformation and nuchal fold) as a screening method for chromosome abnormalities.

Oxidative stress in mouse liver caused by dietary amino acid deprivation: protective effect of methionine.

The aim of this work was to evaluate the effects of a diet depleted of amino acids (protein-free diet, or PFD), as well as the supplementation with methionine (PFD+Met), on the antioxidant status of the female mouse liver. With this purpose, cytosolic protein spots from two-dimensional non-equilibrium pH gel electrophoresis were identified by several procedures, such as mass spectrometry, Western blot, gel matching and enzymatic activity. PFD decreased the contents of catalase (CAT), peroxiredoxin I (Prx-I), and glutathione peroxidase (GPx) by 67%, 37% and 45%, respectively.

Plasma and tissue depletion of florfenicol and florfenicol-amine in chickens.

Chickens were used to investigate plasma disposition of florfenicol after single intravenous (i.v.) and oral dose (20 mg kg-1 body weight) and to study residue depletion of florfenicol and its major metabolite florfenicol-amine after multiple oral doses (40 mg kg-1 body weight, daily for 3 days).

Preliminary molecular genetic analysis of the Receptor Interacting Protein 140 (RIP140) in women affected by endometriosis.

Background: Endometriosis is a complex disease affecting 10-15% of women at reproductive age. Very few genes are known to be altered in this pathology. RIP140 protein is an important cofactor of oestrogen receptor and many other nuclear receptors.