Biotechnological Fungal Platforms for the Production of Biosynthetic Cannabinoids.

Cannabinoids are bioactive meroterpenoids comprising prenylated polyketide molecules that can modulate a wide range of physiological processes. Cannabinoids have been shown to possess various medical/therapeutic effects, such as anti-convulsive, anti-anxiety, anti-psychotic, antinausea, and anti-microbial properties. The increasing interest in their beneficial effects and application as clinically useful drugs has promoted the development of heterologous biosynthetic platforms for the industrial production of these compounds.

[Delayed administration of thrombolytic therapy in minor stroke].

Introduction: Minor strokes are considered to be those that present with few symptoms, although up to 40% of them entail long-term disability. The rate of thrombolysis in these patients is also lower than in other strokes. The aim of this study is to explore whether there are any differences in intravenous thrombolysis care times in minor strokes.

Penicillium chrysogenum Fermentation and Analysis of Benzylpenicillin by Bioassay and HPLC.

Penicillium chrysogenum, recently re-identified as Penicillium rubens, is the microorganism used for the industrial production of penicillin. This filamentous fungus (mold) probably represents the best example of adaptation of a microorganism to industrial production conditions and therefore, it can be considered as a model organism for the study of primary and secondary metabolism under a highly stressful environment. In this regard, biosynthesis and production of benzylpenicillin can be used as an interesting phenotypic trait for those studies.

Pandemic and Typhoon: Positive Impacts of a Double Disaster on Mental Health of Female Students in the Philippines.

Humanitarian emergencies pose a great challenge to how all sectors perform their functions in society. In several countries, these emergencies combined the pandemic and other man-made and natural disasters: "double disaster", which affected the health, safety, and well-being of both individuals and communities. Students are a particularly vulnerable population for mental health problems considering the challenges with their transitions to adulthood.

Tobacco cessation in low- to middle-income countries: A scoping review of randomized controlled trials.

Objective: The growing prevalence of tobacco use in low "to middle" income countries (LMICs) and the hurdles of conducting tobacco cessation in that context necessitates a focus on the scope of randomized controlled trials (RCTs) in LMICs to guide tobacco cessation in this environment. We conducted a scoping review to identify LMIC tobacco cessation RCTs.

Methods: Consistent with PRISMA-ScR guidelines and without language restrictions, we systematically searched peer-reviewed databases (MEDLINE, Embase, PsycINFO, articles published since inception, latest searches in March 2020) and gray literature (clinical trials registries, searches between September and December 2019).

Auxins of microbial origin and their use in agriculture.

To maintain the world population demand, a sustainable agriculture is needed. Since current global vision is more friendly with the environment, eco-friendly alternatives are desirable. In this sense, plant growth-promoting rhizobacteria could be the choice for the management of soil-borne diseases of crop plants.

Omics Approaches Applied to and Penicillin Production: Revealing the Secrets of Improved Productivity.

Penicillin biosynthesis by is one of the best-characterized biological processes from the genetic, molecular, biochemical, and subcellular points of view. Several omics studies have been carried out in this filamentous fungus during the last decade, which have contributed to gathering a deep knowledge about the molecular mechanisms underlying improved productivity in industrial strains. The information provided by these studies is extremely useful for enhancing the production of penicillin or other bioactive secondary metabolites by means of Biotechnology or Synthetic Biology.

The scope of tobacco cessation randomized controlled trials in low- to middle-income countries: protocol for a scoping review.

Background: Tobacco consumption is the leading cause of preventable death globally. The global mortality burden of tobacco use lies predominantly in low- to middle-income countries (LMICs). There is much evidence on the effectiveness of tobacco cessation RCTs in high-income nations.

Cervical dissection diagnoses increase following endovascular treatments.

Objectives: The detection of cervical arterial dissection (CAD) has been rising in recent years owing to advanced imaging techniques. The aim of this study was to explore whether wide implementation of endovascular treatment for ischemic stroke has an impact on the diagnosis of CAD.

Methods: We included all patients with CAD diagnosed at two university hospitals in Seville, Spain from January 2015 to December 2017.

Mitochondria in Sepsis-Induced AKI.

AKI is a common clinical condition associated with the risk of developing CKD and ESKD. Sepsis is the leading cause of AKI in the intensive care unit (ICU) and accounts for nearly half of all AKI events. Patients with AKI who require dialysis have an unacceptably high mortality rate of 60%-80%.

Phosphorus recovery by ion exchange in a solid carbonate: modeling of the process.

Phosphorus (P) is a nutrient for plant growth but also a pollutant in water bodies causing eutrophication. The source of P is mainly human and animal wastewater and runoffs from different land uses. The objective of the present study is to evaluate P removal and recovery processes by ion exchange (IE) with solid carbonate (SC) in biodigestor-treated swine effluent (BTSE) using hydrogeochemical modeling.

Inferring speciation history in the Andes with reduced-representation sequence data: an example in the bay-backed antpittas (Aves; Grallariidae; Grallaria hypoleuca s. l.).

In the Andes, humid-forest organisms frequently exhibit pronounced genetic structure and geographic variation in phenotype, often coincident with physical barriers to dispersal. However, phylogenetic relationships of clades have often been difficult to resolve due to short internodes. Consequently, even in taxa with well-defined genetic structure, the temporal and geographic sequences of dispersal and vicariance events that led to this differentiation have remained opaque, hindering efforts to test the association between diversification and earth history and to understand the assembly of species-rich communities on Andean slopes.

The keepers of the ring: regulators of FtsZ assembly.

FtsZ, a GTPase distributed in the cytoplasm of most bacteria, is the major component of the machinery responsible for division (the divisome) in Escherichia coli. It interacts with additional proteins that contribute to its function forming a ring at the midcell that is essential to constrict the membrane. FtsZ is indirectly anchored to the membrane and it is prevented from polymerizing at locations where septation is undesired.

Hypertension, a health economics perspective.

The economic aspects of hypertension are critical to modern medicine. The medical, economic, and human costs of untreated and inadequately controlled hypertension are enormous. Hypertension is distributed unequally and with iniquity in different countries and regions of the world.

Effect of biological suspensions on the position of the binodal curve in aqueous two-phase systems.

This study is concerned with the influence of biological suspension on the position of the binodal curve in aqueous two-phase systems (ATPSs). Three different biological suspensions (i.e.

Lead based remedies for empacho: patterns and consequences.

This paper discusses research designed to investigate the patterns and consequences of the use of lead based folk remedies in the treatment of some gastrointestinal problems in Mexico. Use of lead is seen in 35% of the population sampled in Guadalajara who treated the folk illness empacho, and 5% of a similar population in Oaxaca. Lead use seems to be associated with mestizo ethnic background, and with lower levels of parental education and income.

[Scintigraphic criteria for the diagnosis of pulmonary embolism].

The natural history of pulmonary embolism is described, together with the physiopathologic alterations and the clinical manifestations of this disease, correlating these with the various patterns of pulmonary perfusion usually found by lung scintigraphy with 99mTc-MAA in patients with thromboembolic lung disease. By using data found in the literature, the operating characteristics (sensitivity, specificity, and accuracy) and the predictive values of the different scintigraphic patterns, were calculated for populations with different prevalences of pulmonary embolism. It is concluded that perfusion lung scintigraphy is a non-invasive, objective and fast procedure, very sensitive to alterations of the regional blood flow, but that is not specific for embolism.

[Cardiac autonomic neuropathy in the diabetic patient].

The importance of cardiac autonomic neuropathy (CAN) derives from its remarkable frequency and its clinical impact. The clinical features are postural hypotension and resting tachycardia, these abnormalities may be overlooked in a high number of patients asymptomatic. Although rarely life threatening, CAN causes considerable morbidity, which can be ameliorated by its identification and appropriate treatment.

Echocardiographic evaluation of patients with rheumatoid arthritis.

Mode M echocardiograms in 34 consecutive adult RA patients revealed no significant differences with the findings obtained in 18 normal controls of similar age and sex. One patient had an 11 mm separation between the anterior chest wall and the right ventricle suggestive of a 350 ml pericardial effusion but had no corresponding findings between the posterior left ventricular wall and the pericardium. In this patient the electrocardiogram showed low voltage and the chest roentgenogram an enlarged cardiac silhouette.

[Comparison between echocardiographic and hemodynamic indices in the evaluation of mitral stenosis].

The echocardiographic data (the amplitude of the mitral echogram, the velocity of the E to F slope and the dimension of the left atrium) of 12 patients with mitral stenosis were compared with hemodynamic data obtained during a cardiac catheterization (the mitral valve area and the peak left ventricular filling rate, expressed in millimeters/second [dv/dtD] and normalized by the end-diastolic volume [dv/dtD/VTD seg-1]). None of the echocardiographic variables showed a good correlation with the hemodynamic indices. It is concluded that echocardiography is a useful total in the diagnosis of mitral stenosis, but at the same time there is not a single echocardiographic sign which by itself evaluate correctly the severity of mitral stenosis.