[A new PiN mutation at the Pi locus in human populations].

By a bidimensional immuno-isofocalisation electrophoresis method a new PiN allel was revealed in 365 samples collected in a Caucasoïd population from a Central Pyrenees Valley (Les Baronnies). Its high frequency (0,151) contributes to the decrease of the PiM one. The different NS, MN and NN phenotypes were formerly classed respectively as MS and MM phenotypes.

[Quantitative study of the genetics of haptoglobin levels].

A quantitative study, based on several African and Pyrenean populations led to the estimate of the effect of some factors on haptoglobin rate: it shows an influence of age and electrophoretic phenotype, but no apparent effect of sex. Moreover, this study led to the conclusion that there is heritability of haptoglobin rate.

[The phenotype Hp O in several African and Central American populations].

This work shows the higher probability for some individuals of having Hp O phenotype: that is, children under twelve, and individual carriers of haemoglobin S (haemoglobin D carriers do not present this characteristic). This observation appears as a confirmation of the hypotheses explaining Hp O phenotype as a consequence of haemolytic anaemia. Besides, the test of two genetic models taking into account both Hp O and Hp21 M phenotypes leads to strong difficulties due to a certain irregularity of "haptoglobin" genetic system.

[Lymphocytic infiltration in human gliomas].

A histological study of lymphocytic infiltration has been undertaken following removal at operation of one hundred human gliomas. This study has been completed with eight cases of tumour recurrence, six attempted autologous grafts, twenty one post-mortems and fourteen explorations of delayed hypersensitivity reactions. About half of the glioma specimens showed lymphocytic infiltration and no reaction was present in the other.

Distribution of haptoglobin subtypes in French Basques.

THE Hl1f, Hp1s and Hp2 gene frequencies were studied in two French population samples: one from the Toulouse area and one from a Basque district. The hp alpha1F and alpha1S polypeptide chains were determined by a simple technique. The observations were in accordance with previous findings in Caucasoid populations.

Polymorphism of the CA-I locus of carbonic anhydrase in baboon.

Polymorphism of erythrocytic carbonic anhydrase was studied by means of the usual technique of starch gel electrophoresis in Papio papio, Papio hamadryas, Papio cynocephalus and Papio anubis. In a sample containing both Papio cynocephalus and Papio anubis, examples of the homozygote CA-Ib/CA-Ib were found. A study of parental transmission established the CA-Ib allelic form.