Publications by authors named "CIPRIANI A"
Importance: Patients with transthyretin (ATTR) cardiac amyloid infiltration are increasingly diagnosed at earlier disease stages with no heart failure (HF) symptoms and a wide range of cardiac amyloid infiltration.
Objective: To characterize the clinical phenotype and natural history of asymptomatic patients with ATTR cardiac amyloid infiltration.
Design, Setting, And Participants: This cohort study analyzed data of all patients at 12 international centers for amyloidosis from January 1, 2008, through December 31, 2023.
Background: Trace amine-associated receptor 1 (TAAR1) agonists offer a new approach, but there is uncertainty regarding their effects, exact mechanism of action and potential role in treating psychosis.
Aims: To evaluate the available evidence on TAAR1 agonists in psychosis, using triangulation of the output of living systematic reviews (LSRs) of animal and human studies, and provide recommendations for future research prioritisation.
Method: This study is part of GALENOS (Global Alliance for Living Evidence on aNxiety, depressiOn and pSychosis).
Background: The comparative benefits and harms of available interventions for ADHD in adults remain unclear. We aimed to address these important knowledge gaps.
Methods: In this systematic review and component network meta-analysis (NMA), we searched multiple databases for published and unpublished randomised controlled trials (RCTs) investigating pharmacological and non-pharmacological interventions for ADHD in adults from database inception to Sept 6, 2023.
Tardive Dyskinesia (TD) can occur in people exposed to dopamine receptor antagonists (DRAs). Its clinical management remains challenging. We conducted a systematic review/random-effects network meta-analysis (NMA) searching PubMed/MEDLINE/PsycINFO/ClinicalTrials.
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- The study assessed the effectiveness of a booster HBV vaccine in Italian medical students, revealing that a significant portion had low antibody levels after 15 years.
- Out of 625 students, 355 were given a booster, and 92.77% of those who received it achieved adequate antibody levels after one month.
- Results showed that physical activity improved immune response to the booster, highlighting the importance of maintaining higher pre-booster antibody levels for better vaccine effectiveness.
Article Synopsis
- The study analyzed changes in electrocardiographic (ECG) characteristics in patients with different types of cardiac amyloidosis (AL, ATTRv, and ATTRwt) and looked at their predictive value for patient outcomes.
- In a large sample of 356 patients, it was found that those with ATTRwt had more conduction issues, while AL patients exhibited more signs of low QRS voltage and T wave inversion.
- Overall, the ECG abnormalities progressed similarly in all subtypes, but a longer QRS duration at baseline was associated with worse survival, indicating it could be a potential marker for advanced disease.
Background: Antidepressants' effects are established in randomised controlled trials (RCTs), but not in the real world.
Aims: To investigate real-world comparative effects of antidepressants for depression and compare them with RCTs.
Method: We performed a cohort study based on the QResearch database.
Article Synopsis
- The understanding of cardiac amyloidosis has significantly evolved in the past decade, leading to better diagnostic and treatment methods.
- This complex disease requires collaboration among various medical specialists to ensure timely diagnosis, risk assessment, and effective management.
- The inter-society consensus document aims to standardize diagnostic approaches in Italy and address clinical challenges for healthcare providers working with patients suspected of having cardiac amyloidosis.
Article Synopsis
- The editorial explores what makes academic psychiatry unique and what qualities define psychiatrists as academics.
- It highlights the importance of academic psychiatry in enhancing clinical services and patient care.
- The piece emphasizes the need to inspire and encourage the upcoming generation to pursue careers in academic psychiatry.
Left ventricular non-compaction (LVNC) is a rare heart muscle disease defined by the presence of prominent left ventricular trabeculation, deep intertrabecular recesses, and a thin compact layer. Several hypotheses have been proposed regarding its pathogenesis, with the most recently accepted one being that compact layer and trabeculated layers develop independently according to an "allometric growth". The current gold-standard diagnostic criteria (in particular, the Petersen index non-compaction/compaction ratio > 2.
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- * Researchers will conduct a systematic review, looking at randomized controlled trials for ADHD medications while assessing symptom severity and treatment tolerability.
- * The goal is to utilize a dose-response Bayesian model to determine optimal dosing strategies, enhancing clinical decision-making and potentially improving patient outcomes.
Article Synopsis
- * The NHS faces long waits for specialist mental healthcare, with hundreds of thousands of referrals each month, requiring effective triage from clinicians based on EHR information.
- * The proposed LLM-based model assists clinicians in triaging referrals by analyzing clinical notes, producing recommendations that align with current practices, and is adaptable for use in resource-limited NHS settings.
Article Synopsis
- Arrhythmogenic cardiomyopathy (ACM) is a heart disease characterized by scarring that affects the heart's electrical stability, making diagnosis complicated due to the lack of a single definitive test.
- Initially defined in 1994 and revised in 2010, diagnostic criteria for ACM primarily focused on the right ventricle, but the introduction of the Padua Criteria in 2020 expanded these criteria to include left ventricular variants and emphasized advanced imaging for diagnosis.
- The latest updates, known as the European Task Force criteria, were published in late 2023, further refining the understanding of ACM and highlighting the significance of non-ischemic myocardial scarring and arrhythmogenic risk across different phenotypes.
[Diagnosis of arrhythmogenic cardiomyopathy: 20 years of progress and innovation].
G Ital Cardiol (Rome)
October 2024
Article Synopsis
- * Diagnostic criteria for CMA have transformed since 1994, with significant revisions in 2010 and a critical update in 2020 that introduced pathways for diagnosing left ventricular variants, emphasizing cardiac magnetic resonance imaging.
- * The most recent revisions in 2023 by the European Task Force included an important new concept: "scarring/arrhythmogenic cardiomyopathy," acknowledging the diversity of symptoms and paths of the disease regardless of its cause.
Article Synopsis
- Arrhythmogenic Cardiomyopathy (ACM) is a heart condition that causes problems with how the heart beats and can lead to heart weakness due to scarring in the heart muscle.
- Diagnosing ACM is tricky because there isn't just one test to do it; instead, doctors need to use a combination of different rules and tests.
- Over the years, experts have updated the way they diagnose ACM, starting from the first criteria in 1994 to new guidelines in 2023 that help better understand the condition and its effects on the heart.
Over the last 20 years, the scientific progresses in molecular biology and genetics in combination with the increasing use in the clinical setting of contrast-enhanced cardiac magnetic resonance (CMR) for morpho-functional imaging and structural myocardial tissue characterization have provided important new insights into our understanding of the distinctive aspects of cardiomyopathy, regarding both the genetic and biologic background and the clinical phenotypic features. This has led to the need of an appropriate revision and upgrading of current nosographic framework and pathobiological categorization of heart muscle disorders. This article proposes a new definition and classification of cardiomyopathies that rely on the combination of the distinctive pathobiological basis (genetics, molecular biology and pathology) and the clinical phenotypic pattern (morpho-functional and structural features), leading to the proposal of three different disease categories, each of either genetic or non-genetic etiology and characterized by a combined designation based on both "anatomic" and "functional" features, i.
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- * A retrospective analysis was conducted on 811 patients from the DIAMOND study, which included a total of 1281 patients diagnosed in Italy between 2016-2021, focusing on characteristics leading to their diagnosis and calculating their respective scores.
- * Findings showed that only 1% of patients had early diagnoses, with significant differences in prognostic variable distribution based on diagnostic pathways, and both NAC and Columbia scores were linked to all-cause mortality.
Objective: To compare all licensed drug interventions as oral monotherapy for the acute treatment of migraine episodes in adults.
Design: Systematic review and network meta-analysis.
Data Sources: Cochrane Central Register of Controlled Trials, Medline, Embase, ClinicalTrials.
Brain-computer interfaces (BCIs) are pivotal in translating neural activities into control commands for external assistive devices. Non-invasive techniques like electroencephalography (EEG) offer a balance of sensitivity and spatial-temporal resolution for capturing brain signals associated with motor activities. This work introduces MOVING, a Multi-Modal dataset of EEG signals and Virtual Glove Hand Tracking.
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- * A committee of headache experts identified clinical questions and reviewed twenty-one national and international guidelines to develop these recommendations.
- * The guidelines outline seventeen questions related to acute migraine treatment, aiming to enhance treatment quality globally, especially in areas with limited medication access.