An intelligent predictive and optimized wastewater treatment plant.

The intelligent predictive and optimized wastewater treatment plant method represents a ground-breaking shift in how we manage wastewater. By capitalizing on data-driven predictive modeling, automation, and optimization strategies, it introduces a comprehensive framework designed to enhance the efficiency and sustainability of wastewater treatment operations. This methodology encompasses various essential phases, including data gathering and training, the integration of innovative computational models such as Chimp-based GoogLeNet (CbG), data processing, and performance prediction, all while fine-tuning operational parameters.

Keeping it human: Pandemic era psychiatry teaching.

Background: Mental health is an important global issue, and doctors in training need a grounding in the principles of psychiatry. Undergraduate clinical placements in psychiatry can develop core knowledge and skills as well as challenging stigma towards mental illness. The onset of the coronavirus pandemic saw disruption to undergraduate clinical placements.

A principal component analysis of 39 scientific impact measures.

Background: The impact of scientific publications has traditionally been expressed in terms of citation counts. However, scientific activity has moved online over the past decade. To better capture scientific impact in the digital era, a variety of new impact measures has been proposed on the basis of social network analysis and usage log data.

Clickstream data yields high-resolution maps of science.

Background: Intricate maps of science have been created from citation data to visualize the structure of scientific activity. However, most scientific publications are now accessed online. Scholarly web portals record detailed log data at a scale that exceeds the number of all existing citations combined.

Cockpit-cabin communication: II. Shall we tell the pilots?

In a previous article (Chute & Wiener, 1995), we explored the coordination between the "two cultures" in an airliner's crew: cockpit and cabin. In this article, we discuss a particular problem: the dilemma facing the cabin crew when they feel that they have safety-critical information and must decide whether to take it to the cockpit. We explore the reasons for the reluctance of the flight attendant to come forward with the information, such as self-doubt about the accuracy or importance of the information, fear of dismissal or rebuke by the pilots, and misunderstanding of the sterile cockpit rule.

Cockpit-cabin communication: I. A tale of two cultures.

Several dramatic accidents have emphasized certain deficiencies in cockpit-cabin coordination and communication. There are historical, organizational, environmental, psychosocial, and regulatory factors that have led to misunderstandings, problematic attitudes, and suboptimal interactions between the cockpit and cabin crews. Our research indicates the basic problem is that these two crews represent two distinct and separate cultures and that this separation serves to inhibit satisfactory teamwork.

Metabolism and storage of catecholamines in rats with pheochromocytoma implants.

New England Deaconess Hospital rats implanted with a pheochromocytoma P259 became hypertensive and showed high concentrations of plasma dopamine (42.0 +/- 14.6 ng/ml) and norepinephrine (45.

Effect of pheochromocytoma and hypophysectomy on blood pressure and catecholamines in NEDH rats.

The New England Deaconess Hospital (NEDH) rat provides a valuable model with which to study pheochromocytoma (P); 59% of male rats 700 to 900 days old and 81% of those 900 days or older developed spontaneous P. One transplantable P (P259), when implanted into other NEDH rats, markedly increased plasma norepinephrine and dopamine as well as blood pressure, and usually caused death within 4 weeks. Even without P, about 83% of NEDH rats became hypertensive by 131/2 weeks of age and remained moderately hypertensive until 2 years of age when some animals developed spontaneous P and hypertension became severe.

Mesothelioma relative to asbestos, radiation, and methylcholanthrene.

The carcinogenicity of chrysotile asbestos fibers (Canadian and Rhodesian) for the mesothelium of pleura and peritoneum of NEDH rats was explored by injection of 2 mg of asbestos fibers suspended in saline intratracheally, intrapleurally, or intraperitoneally, with or without ancillary radiation treatment (1,000 rad to the whole body of parabiont rats or 2,000 rad to the right thorax of single rats), or alternatively, by injection of asbestos plus 1 mg of 3-methylcholanthrene. A highly significant incidence of mesothelioma (3.8%) was noted in 159 rats treated with asbestos alone, as compared with 0.

Serially transplantable chemically induced rat islet cell tumor.

A serially transplantable, chemically induced pancreatic islet cell tumor was developed in Lewis rats. The original tumor was induced by the administration of streptozotocin and nicotinamide. It was subsequently maintained by ip or sc transplantation of tissue fragments into recipient animals.

Hormonally induced tumors of the reproductive system of parabiosed male rats.

Parabiosis of intact male rats to castrated males or oophorectomized females for a period of approximately 20 months resulted in three interstitial cell tumors of the testis. When unilateral nephrectomy was added to the parabiotic procedure in ten pairs, eight interstitial cell tumors of the testis and four adenocarcinomas of the prostate occurred in the target male parabionts. These changes were preceded by elevations in luteinizing and follicle-stimulating hormone levels in the serum of the castrates and high levels of testosterone and, to a lesser degree, of androstenedion in the target partners developing the tumors.

Is breast cancer a result of endocrine targeting? (How women differ from rats or mice).

Parabiosis of female rats with castrate males or oophorectomized females produces carcinoma of the breast in the majority of intact females. When unilateral nephrectomy of each partner is added to the procedure, the incidence is 100 percent. Radioimmunoassays for luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin, estradiol and progesterone have been performed on the sera of these rats.

Late effects of successive massive doses of radiation on parabiont rat pairs.

Parabiosis of rats permits one partner to survive 1000 R X-radiation if the other is shielded. This dose to the previously shielded partner after intervals of 5, 10 or 30 days tests the ability of the first irradiated partner to recover and, in turn, support the second. The effectiveness of this can be measured by the late effects induced in the pair.

A transplantable insulinoma in the rat.

A transplantable insulinoma was developed in inbred albino rats of the NEDH strain. The original tumor, 1 cm in diameter, was removed from the pancreas of a male parabiont 566 days folowing 1000 rads (10J/kg) of total body x-irradiation. The time required for implanted fragments to grow to 0.

The effect of nephrectomy on the incidence of breast carcinoma in irradiated parabiosed rats.

The incidence of carsinoma the breast in parabiosed female NEDH rats is 2.5%. When one member of such a pair is irradiated, the incidence rises to 11% in the irradiated partner and 10% in the nonirradiated partner.

The effect of parabiosis on life-span of rats stressed by radiation.

The life-spans of four series of NEDH rats were compared: (1) single control rats, (2) single rats irradiated with 1000 R, (3) control parabiont rats, (4) parabiont rats one of which had received 1000 R. The stress of radiation (1000 R) produced a median life shortening of 571 days in single rats. Parabiosis followed by irradiation (1000 R) of a member of the pair shortened life 132 days.