The use of cannabidiol as adjunctive therapy in adult patients with drug-resistant epilepsy: a systematic review and meta-analysis.

Background: Highly purified cannabidiol (CBD), recently approved for various neurological disorders, is explored as a potential therapeutic avenue for drug-resistant epilepsy (DRE) among adult people with epilepsy (PWE) in this systematic review and meta-analysis.

Objectives: To conduct an extensive literature review and meta-analysis of CBD use for DRE in adult PWE.

Design: Systematic review and meta-analysis.

Investigating BLS instructors' ability to evaluate CPR performance: focus on compression depth, rate, and recoil.

Background: Out-of-hospital cardiac arrest (OHCA) presents significant challenges with low survival rates, emphasizing the need for effective bystander CPR training. In Basic Life Support (BLS) training, the role of instructors is pivotal as they assess and correct learners' cardiopulmonary resuscitation (CPR) techniques to ensure proficiency in life-saving skills. This study evaluates the concordance between CPR quality assessments by Basic Life Support (BLS) instructors and those determined through Quantitative CPR (QCPR) devices, utilizing data from BLS courses conducted at National Cheng Kung University Hospital from October 2017 to April 2018.

Bioinspired Antiswelling Hydrogel Sensors with High Strength and Rapid Self-Recovery for Underwater Information Transmission.

Hydrogel-based sensors typically demonstrate conspicuous swelling behavior in aqueous environments, which can severely compromise the mechanical integrity and distort sensing signals, thereby considerably constraining their widespread applicability. Drawing inspiration from the multilevel heterogeneous structures in biological tissues, an antiswelling hydrogel sensor endowed with high strength, rapid self-recovery, and low swelling ratio was fabricated through a water-induced phase separation and coordination cross-linking strategy. A dense heterogeneous architecture was developed by the integration of "rigid" quadridentate carboxyl-Zr coordination bonds and "soft" hydrophobic unit-rich regions featuring π-π stacking and cation-π interactions into the hydrogels.

High-resolution direct magnetic resonance imaging fistulography with hydrogen peroxide for diagnosing anorectal fistula: A preliminary retrospective study.

Background: Fistula-in-ano is an abnormal tunnel formation linking the anal canal with the perineum and perianal skin. Multiple imagining methods are available to evaluate it, among which magnetic resonance imaging (MRI) is the most advanced noninvasive preoperative method. However, it is limited in its visualization function.

Triangular Margin: Reliable Imaging Feature of Fibrous Dysplasia in Long Bones?

Objective: To determine the utility of a triangular margin as an imaging diagnostic feature for fibrous dysplasia.

Materials And Methods: We retrospectively reviewed all surgically biopsied or managed benign and malignant bone tumors by a single orthopedic oncologist over 19 years (2003 to 2022). A musculoskeletal radiologist and an orthopedic oncologist, both with >10 years of experience, retrospectively evaluated all imaging in consensus.

Large screen size transparent display using spectrum expanded light field holograms.

Holographic displays have the potential to reconstruct natural light field information, making them highly promising for applications in augmented reality (AR), head-up displays (HUD), and new types of transparent three-dimensional (3D) displays. However, current spatial light modulators (SLMs) are constrained by pixel size and resolution, limiting display size. Additionally, existing holographic displays have narrow viewing angles due to device diffraction limits, algorithms, and optical configurations.

High space-bandwidth product DMD holographic display using gradient descent optimization.

Digital micromirror devices (DMDs), owing to their rapid refresh rates and ability to shape particular optical patterns, are key tools for holographic 3D near-eye displays. However, relying on a single-sideband (SSB) filter to eliminate crosstalk from zero-order and conjugate noise leads to an enormous decrease in the utilization of spatial bandwidth product (SBP). In this paper, we develop a new strategy for the binary hologram optimization framework to enable the full utilization of SBP of DMD holographic display by minimizing conjugate noise.

Using optimization approach to design dental implant in three types of bone quality - A finite element analysis.

Background/purpose: The use of finite element (FE) analysis in implant biomechanics offers many advantages over other approaches in simulating the complexity of clinical situations. The aim of this study was to perform an optimization analysis of dental implants with different thread designs in three types of bone quality.

Materials And Methods: The three-dimensional FE model of a mandibular bone block with a screw-shaped dental implant and superstructure was simulated.

Data-driven exploration of weak coordination microenvironment in solid-state electrolyte for safe and energy-dense batteries.

The unsatisfactory ionic conductivity of solid polymer electrolytes hinders their practical use as substitutes for liquid electrolytes to address safety concerns. Although various plasticizers have been introduced to improve lithium-ion conduction kinetics, the lack of microenvironment understanding impedes the rational design of high-performance polymer electrolytes. Here, we design a class of Hofmann complexes that offer continuous two-dimensional lithium-ion conduction channels with functional ligands, creating highly conductive electrolytes.

Background-free luminescent and chromatic assay for strong visual detection of creatinine.

Creatinine is an essential biomarker for the clinical diagnosis and treatment of renal insufficiency. Although fluorescent methods are powerful tools for creatinine detection, almost all reported fluorescent probes rely on short-wavelength excitation and a single fluorescent signal, making them susceptible to environmental and operational conditions. In this study, a near-infrared excited, highly sensitive, and multi-output signal sensing system was established using upconversion nanoparticles and 3,5-dinitrobenzoic acid (DNBA) for synergistic luminescent and colorimetric assay for strong visual detection of creatinine.

Simultaneous EEG-PET-MRI identifies temporally coupled, spatially structured hemodynamic and metabolic dynamics across wakefulness and NREM sleep.

Sleep entails significant changes in cerebral hemodynamics and metabolism. Yet, the way these processes evolve throughout wakefulness and sleep and their spatiotemporal dependence remain largely unknown. Here, by integrating a novel functional PET technique with simultaneous EEG-fMRI, we reveal a tightly coupled temporal progression of global hemodynamics and metabolism during the descent into NREM sleep, with large hemodynamic fluctuations emerging as global glucose metabolism declines, both of which track EEG arousal dynamics.

The impact of psychological resilience on professional commitment among caregiving students in Taiwan: A cross-sectional study.

Aim/objective: To explore the impact of psychological resilience and its dimensions on professional commitment among caregiving students in Taiwan.

Background: Professional commitment is crucial in caregiving professions, yet its relationship with psychological resilience among caregiving students in Taiwan remains underexplored. Understanding this relationship can guide educational strategies to enhance students' professional commitment.

Nurse's perspective: Evaluating importance and satisfaction with hospital patient infotainment terminal.

Background: The Patient Infotainment Terminal (PIT) plays a pivotal role in Smart Health, enabling hospitals to actively pursue the objective of fostering Shared Decision-Making. By providing General information, Medical information, and Entertainment options, the system fosters effective patient-clinician communication and significantly elevates the standard of care.

Objective: This study aimed to investigate how registered nurses utilized the PIT and prioritized functions based on their perception of importance and satisfaction to find out high-importance but low-satisfaction PIT functions.

Rapid iPSC-derived neuromuscular junction model uncovers motor neuron dominance in amyotrophic lateral sclerosis cytopathy.

The neuromuscular junction (NMJ) is essential for transmitting signals from motor neurons (MNs) to skeletal muscles (SKMs), and its dysfunction can lead to severe motor disorders. However, our understanding of the NMJ is limited by the absence of accurate human models. Although human induced pluripotent stem cell (iPSC)-derived models have advanced NMJ research, their application is constrained by challenges such as limited differentiation efficiency, lengthy generation times, and cryopreservation difficulties.

Enhancing public health outcomes with AI-powered clinical surveillance: Precise detection of COVID-19 variants using qPCR and nanopore sequencing.

Background: We aimed to evaluate the efficacy of integrating the Varia5 multiplex assay (qPCR) and whole genome sequencing (WGS) for monitoring SARS-CoV-2, focusing on their overall performance in identifying various virus variants.

Methods: This study included 140 naso-pharyngeal swab samples from individuals with suspected COVID-19. We utilized our self-developed Varia5 multiplex assay, which targets five viral genes linked to COVID-19 mutations, in conjunction with comprehensive genomic analysis performed through whole genome sequencing (WGS) using the Oxford Nanopore system.

Survival disparities among Asian, Native Hawaiian and Pacific Islander (ANHPI) patients with non-Hodgkin lymphoma (NHL) in the United States.

Background: Non-Hodgkin lymphoma (NHL) is the seventh most common cancer among Asian, Native Hawaiian and Pacific Islanders (ANHPIs), yet the risk of death in specific ANHPI subgroups in the US is unknown.

Methods: We used Surveillance, Epidemiology, and End Results data to investigate relative survival and the risk of death among NHL patients in ANHPI subgroups. Cox proportional hazards models were used to estimate hazard ratios and 95% confidence intervals (CI), comparing ANHPI subgroups to non-Hispanic White (NHW) NHL patients for all-cause death and NHL-specific death.

Nozzle Pressure- and Screw Position-Based CAE Scientific Process Parameter Setup for Injection Molding Process.

This study developed a scientific process parameter setup based on nozzle pressure and screw position, with the process parameter search sequence being injection speed, / switchover position, packing pressure, and packing time. Unlike previous studies, this study focuses on the scientific process parameter setup of experiments and simulations, as well as on the implementation of calibration. Experiments and simulations had the same trend of results in the scientific process parameter setup.

The Evaluation of Antibacterial Coatings Against Commonly Found Pathogenic Bacteria in the Environment-Implications for Environmental Safety and Infection Prevention.

Microorganisms, including pathogens that cause skin, respiratory, and urinary tract infections, are widespread in our environment. Despite routine cleaning with bleach and disinfectants, the transmission of pathogens still occurs, leading to potential infectious diseases. This study aimed to determine the antibacterial effect of two coating formulas against common environmental pathogens like , , , , sp.

A Large-Scale Agricultural Land Classification Method Based on Synergistic Integration of Time Series Red-Edge Vegetation Index and Phenological Features.

Agricultural land classification plays a pivotal role in food security and ecological sustainability, yet achieving accurate large-scale mapping remains challenging. This study presents methodological innovations through a multi-level feature enhancement framework that transcends traditional time series analysis. Using Shandong Province, northern China's agricultural heartland, as a case study, we first established a foundation with time series red-edge vegetation indices (REVI) from Sentinel-2 imagery, uniquely combining the normalized difference red edge index (NDRE) and plant senescence reflectance index (PSRI).

MR T2* Map to Predict Worsening Hypertension Control: A Preliminary Study.

Blood pressure measurement is important in monitoring hypertension. However, blood pressure does not provide much information about renal condition in treated hypertension. This study aimed to evaluate renal oxygenation in hypertensive patients using T2* mapping.

Study on Synergistically Improving Corrosion Resistance of Microarc Oxidation Coating on Magnesium Alloy by Loading of Sodium Tungstate and Silane Treatment.

Sodium tungstate (NaWO) was filled into the micropores and onto the surface of a magnesium alloy microarc oxidation (MAO) coating by means of vacuum impregnation. Subsequently, the coating was sealed through silane treatment to synergistically boost its corrosion resistance. The phase composition of the coating was inspected using XRD.

Embedded Ileal Fish Bone Removed via Deep Enteroscopy in a Patient with Abdominal Pain and Hematochezia: A Case Report.

Ingestion of foreign bodies is a prevalent issue in clinical practice, with fish bones being the predominant cause. While the upper gastrointestinal tract is commonly affected, small intestine impactions pose significant diagnostic challenges due to nonspecific symptoms and lack of awareness of foreign body ingestion. Herein, we describe a case presenting with recurrent, unexplained abdominal pain and hematochezia.

Data Mining Models in Prediction of Vancomycin-Intermediate in Methicillin-Resistant (MRSA) Bacteremia Patients in a Clinical Care Setting.

Vancomycin-intermediate (VISA) is a multi-drug-resistant pathogen of significant clinical concern. Various strains can cause infections, from skin and soft tissue infections to life-threatening conditions such as bacteremia and pneumonia. VISA infections, particularly bacteremia, are associated with high mortality rates, with 34% of patients succumbing within 30 days.

Correction: Chang et al. Fabrication of Stromal Cell-Derived Factor-1 Contained in Gelatin/Hyaluronate Copolymer Mixed with Hydroxyapatite for Use in Traumatic Bone Defects. 2021, , 822.

The authors wish to make a change to the published paper [...