Publications by authors named "CHAKRABARTY B"
Objectives: To observe the prevalence of impaired pulmonary function during various phases of the disease course in children aged 5-18 y with dystrophinopathy. The correlation between different parameters of pulmonary dysfunction and motor function was also studied.
Methods: One hundred and thirty-three confirmed cases of Duchenne muscular dystrophy (DMD), fulfilling predefined inclusion and exclusion criteria were evaluated.
Objectives: To determine the prevalence of psychiatric morbidities in survivors of pediatric acute lymphoblastic leukemia (ALL) and to identify any risk factors.
Methods: Survivors of ALL, who had completed their treatment, atleast two or more years ago and now were 6-18 y old were enrolled on the study. The Mini International Neuropsychiatric Interview (M.
Background: The childhood central nervous system (CNS) acquired demyelinating syndromes (ADS) can be monophasic or recurrent, with both having considerable overlap in the first decade of life.
Objectives: The objective of the study was to describe clinical and radiological features, immunological characteristics, response to therapy and difference between monophasic and first episode of recurrent disorders of pediatric-onset CNS ADS.
Methods: Case records of all patients presenting with CNS ADS to the Department of Pediatrics between January 2009 to December 2018 were retrospectively reviewed.
Article Synopsis
- Immune-mediated epilepsy (IME) is a significant type of epilepsy that doesn't respond to typical drugs, requiring quick diagnosis and treatment with immunosuppressants alongside antiseizure medications.
- The study discusses three unrelated children who developed fever, brain dysfunction, and seizures, ultimately testing positive for specific rare antibodies that indicate an immune-related brain condition.
- Imaging showed abnormal brain activity connected to autoimmune encephalitis, and while treatment led to varying levels of seizure control, some behavioral issues remained in all patients, highlighting that early immunosuppression doesn’t always ensure a complete recovery.
Background: We sought to estimate the prevalence and clinical characteristics of paroxysmal sympathetic hyperactivity (PSH) in childhood tuberculous meningitis.
Methods: Hospital records of children (6 months to 14 years) with tuberculous meningitis were retrospectively analyzed from September 2019 through January 2022. In September 2019, the first case of paroxysmal sympathetic hyperactivity in tuberculous meningitis was identified in our division.
Article Synopsis
- Schizophrenia can impair thinking and motivation, and the study investigates the effects of daidzin (DZN) on mice to see if it improves cognitive functions like attention and memory.
- A series of behavioral tests, including marble burying and swimming tasks, were conducted on Swiss mice divided into groups receiving different doses of DZN and a standard drug called olanzapine (OLN).
- Results showed that DZN significantly improved attention and memory-related behaviors, particularly in combination with OLN, while in silico analysis revealed that DZN has strong interactions with serotonin and dopamine receptors, suggesting a potential mechanism for its effects.
We aimed to investigate the potential role of biomarkers of transmethylation, oxidative stress, and mitochondrial dysfunction in children with Autism Spectrum Disorder (ASD) by comparing them with that of typically developing children (TDC) controls. We also tried to correlate them with severity of autism, sensory issues, behavioural comorbidities and developmental quotients 119 with ASD and 52 age and sex matched typically developing children (TDC) controls were enrolled excluding those with chronic-illness or on any antioxidant therapy/multivitamins/anti-epileptic drugs. Median levels of biomarkers - serum homocysteine, cysteine, methionine, urine uric acid-to-creatinine ratio, arterial lactate, serum vitamin E, vitamin B12, folate, Nε-carboxymethyllysine, Nω- carboxymethylarginine (CMA), dityrosine and MTHFR C677T polymorphism were calculated.
View Article and Find Full Text PDFIntroduction: Low-grade appendiceal mucinous neoplasms (LAMNs) are classified as non-perforated (pTis, pT3) or perforated (pT4), and considered precursors of pseudomyxoma peritonei (PMP). This study aims to quantify the risk of developing PMP from pTis and pT3 LAMNs.
Materials And Methods: Retrospective analysis of a prospectively collected database identified LAMN patients referred to a specialist centre from 2004 to 2019.
Objectives: The study compared real-time motor cortex excitability using transcranial magnetic stimulation (TMS)-derived parameters between children with epileptic encephalopathy with spike-wave activation in sleep (EE-SWAS) and age-matched neurotypical controls. The EE-SWAS group received steroids as standard of care and were longitudinally followed for three months.
Materials & Methods: Children aged 5-12 years with immunotherapy-naive EE-SWAS (spike-wave-index≥50 %) and neurotypical controls were enrolled.
Article Synopsis
- - Treatment-induced ototoxicity from chemotherapy or antibiotics can lead to significant hearing loss, making early intervention crucial; this study explores a local delivery method to the inner ear using crosslinked hybrid nanoparticles (cHy-NPs) in a thermoresponsive hydrogel to combat this issue.
- - The study focuses on two therapeutic agents, Flunarizine (a calcium channel blocker) and Honokiol (an antioxidant), co-encapsulated in the nanoparticles to provide cytoprotection against cisplatin-induced toxicity in specific cell models and in living zebrafish.
- - The findings demonstrate that the combination of Flunarizine and Honokiol within the nanoparticles enhances their protective effects; the nanoparticles were successfully synthesized with a high drug
Article Synopsis
- - The study aimed to compare sensory processing abilities of children with cerebral palsy (CP) with typically developing children (TDC), discovering significant differences in sensory skills between the two groups.
- - A total of 150 children with CP and 50 TDC were analyzed using the Child Sensory Profile 2, revealing that 80.7% of the CP group exhibited probable sensory processing differences (SPD), compared to just 26% in TDC.
- - Results indicated that proprioceptive and vestibular processing were the most impacted in children with CP, with many falling into the "bystander" pattern, showing poor awareness of sensory stimuli; no notable differences were found among CP subtypes.
Treatment guidelines provided by PRODIGE-7 recommend perioperative systemic chemotherapy before cytoreductive surgery (CRS) for colorectal cancer peritoneal metastases (CRPM). Toxicity with multimodal treatment needs to be better defined. Chemotherapy response and impact on survival have not been reported.
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- The study investigates the effectiveness of three verbal suggestion techniques during short-term video-electroencephalogram (EEG) recordings to induce psychogenic nonepileptic seizures (PNES) in children aged 5-18 years.
- All three methods showed similar success rates in reproducing events, with verbal suggestion alone being as effective as methods using additional tools like a tuning fork or cotton swab.
- The presence of psychiatric comorbidity was found to be a significant predictor for event reproduction, while the specific suggestion method used did not significantly impact clinical outcomes after 12 weeks.
Background: Currently, clinical assessment is the main tool for the evaluation of brachial plexus injury, complemented by electrophysiologic studies (EPS), and imaging studies whenever available. Imaging plays an important role as it enables the differentiation of pre-ganglionic and postganglionic injuries, and adds objectivity to presurgical evaluation.
Objectives: The primary objective was to evaluate the utility of magnetic resonance imaging (MRI) and high-resolution ultrasonography (USG) in the localization and characterization of brachial plexus injury in infants.
Background: Pathogenic variants in the NDUFV1 gene disrupt mitochondrial complex I, leading to neuroregression with leukoencephalopathy and basal ganglia involvement on neuroimaging. This study aims to provide a concise review on NDUFV1-related disorders while adding the largest cohort from a single center to the existing literature.
Methods: We retrospectively collected genetically proven cases of NDUFV1 pathogenic variants from our center over the last decade and explored reported instances in existing literature.
Waste products in the bloodstream are filtered by the glomerular capillaries in the kidneys and excreted into the urine. When making a differential diagnosis of kidney diseases, structural assessment of glomeruli using histological, ultrastructural, and immunological studies is crucial. This study assessed the microscopic and ultrastructural morphometric parameters of glomerular capillaries and examined their correlation with serum creatinine and proteinuria.
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