Publications by authors named "CAVANNA R"

Article Synopsis
  • - Pain management after pectus excavatum surgery is crucial, yet there's no international consensus on guidelines, prompting the need for research to compare pain relief methods and long-term effects, especially using eHealth solutions for better data collection and patient engagement.
  • - The study, part of the COPPER project by Giannina Gaslini Children's Hospital, aims to evaluate traditional thoracic epidural analgesia against cryoanalgesia, employing a web and mobile app to streamline data collection and analysis effectively.
  • - Preliminary results from a pilot study with 72 patients show successful enrollment and balanced demographics, indicating the app's potential to enhance pain management evaluation and potentially reduce hospital stays.
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The early evaluation of prognostic tumour markers is commonly performed by comparing the survival of two groups of patients identified on the basis of a cut-off value. The corresponding hazard ratio () is usually estimated, representing a measure of the relative risk between patients with marker values above and below the cut-off. A posteriori methods identifying an optimal cut-off are appropriate when the functional form of the relation between the marker distribution and patient survival is unknown, but they are prone to an overestimation bias.

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Background: Although a satisfactory disease control is nowadays achievable in most patients with JIA, a substantial proportion of them still do not respond adequately or reach long-term drug-free remission. According to current recommendations, treatment should be escalated in subsequent steps. A different approach is based on the assumption that the initial start of an aggressive therapy may take advantage of the "window of opportunity" and could alter the biology of the disease, leading to an improvement of long-term outcomes, including the prevention of cumulative joint damage.

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An improved preparation of proteolipid from bovine brain white matter is described. The product obtained by repeated acetone precipitation is completely soluble in chloroform-methanol and has a fairly constant composition: 35% protein, 40% galactocerebroside, and about 25% phospholipid.

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