The Use of Principal Component Analysis for Reduction in Sleep Quality and Quantity Data in Female Professional Soccer.

The main aim of the present study was to uncover multivariate relationships between sleep quantity and quality using principal component analysis (PCA) in professional female soccer players. A second aim was to examine the extent to which objective sleep quantity and quality variables can discriminate between perceived sleep. Ten objective sleep variables from the multisensory sleep-tracker were analyzed.

APOE genotype and brain amyloid are associated with changes in the plasma proteome in elderly subjects without dementia.

Objective: Recent work has bolstered the possibility that peripheral changes may be relevant to Alzheimer's disease pathogenesis in the brain. While age-associated blood-borne proteins have been targeted to restore function to the aged brain, it remains unclear whether other dysfunctional systemic states can be exploited for similar benefits. Here, we investigate whether APOE allelic variation or presence of brain amyloid are associated with plasma proteomic changes and the molecular processes associated with these changes.

Computational Prognostic Modeling in Traumatic Brain Injury.

Traumatic brain injury is the leading cause of death and disability worldwide. Despite this large impact, no predictive models are in widespread use due to tedious data collection requirements, lack of provider trust, and poor performance. Furthermore, these models use simple, often binary, data elements that fail to capture the complex heterogeneity of traumatic brain injury.

Very high-speed running (VHSR) profile in elite female football: An update.

The aim of the present study it's a providing an update of the profile of very high-speed running (VHSR) of professional female football players. In this study 23 official matches of the Spanish First Division of Women´s Football were analysed. A total of 15 players participated, who were classified according to their location on the matches played: central-corridor (CCP, n = 7), and lateral-corridor (LCP, n = 8).

Emerging roles of lipid and metabolic sensing in the neuroendocrine control of body weight and reproduction.

The hypothalamus lies at the intersection of brain and hormonal mechanisms governing essential bodily functions, including metabolic/body weight homeostasis and reproduction. While metabolism and fertility are precisely regulated by independent neuroendocrine axes, these are tightly connected, as reflection of the bidirectional interplay between the energy status of the organisms and their capacity to reproduce; a connection with important pathophysiological implications in disorders affecting these two crucial systems. Beyond the well-characterized roles of key hormones (e.

Discovering genes and microRNAs involved in human lung development unveils IGFBP3/miR-34a dynamics and their relevance for alveolar differentiation.

Background: During pseudoglandular stage of the human lung development the primitive bronchial buds are initially conformed by simple tubules lined by endoderm-derived epithelium surrounded by mesenchyme, which will progressively branch into airways and start to form distal epithelial saculles. For first time alveolar type II (AT2) pneumocytes appears. This study aims to characterize the genes and microRNAs involved in this differentiation process and decipher its role in the starting alveolar differentiation.

Prognostic value of the 5-SENSE Score to predict focality of the seizure-onset zone as assessed by stereoelectroencephalography: a prospective international multicentre validation study.

Introduction: Epilepsy surgery is the only curative treatment for patients with drug-resistant focal epilepsy. Stereoelectroencephalography (SEEG) is the gold standard to delineate the seizure-onset zone (SOZ). However, up to 40% of patients are subsequently not operated as no focal non-eloquent SOZ can be identified.

Identification of Meibomian gland stem cell populations and mechanisms of aging.

Meibomian glands secrete lipid-rich meibum, which prevents tear evaporation. Aging-related Meibomian gland shrinkage may result in part from stem cell exhaustion and is associated with evaporative dry eye disease, a common condition lacking effective treatment. The identities and niche of Meibomian gland stem cells and the signals controlling their activity are poorly defined.

Associations of Circulating Biomarkers with Disease Risks: a Two-Sample Mendelian Randomization Study.

Background: Circulating biomarkers play a pivotal role in personalized medicine, offering potential for disease screening, prevention, and treatment. Despite established associations between numerous biomarkers and diseases, elucidating their causal relationships is challenging. Mendelian Randomization (MR) can address this issue by employing genetic instruments to discern causal links.

Associations of Circulating Biomarkers with Disease Risks: A Two-Sample Mendelian Randomization Study.

Circulating biomarkers play a pivotal role in personalized medicine, offering potential for disease screening, prevention, and treatment. Despite established associations between numerous biomarkers and diseases, elucidating their causal relationships is challenging. Mendelian Randomization (MR) can address this issue by employing genetic instruments to discern causal links.

Exploring the Relationship of Declarative Tactical Knowledge With Participation, Football Competence, and Potentiality in a Professional Club (Real Sociedad).

We compared the declarative tactical knowledge (DTK) of 196 male and female players (16.9 ± 2.4 years) belonging to the academy of a Spanish professional football club with their participation (minutes played), football competence (coaching staff assessment), and future potential (technical direction prediction).

Early Seizure Prophylaxis in Mild and Moderate Traumatic Brain Injury: A Systematic Review and Meta-Analysis.

Importance: Guidelines recommend seizure prophylaxis for early posttraumatic seizures (PTS) after severe traumatic brain injury (TBI). Use of antiseizure medications for early seizure prophylaxis after mild or moderate TBI remains controversial.

Objective: To determine the association between seizure prophylaxis and risk reduction for early PTS in mild and moderate TBI.

Insights into epileptogenesis from post-traumatic epilepsy.

Post-traumatic epilepsy (PTE) accounts for 5% of all epilepsies. The incidence of PTE after traumatic brain injury (TBI) depends on the severity of injury, approaching one in three in groups with the most severe injuries. The repeated seizures that characterize PTE impair neurological recovery and increase the risk of poor outcomes after TBI.

Clinical characteristics and outcomes among hospitalised COVID-19 patients across epidemic waves in Spain: An unCoVer analysis.

Background And Objectives: The COVID-19 pandemic had a significant impact in population health worldwide, and particularly in people with pre-existing chronic diseases. Early risk identification and stratification is essential to reduce the impact of future outbreaks of pandemic potential. This study aimed to comprehensively examine factors associated with COVID-19 mortality across the pandemic waves in Spain.

Tell me how much your opponent team runs and I will tell you how much you should run: A predictive model applied to Spanish high-level football.

The aim of this study was to predict a team's accumulated distance (TotDisTea) and accumulated distance at > 21 km/h (TotDis21Tea) in the Spanish Football First Division. 2,946 team physical performances (out of 3040 possible) during four seasons (from 2016-17 to 2019-20) were analysed. The outcome variables were the TotDisTea and TotDis21Tea when the ball was in play.

In vitro and in vivo evaluation of the efficacies of commercial probiotics and disinfectant against acute hepatopancreatic necrosis disease and luminescent vibriosis in Litopenaeus vannamei.

The bioactivities of two commercially available probiotics and one chemical disinfectant were tested against strains of Vibrio parahaemolyticus (VP) and V. harveyi. This study aimed to determine shrimp pathogenic Vibrios' in vitro and in vivo sensitivities to commercial probiotics and a chemical disinfectant.

An eight-season analysis of the teams' performance in the Spanish LaLiga according to the final league ranking.

This study aimed to analyse the performance of 5,518 collective observations of the Spanish LaLiga teams for eight consecutive seasons (from 2011-12 to 2018-19), considering the final league ranking. The teams were divided into four groups: Europe (from 1st to 6th), Upper-Middle (from 7th to 11th), Lower-Middle (from 12th to 17th) and Relegation (from 18th to 20th). The variables recorded were: Passes, Successful Passes, Crosses, Shots, Goals, Corners, Fouls, Width, Length, Height, distance from the goalkeeper to the nearest defender (GkDef), total distance covered (TD) and number of points accumulated.

Stereoelectroencephalography-Guided Radiofrequency Thermocoagulation: Diagnostic and Therapeutic Implications.

Despite recent medical therapeutic advances, approximately one third of patients do not attain seizure freedom with medications. This drug-resistant epilepsy population suffers from heightened morbidity and mortality. In appropriate patients, resective epilepsy surgery is far superior to continued medical therapy.

Two periodization strategies in professional football and their influence on accumulated training load and its distribution: Differences between starters and non-starters.

This study compared weekly training-load (TL), training-monotony (TM), and training-strain (TS) in 80 professional football players (28.1 ± 3.2 yrs, 78.

Interplay of Postprandial Triglyceride-Rich Lipoprotein Composition and Adipokines in Obese Adolescents.

In the context of the alarming rise of infant obesity and its health implications, the present research aims to uncover disruptions in postprandial lipid metabolism and the composition of triglyceride-rich lipoproteins in obese adolescents. A double-blind, controlled clinical trial in the postprandial phase on 23 adolescents aged 12 to 16 years was carried out. Twelve participants were categorized as obese (BMI > 30 kg/m and percentile > 95) and 11 as normal-weight (BMI = 20-25 kg/m, percentile 5-85).

Do small-sided games prepare players for the worst-case scenarios of match play in elite young soccer players?

The aim of the study was to determine whether the physical performance of young soccer player during various small sided games (SSGs) underloads, replicates or overloads the requirements of the worst-case scenarios (WCS) during match play. A total of 521 SSGs' individual observations and 15 different formats of SSGs with different areas per player (ApP) (ApP100: < 100; ApP200: ranged from 101 to 200; ApP300: > 201, all in m · player) were taken into consideration. Whole (90-min average; OM) and 15-, 5- and 1-min worst-case scenarios (WCS15, WCS5 and WCS1, respectively) were analysed.