Preference for Long-Acting Injectable PrEP Compared With Daily Oral PrEP Among Transgender Women in the U.S.: Findings From a Multisite Cohort.

Introduction: Pre-exposure prophylaxis (PrEP) use among transgender women in the U.S. has not reached levels optimal to change the trajectory of the HIV epidemic owing to multilevel barriers.

"Courting" the Hidden Curriculum: Depictions of Sexuality and Implications for Heteronormativity in ELT Materials from Taiwan.

While the Taiwan government has embraced a progressive stance toward LGBT rights, especially through legalization of same-sex marriage and the adoption of educational policy aimed at promoting LGBT rights in the schools, there is little sense of the role of English language teaching (ELT) in this issue. Since English study is important in Taiwan, this project responded by employing hidden curriculum theory to address the possible role of English language teaching (ELT) materials authored and used in Taiwan in reproducing or disrupting the marginalization of LGBT people. This study operationalized the target hidden curriculum as instantiations of norms implicit within sexuality representations such as depictions of dating behaviors and family structures.

Magnified interaural level differences enhance binaural unmasking in bilateral cochlear implant users.

Bilateral cochlear implant (BiCI) usage makes binaural benefits a possibility for implant users. Yet for BiCI users, limited access to interaural time difference (ITD) cues and reduced saliency of interaural level difference (ILD) cues restricts perceptual benefits of spatially separating a target from masker sounds. The present study explored whether magnifying ILD cues improves intelligibility of masked speech for BiCI listeners in a "symmetrical-masker" configuration, which ensures that neither ear benefits from a long-term positive target-to-masker ratio (TMR) due to naturally occurring ILD cues.

A multi-cohort study of longitudinal and cross-sectional Alzheimer's disease biomarkers in cognitively unimpaired older adults.

Introduction: The generalizability of neuroimaging and cognitive biomarkers in their sensitivity to detect preclinical Alzheimer's disease (AD) and power to predict progression in large, multisite cohorts remains unclear.

Method: Longitudinal demographics, T1-weighted magnetic resonance imaging (MRI), and cognitive scores of 3036 cognitively unimpaired (CU) older adults (amyloid beta [Aβ]-negative/positive [A-/A+]: 1270/1558) were included. Cross-sectional and longitudinal cognition and medial temporal lobe (MTL) structural measures were extracted.

Tau Burden is Best Captured by Magnitude and Extent: Tau-MaX as a Measure of Global Tau.

Tau exhibits change in both spatial extent and density of pathology along the Alzheimer's disease (AD) spectrum with each aspect contributing to the overall burden of pathological tau. Nevertheless, studies using Tau PET have measured either magnitude using standardized uptake value ratios (SUVRs) or extent using number of Tau+ regions. We hypothesized that combining these two dimensions into a single measure of Magnitude and eXtent, Tau-MaX, would provide improved quantification of global tau burden as well as allowing for a region-agnostic measure of global tau burden that does not require a pre-specified region of interest (ROI) or meta-ROI.

An integrated approach to coupled nutrient and microbial source tracking in an agricultural watershed.

Estuaries often experience multiple water quality impairments including nitrogen enrichment and elevated fecal pollution. These pollutant sources are often linked and difficult to characterize, especially in multiple use watersheds, hindering the identification of effective mitigation steps. Tillamook Bay (Oregon, USA) has a mixed-use watershed including many potential nutrient and fecal bacteria sources due to agricultural activities, human development, and local wildlife populations.

Systematic Review of Evidence for Conservative Management of Pelvic Organ Prolapse in Younger Women.

Introduction: Treatment of pelvic organ prolapse (POP) is poorly understood in younger women as the majority of prolapse research is conducted in the older population. There is an urgent need to evaluate conservative POP treatments for management in younger women due to high surgical complications and reoperation rates.

Methods: Systematic review of the literature following PRISMA guidelines and registered in PROSPERO.

Prediction of Human Papillomavirus-Host Oncoprotein Interactions Using Deep Learning.

Background: Human papillomavirus (HPV) causes disease through complex interactions between viral and host proteins, with the PI3K signaling pathway playing a key role. Proteins like AKT, IQGAP1, and MMP16 are involved in HPV-related cancer development. Traditional methods for studying protein-protein interactions (PPIs) are labor-intensive and time-consuming.

Preference for Long-Acting HIV Prevention Methods Among Transgender Women Vulnerable to HIV in Eastern and Southern United States: Findings from the LITE Study.

HIV incidence among transgender women remains high and disproportionately impacts young, Black, and Latina transgender women. Data on preferred PrEP modalities among this population are limited. Participants in The LITE Cohort completed a survey module on PrEP modality preferences during 24-month study visits.

HSP90 inhibitor AUY922 suppresses tumor growth and modulates immune response through YAP1-TEAD pathway inhibition in gastric cancer.

Heat shock protein 90 (HSP90), a vital chaperone involved in the folding and stabilization of various cellular proteins, regulates key functions in many tumor cells. In the context of gastric adenocarcinoma (GAC), where HSP90's role remains largely unexplored, we aimed to investigate the significance of HSP90 inhibitor, AUY922, in regulating the YAP1/TEAD pathway and its association with the tumor immune microenvironment (TME). Our results showed that AUY922 effectively inhibited GAC aggressiveness in both the invitro and invivo models, induced apoptosis, and cell-cycle arrest.

BOLD Amplitude Correlates of Preclinical Alzheimer's Disease.

Alzheimer's disease (AD) is characterized by a long preclinical stage during which molecular markers of amyloid beta and tau pathology rise, but there is minimal neurodegeneration or cognitive decline. Previous literature suggests that measures of brain function might be more sensitive to neuropathologic burden during the preclinical stage of AD than conventional measures of macrostructure, such as cortical thickness. However, among studies that used resting-state functional Magnetic Resonance Imaging (fMRI) acquisitions with Blood Oxygenation Level Dependent (BOLD) contrast, most employed connectivity-based analytic approaches, which discard information about the amplitude of spontaneous brain activity.

Feedbacks Between Estuarine Metabolism and Anthropogenic CO Accelerate Local Rates of Ocean Acidification and Hasten Threshold Exceedances.

Attribution of the ocean acidification (OA) signal in estuarine carbonate system observations is necessary for quantifying the impacts of global anthropogenic emissions on water quality, and informing managers of the efficacy of potential mitigation options. We present an analysis of observational data to characterize dynamics and drivers of seasonal carbonate system variability in two seagrass habitats of Puget Sound, WA, USA, and estimate how carbon accumulations due to anthropogenic emissions interact with these drivers of carbonate chemistry to determine seasonally resolved rates of acidification in these habitats. Three independent simulations of accumulation from 1765 to 2100 were run using two previously published methods and one novel method for estimation.

The experience of occupational therapists and physiotherapists using a prototype, evidence-informed online knowledge translation resource to learn about patient-defined, personally-meaningful chronic pain rehabilitation.

Purpose: Chronic pain is a complex biopsychosocial experience, and rehabilitation helps people to manage pain, and restore valued life roles. Evidence suggests that more positive outcomes occur when clients perceive their rehabilitation to be meaningful. People with chronic pain describe rehabilitation as personally-meaningful when they develop a genuine connection with a credible therapist who they see as a guiding partner, and when rehabilitation holds personal value, is self-defined, and relevant to their sense of self-identity.

Ventilation does not affect close-range transmission of influenza virus in a ferret playpen setup.

Sustained community spread of influenza viruses relies on efficient person-to-person transmission. Current experimental transmission systems do not mimic environmental conditions (e.g.

Magnified interaural level differences enhance binaural unmasking in bilateral cochlear implant users.

Bilateral cochlear implant (BiCI) usage makes binaural benefits a possibility for implant users. Yet for BiCI users, limited access to interaural time difference (ITD) cues and reduced saliency of interaural level difference (ILD) cues restricts perceptual benefits of spatially separating a target from masker sounds. The present study explored whether magnifying ILD cues improves intelligibility of masked speech for BiCI listeners in a "symmetrical-masker" configuration, which ensures that neither ear benefits from a long-term positive target-to-masker ratio (TMR) due to naturally occurring ILD cues.

Positive Association between Patients' Perception of Chronic Pain Rehabilitation as a Personally Meaningful Experience and the Flourishing Aspect of Well-Being.

Chronic pain rehabilitation helps to reduce pain and restore valued life roles. Patients may have more positive outcomes when they perceive rehabilitation to be personally meaningful. This study examined associations between self-reported, personally meaningful rehabilitation and well-being.