Publications by authors named "C-Z Liu"
Fe-loaded red radish anthocyanin (RRA) and zein composite nanoparticles (FZNPs) were firstly prepared to enhance the color and stability of RRA. The addition of Fe caused anthocyanin to form color chelates, enhancing its pH color sensitivity. The prepared FZNPs showed good stability and anthocyanin retention during long-term storage.
View Article and Find Full Text PDFBackground: We performed a prespecified subgroup analysis of the CATIS-2 trial (China Antihypertensive Trial in Acute Ischemic Stroke II) to compare the effect of early versus delayed antihypertensive treatment on death and disability in patients with and without medical history of hypertension.
Methods: CATIS-2 is a multicenter randomized clinical trial conducted in 106 hospitals in China. The trial randomized 4810 patients with acute ischemic stroke within 24 to 48 hours of symptom onset and elevated systolic blood pressure between 140 and <220 mm Hg to receive antihypertensive treatment immediately after randomization or to discontinue antihypertensive medications for 7 days and then receive treatment on day 8.
Optogenetics is a valuable tool for studying the mechanisms of neurological diseases and is now being developed for therapeutic applications. In rodents and macaques, improved channelrhodopsins have been applied to achieve transcranial optogenetic stimulation. While transcranial photoexcitation of neurons has been achieved, noninvasive optogenetic inhibition for treating hyperexcitability-induced neurological disorders has remained elusive.
View Article and Find Full Text PDFBackground Interest in microwave ablation (MWA) and radiofrequency ablation (RFA) use for treating secondary hyperparathyroidism (SHPT) is rising; however, ablation outcomes in patients with SHPT are not well characterized. Purpose To assess the response of parathyroid hormone (PTH), calcium, phosphorus, and alkaline phosphatase (ALP) levels to US-guided parathyroid MWA and RFA and the safety of these treatments in participants with SHPT. Materials and Methods This prospective multicenter cohort study, conducted from September 2017 to March 2022, included participants with SHPT.
View Article and Find Full Text PDFBackground: For non-small-cell lung cancer (NSCLC) patients who progressed after first-line chemotherapy, immunotherapy targeting programmed cell death (ligand) 1 has shown promising activity. However, the activity is relatively limited in patients harboring epidermal growth factor receptor (EGFR) mutations.
Objectives: This study aimed to evaluate the efficacy and safety of camrelizumab plus famitinib in previously treated patients with locally advanced and metastatic NSCLC.
Background: Mechanosensitive Piezo1 channel plays a key role in pulmonary hypertension (PH). However, the role of Piezo2 in PH remains unclear.
Methods: Endothelial cell (EC)-specific knockout (, Tek-Cre; ) rats and primarily cultured pulmonary microvascular ECs were used to determine the role of Piezo2 in PH.
Background: CDK4/6 inhibitors are highly valued, but the incidence of cardiovascular adverse events (CVAEs) associated with CDK4/6 inhibitors is not clear.
Objective: Our aim was therefore to assess the risk of developing CVAEs associated with CDK4/6 inhibitors, by conducting a systematic review and meta-analysis of randomized controlled trials (RCTs), along with a pharmacovigilance study of the FDA Adverse Event Reporting System (FAERS) database.
Methods: Eligible CVAEs were extracted from the ClinicalTrials.
Article Synopsis
- Researchers developed a deep learning model (XDL) using superb microvascular imaging (SMI) to noninvasively assess interstitial fibrosis (IF) in chronic kidney disease (CKD) patients.
- The study included 365 CKD patients who underwent renal biopsies, ultrasounds, and SMI exams, categorizing their IF levels into minimal-mild and moderate-severe.
- The XDL model outperformed traditional ultrasound radiomics and color Doppler ultrasonography in diagnostic accuracy, with additional tools like pie charts and heat maps enhancing the model's interpretability by highlighting important image regions for diagnosis.
Background: Pulmonary hypertension (PH) is associated with endothelial dysfunction. However, the cause of endothelial dysfunction and its impact on PH remain incompletely understood. We aimed to investigate whether the hypoxia-inducible FUNDC1 (FUN14 domain-containing 1)-dependent mitophagy pathway underlies PH pathogenesis and progression.
View Article and Find Full Text PDFHigh-internal-phase water-in-oil (W/O) emulsions generated in situ have garnered considerable attention as novel profile control systems. However, conventional emulsifiers are unreactive and poorly dispersed in water, necessitating large dosages and resulting in poor injectivity. In this study, we synthesized amphiphilic nanoparticles (SiO-NH-DAC NPs) containing amine and long-chain alkyl groups using a one-pot method and investigated the stabilized emulsion properties.
View Article and Find Full Text PDFA fascinating feature of land plants is their ability to continually initiate new tissues and organs throughout their lifespan, driven by a pool of pluripotent stem cells located in meristems. In seed plants, various types of meristems are initiated and maintained during the sporophyte generation, while their gametophytes lack meristems and rely on sporophyte tissues for growth. In contrast, seed-free vascular plants, such as ferns, develop meristems during both the sporophyte and gametophyte generations, allowing for the independent growth of both generations.
View Article and Find Full Text PDFPurpose To develop a deep learning model for the morphologic measurement of unruptured intracranial aneurysms (UIAs) based on CT angiography (CTA) data and validate its performance using a multicenter dataset. Materials and Methods In this retrospective study, patients with CTA examinations, including those with and without UIAs, in a tertiary referral hospital from February 2018 to February 2021 were included as the training dataset. Patients with UIAs who underwent CTA at multiple centers between April 2021 and December 2022 were included as the multicenter external testing set.
View Article and Find Full Text PDFRationale And Objectives: Endovascular recanalization has been attempted in patients with symptomatic chronic intracranial large artery occlusion (CILAO), however, the heterogeneity of recanalization outcomes present challenges for the clinical application.
Objective: To determine the radiological features on high-resolution MR imaging (HR-MRI) for predicting successful recanalization of symptomatic CILAO.
Methods: Seventy-three patients with symptomatic CILAO who underwent endovascular recanalization at our center were retrospectively analyzed.
Background: Phenylacetylglutamine is implicated in platelet clotting and thrombosis, but its prognostic value in ischemic stroke remains unclear. We aimed to explore the associations of plasma phenylacetylglutamine levels with adverse outcomes after ischemic stroke in a multicenter prognostic cohort study.
Methods: Our multicenter prognostic cohort study included 3564 Chinese patients with ischemic stroke from the CATIS (China Antihypertensive Trial in Acute Ischemic Stroke).
Background And Objectives: The incidence of stroke among young adults was rising globally, but the death burden of stroke in young adults in China is lacking. We aimed to examine the temporal trends in mortality and years of life lost (YLLs) caused by stroke among young adults from 2005 to 2020 across China.
Methods: Based on the data from the National Mortality Surveillance System in China, we estimated the number and age-standardized rate of mortality and YLLs due to stroke and its subtypes among young adults aged 15-49 years during 2005-2020, for both China and its 31 mainland provinces.
Circulating Tumor DNA in Conjunctival Melanoma: Landscape and Surveillance Value.
Am J Ophthalmol
February 2025
Purpose: To evaluate the surveillance value of circulating tumor DNA (ctDNA) for detecting distant metastasis and indicating systemic therapeutic efficacy in conjunctival melanoma (CoM).
Design: Retrospective, observational case series.
Methods: From July 2021 to June 2023, 30 CoM patients in our center underwent plasma ctDNA assessment, out of which 12 individuals presented with distant metastases.
Article Synopsis
- Anti-PD-1 immunotherapy combined with chemotherapy has been shown to significantly extend survival rates for patients with squamous cell lung cancer (LUSC), but further research is needed to identify predictive biomarkers for treatment response.
- The study involved RNA sequencing of 349 LUSC samples and additional experiments, revealing that a high presence of activated CD8 T and CD56 natural killer (NK) cells correlates with better patient outcomes.
- Researchers established a new classification system based on tumor cornification and immune cell infiltration, which could help predict the effectiveness of the combination treatment and highlight potential immune evasion mechanisms in certain tumor cells.
Article Synopsis
- The study aims to assess the occurrence and characteristics of macular retinoschisis (MRS) in individuals with high myopia within a Chinese population.
- Conducted as a population-based, cross-sectional analysis, the study involved 213 highly myopic eyes from 129 participants who underwent optical coherence tomography scans.
- The findings revealed a 22.5% prevalence of MRS among the eyes, with key risk factors identified including older age, higher intraocular pressure, thinner choroidal thickness, glaucoma, and the presence of an epiretinal membrane.
Article Synopsis
- There is no consensus on the best timing for combining transjugular intrahepatic portosystemic shunt (TIPS) and partial splenic embolization (PSE) in patients with cirrhosis-related issues, prompting this study to compare early versus late treatment combinations.
- The study involved 84 patients and found that those who received the late combination of TIPS and PSE had better survival rates and lower instances of overt hepatic encephalopathy (OHE) compared to those who underwent the early combination.
- Key factors affecting mortality and OHE included the timing of the procedure and serum albumin levels, with early combination therapy linked
Article Synopsis
- * The study analyzed data from three cohort studies to emulate trials examining the effects of starting antihypertensive medication on the incidence of dementia, while checking for potential biases in the methods used.
- * Results revealed inconsistent and imprecise links between antihypertensive medication initiation and dementia risk, raising concerns about residual confounding, which makes it difficult to draw solid conclusions about the relationship between these medications and dementia onset.
Article Synopsis
- The study investigated trends in liver cancer incidence in Hong Kong, Sweden, and the United States from the 1970s to 2021, using statistical methods to analyze data.
- Hong Kong experienced a steady decrease in liver cancer rates, while Sweden and the U.S. saw increases, with the U.S. showing a recent decline since 2015 primarily in hepatocellular carcinoma cases.
- The differences in trends across these regions might stem from varying causes and the effectiveness of preventive measures implemented in each population.
A Brief Model Evaluated Outcomes After Liver Transplantation Based on the Matching of Donor Graft and Recipient.
Clin Transl Gastroenterol
January 2025
Article Synopsis
- Scientists wanted a better way to predict how well liver transplants work, so they created a new model that uses information from both donors and recipients.
- They tested this model with data from 528 patients and found that specific factors, like cold ischemia time (how long the liver was without blood) and a score called MELD, could help predict survival after the transplant.
- The new model, called the CIT-MELD Index (CMI), was found to be more effective than older methods at predicting outcomes and understanding the risks involved in liver transplants.
Background: Colchicine has been approved to reduce cardiovascular risk in patients with coronary heart disease on the basis of its potential benefits demonstrated in the COLCOT (Colchicine Cardiovascular Outcomes Trial) and LoDoCo2 (Low-Dose Colchicine 2) studies. Nevertheless, there are limited data available about the specific impact of colchicine on coronary plaques.
Methods: This was a prospective, single-center, randomized, double-blind clinical trial.
Article Synopsis
- Primary familial brain calcification (PFBC) is a genetic neurological disorder with no current effective treatment, linked to mutations in the SLC20A2 gene.
- Researchers identified five new genetic variants in the SLC20A2 gene that disrupt normal splicing of its pre-mRNA, leading to dysfunctional protein production.
- The use of splice-switching antisense oligonucleotides (ASOs) not only helped restore functional SLC20A2 expression in affected cells but also showed promise in reducing brain calcification and controlling phosphorus levels in animal models, highlighting a potential therapeutic approach for PFBC.
Article Synopsis
- * Pulmonary long COVID was observed in 8.7% and 17.8% of patients at 1- and 2-year visits, while renal long COVID affected 15.2% and 23.9% of patients, respectively.
- * A machine learning model accurately predicted these long COVID outcomes using initial clinical and multi-omics data, and proteomics identified specific biomarkers linked to lung and kidney issues.